Trim24 - tripartite motif-containing 24 Gene

Mus musculus

Also known as TIF1; Tif1a; TIF1alpha; TIF1-alpha; A130082H20Rik; D430004I05Rik

Gene ID: 21848 | Gene type: protein coding

About Trim24

Summary

The protein encoded by this gene is part of the tripartite-motif containing family (TRIM), which are typified by the RING, B-box type 1, B-box type 2, and coiled-coil region domains. This protein, which also contains a PHD/TTC finger and bromodomain important for regulating nuclear receptors and binding chromatin, has important roles in differentiation, development, and tissue homeostasis. This protein has been reported to regulate the activity of the tumor suppressor p53 and of the retinoic acid receptor. A translocation event between this gene and BRaf transforming gene, which results in the fusion protein T18, has been reported in hepatocellular carcinomas. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]

Trim24 Products(3)

mRNA	Protein	Name
NM_001272064.1	NP_001258993.1	transcription intermediary factor 1-alpha isoform 2
NM_001272076.1	NP_001259005.1	transcription intermediary factor 1-alpha isoform 3
NM_145076.4	NP_659542.3	transcription intermediary factor 1-alpha isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables chromatin binding	IDA IDA: Inferred from direct assay	10318760	MGI
enables nuclear receptor binding	IDA IDA: Inferred from direct assay	15322135	MGI
enables p53 binding	IPI IPI: Inferred from physical interaction	19556538	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	8978696	MGI
enables protein kinase activity	IDA IDA: Inferred from direct assay	10562550	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	18026104	MGI
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	19909775	MGI
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	19556538	MGI
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	19556538	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within calcium ion homeostasis	IMP IMP: Inferred from mutant phenotype	18287084	MGI
acts upstream of epithelial cell proliferation	IGI IGI: Inferred from genetic interaction	18026104	MGI
acts upstream of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	18026104	MGI
acts upstream of or within negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	10562550	MGI
acts upstream of or within negative regulation of epithelial cell proliferation	IGI IGI: Inferred from genetic interaction	18026104	MGI
acts upstream of or within negative regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	18026104	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IGI IGI: Inferred from genetic interaction	7744009	MGI
acts upstream of or within positive regulation of gene expression	IGI IGI: Inferred from genetic interaction	18026104	MGI
acts upstream of or within positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	18026104	MGI
acts upstream of or within protein autophosphorylation	IDA IDA: Inferred from direct assay	10562550	MGI
involved in protein catabolic process	IMP IMP: Inferred from mutant phenotype	19556538	MGI
acts upstream of or within protein phosphorylation	IDA IDA: Inferred from direct assay	10562550	MGI
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	19556538	MGI
involved in regulation of protein stability	IMP IMP: Inferred from mutant phenotype	19556538	MGI
acts upstream of or within regulation of signal transduction by p53 class mediator	IGI IGI: Inferred from genetic interaction	19556538	MGI
acts upstream of or within regulation of vitamin D receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	18287084	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11331580	MGI
located in euchromatin	IDA IDA: Inferred from direct assay	10318760	MGI
located in male germ cell nucleus	IDA IDA: Inferred from direct assay	10525195	MGI
NOT located in nucleolus	IDA IDA: Inferred from direct assay	10318760	MGI
located in nucleus	IDA IDA: Inferred from direct assay	10318760	MGI
located in perichromatin fibrils	IDA IDA: Inferred from direct assay	10318760	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

transcription intermediary factor 1-alpha

E3 ubiquitin-protein ligase Trim24	RING-type E3 ubiquitin transferase TIF1-alpha
transcriptional intermediary factor 1, alpha	tripartite motif-containing protein 24

Trim24 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Trim24	Q64127	Trim33	Mus musculus	Q99PP7	Anti Bait CoIP	21531907
Intra	Trim24	Q64127	Cbx5	Mus musculus	Q61686	Pull Down	8978696
Intra	Trim24	Q64127	Tp53	Mus musculus	P02340	Anti Bait CoIP	19556538
Intra	Trim24	Q64127	Cbx1	Mus musculus	P83917	Pull Down	8978696
Intra	Trim24	Q64127	Cbx1	Mus musculus	P83917	Y2H	8978696

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-111519	dTRIM24	Inhibitor	99.92%	Unkown
HY-102000B	IACS-9571 hydrochloride	Inhibitor	99.85%	Unkown
HY-12518	OF-1	Inhibitor	98.93%	Unkown
HY-102000	IACS-9571	Inhibitor	/	Unkown
HY-RS15029	TRIM24 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-102000A	IACS-9571 TFA	Inhibitor	/	Unkown
HY-143332	TRIM24/BRPF1-IN-2	Inhibitor	/	Unkown
HY-161393	RB-CO-PEG5-C2-CO-VH032		/	Unkown
HY-122626	BRPF1B/TRIM24-IN-1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Trim24	NCBI	NCBI:8805

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