CORO7 - coronin 7 Gene

Homo sapiens

Also known as CRN7; POD1; 0610011B16Rik

Gene ID: 79585 | Gene type: protein coding

About CORO7

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:4,354,542-4,416,596 (from NCBI)

This gene has 33 transcripts (splice variants), 1 gene allele, 200 orthologues and 6 paralogues. Broad expression in bone marrow (RPKM 25.2), spleen (RPKM 18.8) and 24 other tissues.

Summary

This gene encodes a member of the coronin protein family. However, unlike other coronin proteins, it is not an actin-binding protein but rather functions as an F-actin regulator directing anterograde Golgi to endosome transport. The encoded protein has two tandem WD-40 domain repeats and localizes to the trans-Golgi network. The protein undergoes K33-linked polyubiquitination via an E3 Ligase complex. It is thought to play an essential role in maintenance of Golgi apparatus morphology. Alternative splicing results in multiple transcripts variants; some of which form read-through transcripts with a neighboring gene. [provided by RefSeq, Dec 2016]

CORO7 Products(4)

mRNA	Protein	Name
NM_001201472.2	NP_001188401.1	coronin-7 isoform 2
NM_001201473.2	NP_001188402.1	coronin-7 isoform 3
NM_001351729.2	NP_001338658.1	coronin-7 isoform 4
NM_024535.5	NP_078811.3	coronin-7 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables actin binding	IDA IDA: Inferred from direct assay	24768539	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21130766	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in Golgi to endosome transport	IMP IMP: Inferred from mutant phenotype	24768539	GOA
involved in actin filament polymerization	IMP IMP: Inferred from mutant phenotype	24768539	GOA
involved in positive regulation of hippo signaling	IMP IMP: Inferred from mutant phenotype	33162394	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in trans-Golgi network	IDA IDA: Inferred from direct assay	24768539	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CORO7 Protein Structure

WD40

Trimer_CC

WD40

Trimer_CC

0
200
400
600
800
925 a.a.

Protein Preferred Names

Protein Names

coronin-7

70 kDa WD repeat tumor rejection antigen homolog

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03053	CORO7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CORO7	RGD	RGD:621591
Mus musculus	CORO7	MGD	MGI:1926135

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