2. Gene
  3. Pin1 - peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1 Gene

Pin1 - peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as D9Bwg1161e; 0610025L01Rik

Gene ID: 23988 | Gene type: protein coding

About Pin1

Summary

Enables several functions, including beta-catenin binding activity; peptidyl-prolyl cis-trans isomerase activity; and phosphoprotein binding activity. Involved in several processes, including negative regulation of amyloid-beta formation; protein peptidyl-prolyl isomerization; and protein stabilization. Acts upstream of or within regulation of cell population proliferation and regulation of cytokinesis. Located in cytosol and nucleus. Is expressed in several structures, including 2-cell stage embryo; gut; nucleus pulposus; and reproductive system. Used to study Alzheimer's disease. Orthologous to human PIN1 (peptidylprolyl cis/trans isomerase, NIMA-interacting 1). [provided by Alliance of Genome Resources, Apr 2022]

Pin1 Products(2)

mRNA Protein Name
NM_001364495.1 NP_001351424.1 peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 isoform 2
NM_023371.4 NP_075860.1 peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables beta-catenin binding IPI
IPI: Inferred from physical interaction
22645310 MGI
enables cytoskeletal motor activity IMP
IMP: Inferred from mutant phenotype
22645310 MGI
enables peptidyl-prolyl cis-trans isomerase activity IDA
IDA: Inferred from direct assay
16554819 MGI
enables phosphoprotein binding IPI
IPI: Inferred from physical interaction
23362255 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17347650 MGI
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of amyloid-beta formation IMP
IMP: Inferred from mutant phenotype
16554819 MGI
involved in neuron differentiation IMP
IMP: Inferred from mutant phenotype
22645310 MGI
involved in protein peptidyl-prolyl isomerization IDA
IDA: Inferred from direct assay
16554819 MGI
involved in protein stabilization IMP
IMP: Inferred from mutant phenotype
11533658 MGI
acts upstream of or within regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
12810604 MGI
acts upstream of or within regulation of cytokinesis IMP
IMP: Inferred from mutant phenotype
19638580 MGI
involved in regulation protein catabolic process at postsynapse EXP
EXP: Inferred from Experiment
28458925 MGI
involved in regulation protein catabolic process at postsynapse IDA
IDA: Inferred from direct assay
28458925 MGI
involved in regulation protein catabolic process at postsynapse IEP
IEP: Inferred from expression pattern
28458925 MGI
involved in regulation protein catabolic process at postsynapse IMP
IMP: Inferred from mutant phenotype
28458925 MGI
involved in synapse organization IMP
IMP: Inferred from mutant phenotype
22645310 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cytosol IDA
IDA: Inferred from direct assay
22645310 MGI
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
28458925 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
28458925 MGI
is active in glutamatergic synapse IEP
IEP: Inferred from expression pattern
28458925 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
28458925 MGI
located in nucleus IDA
IDA: Inferred from direct assay
22645310 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

PPIase Pin1

peptidyl-prolyl cis-trans isomerase Pin1

protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1

rotamase Pin1

Pin1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
Pin1 Q9QUR7 Tp53 Mus musculus P02340
Anti Bait CoIP
21741598
Intra
Pin1 Q9QUR7 Gphn Mus musculus Q8BUV3
Pull Down
17347650
Intra
Pin1 Q9QUR7 Gphn Mus musculus Q8BUV3
IF
17347650
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (14)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-139361 Sulfopin Inhibitor 99.69% Unkown
HY-123847 KPT-6566 Inhibitor ≥98.0% Unkown
HY-128034 PPIase-Parvulin inhibitor Inhibitor 99.79% Unkown
HY-153675 BCPA Modulator 98.51% Unkown
HY-P4359 Suc-AEPF-AMC Inhibitor 98.67% Unkown
HY-128592 TAB29 Inhibitor / Unkown
HY-143903 ZL-Pin13 Inhibitor / Unkown
HY-164895 PIN1 degrader-1 Degrader / Unkown
HY-137122 3-Pyridine toxoflavin Inhibitor / Unkown
HY-143902 ZL-Pin01 Inhibitor / Unkown
HY-168037 PROTAC PIN1 degrader-1 / Unkown
HY-168036 PIN1 inhibitor 3 Inhibitor / Unkown
HY-170429 BJP-07-017-3 Inhibitor / Unkown
HY-12135 Poloxipan Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pin1 NCBI NCBI:5300