Tob1 - transducer of ErbB-2.1 Gene

Mus musculus

Also known as Tob; Trob

Gene ID: 22057 | Gene type: protein coding

About Tob1

Summary

Enables SMAD binding activity and transcription corepressor activity. Acts upstream of or within negative regulation of BMP signaling pathway; negative regulation of osteoblast differentiation; and regulation of SMAD protein signal transduction. Located in cytoplasm. Is expressed in 1st branchial arch; genitourinary system; limb; sensory organ; and skeleton. Orthologous to human TOB1 (transducer of ERBB2, 1). [provided by Alliance of Genome Resources, Apr 2022]

Tob1 Products(1)

mRNA	Protein	Name
NM_009427.2	NP_033453.2	protein Tob1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables SMAD binding	IDA IDA: Inferred from direct assay	11163184	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11163184	MGI
enables transcription corepressor activity	IDA IDA: Inferred from direct assay	11163184	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within negative regulation of BMP signaling pathway	IDA IDA: Inferred from direct assay	11163184	MGI
acts upstream of or within negative regulation of osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	11163184	MGI
acts upstream of or within regulation of SMAD protein signal transduction	IDA IDA: Inferred from direct assay	11163184	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11163184	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein Tob1

transducer of erbB2

Tob1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Tob1	Q61471	CORO7	Homo sapiens	P57737	Y2H	21130766
Cross	Tob1	Q61471	CORO7	Homo sapiens	P57737	IF	21130766

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14872	TOB1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tob1	NCBI	NCBI:10140

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