2. Gene
  3. DOK6 - docking protein 6 Gene

DOK6 - docking protein 6 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as DOK5L; HsT3226

Gene ID: 220164 | Gene type: protein coding

About DOK6

Cytogenetic location: 18q22.2 Genomic coordinates (GRCh38): 18:69,400,888-69,849,087 (from NCBI)

This gene has 5 transcripts (splice variants), 207 orthologues and 7 paralogues. Biased expression in brain (RPKM 6.3), kidney (RPKM 1.5) and 10 other tissues.

Summary

DOK6 is a member of the DOK (see DOK1; MIM 602919) family of intracellular adaptors that play a role in the RET (MIM 164761) signaling cascade (Crowder et al., 2004 [PubMed 15286081]).[supplied by OMIM, Mar 2008]

DOK6 Products(1)

mRNA Protein Name
NM_152721.6 NP_689934.2 docking protein 6
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16273093 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DOK6 Protein Structure

PH

PH: PH domain (8 - 109)

IRS

IRS: PTB domain (IRS-1 type) (136 - 230)

  • 0
  • 100
  • 200
  • 300
  • 331 a.a.
Protein Preferred Names Protein Names

docking protein 6

downstream of tyrosine kinase 6

DOK6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra DOK6 Q6PKX4 TBX15 Homo sapiens Q96SF7
Validated Y2H
32296183
Intra DOK6 Q6PKX4 TBX15 Homo sapiens Q96SF7
Y2H Array
32296183
Intra DOK6 Q6PKX4 TBX15 Homo sapiens Q96SF7
Y2H Prey Pooling
32296183
Intra DOK6 Q6PKX4 LGALS14 Homo sapiens Q8TCE9
Validated Y2H
32296183
Intra DOK6 Q6PKX4 TLE5 Homo sapiens Q08117-2
Y2H Prey Pooling
32296183
Intra DOK6 Q6PKX4 TLE5 Homo sapiens Q08117-2
Y2H Array
32296183
Intra DOK6 Q6PKX4 USP54 Homo sapiens Q70EL1-9
Validated Y2H
32296183
Intra DOK6 Q6PKX4 USP54 Homo sapiens Q70EL1-9
Y2H Array
32296183
Intra DOK6 Q6PKX4 USP54 Homo sapiens Q70EL1-9
Y2H Prey Pooling
32296183
Intra DOK6 Q6PKX4 ABHD11 Homo sapiens Q8NFV4-4
Y2H Prey Pooling
32296183
Intra DOK6 Q6PKX4 ABHD11 Homo sapiens Q8NFV4-4
Y2H Array
32296183
Intra DOK6 Q6PKX4 ABHD11 Homo sapiens Q8NFV4-4
Validated Y2H
32296183
Intra DOK6 Q6PKX4 FAM86C1P Homo sapiens Q9NVL1-2
Validated Y2H
32296183
Intra DOK6 Q6PKX4 FAM86C1P Homo sapiens Q9NVL1-2
Y2H Array
32296183
Intra DOK6 Q6PKX4 FAM86C1P Homo sapiens Q9NVL1-2
Y2H Prey Pooling
32296183
Intra DOK6 Q6PKX4 SLC30A6 Homo sapiens Q6NXT4-4
Y2H Array
32296183
Intra DOK6 Q6PKX4 SLC30A6 Homo sapiens Q6NXT4-4
Y2H Prey Pooling
32296183
Intra DOK6 Q6PKX4 CRYBB3 Homo sapiens P26998
Y2H Prey Pooling
32296183
Intra DOK6 Q6PKX4 CRYBB3 Homo sapiens P26998
Y2H Array
32296183
Intra DOK6 Q6PKX4 NTRK3 Homo sapiens Q16288
Y2H
20565848
Intra DOK6 Q6PKX4 NTRK3 Homo sapiens Q16288
Anti Tag CoIP
20565848
Intra DOK6 Q6PKX4 NTRK3 Homo sapiens Q16288
Pull Down
20565848
Intra DOK6 Q6PKX4 RUSC1 Homo sapiens Q9BVN2
Y2H Prey Pooling
32296183
Intra DOK6 Q6PKX4 RUSC1 Homo sapiens Q9BVN2
Y2H Array
32296183
Intra DOK6 Q6PKX4 RUSC1 Homo sapiens Q9BVN2
Validated Y2H
32296183
Intra DOK6 Q6PKX4 RBPMS Homo sapiens Q93062
Y2H Array
25416956
Intra DOK6 Q6PKX4 METTL27 Homo sapiens Q8N6F8
Y2H Prey Pooling
32296183
Intra DOK6 Q6PKX4 METTL27 Homo sapiens Q8N6F8
Validated Y2H
32296183
Intra DOK6 Q6PKX4 METTL27 Homo sapiens Q8N6F8
Y2H Array
32296183
Intra DOK6 Q6PKX4 LASP1 Homo sapiens Q14847-2
Y2H Prey Pooling
32296183
Intra DOK6 Q6PKX4 LASP1 Homo sapiens Q14847-2
Y2H Array
32296183
Intra DOK6 Q6PKX4 C1orf94 Homo sapiens Q6P1W5
Validated Y2H
25416956
Intra DOK6 Q6PKX4 C1orf94 Homo sapiens Q6P1W5
Y2H Array
25416956
Intra DOK6 Q6PKX4 ARID5A Homo sapiens Q03989
Y2H Prey Pooling
32296183
Intra DOK6 Q6PKX4 ARID5A Homo sapiens Q03989
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Malignant Iris Melanoma

Malignant Melanoma Of Iris

Melanoma Of The Iris
Hirschsprung Disease 1

Hirschsprung Disease

Aganglionic Megacolon

Hscr

Hirschsprung'S Disease

Congenital Megacolon

Congenital Intestinal Aganglionosis

Colonic Aganglionosis

Hirschsprung Disease, Susceptibility To, 1

Hirschsprung Disease, Protection Against

HSCR1

Mgc

Pelvirectal Achalasia

Total Intestinal Aganglionosis

Megacolon, Aganglionic

Macrocolon

Hscr 1

Hirschsprung Disease Type 1

Hirschsprung Disease, Type 1

Congenital Dilatation Of Colon

Aganglionosis

Congenital Aganglionic Megacolon

Aganglionosis Of Colon

Bowel Aganglionosis

Colon Aganglionosis

Hirschsprung Megacolon
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03938 DOK6 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus DOK6 VGNC VGNC:61585
Mus musculus DOK6 MGD MGI:3639495
Bos taurus DOK6 VGNC VGNC:28169
Macaca mulatta DOK6 VGNC VGNC:71915
Rattus norvegicus DOK6 RGD RGD:1564376
Canis familiaris DOK6 VGNC VGNC:40060