Trp63 - transformation related protein 63 Gene

Mus musculus

Also known as Ket; P63; P73l; Tp63; P51/P63; Trp53rp1

Gene ID: 22061 | Gene type: protein coding

About Trp63

Summary

This gene encodes tumor protein p63, a member of the p53 family of transcription factors involved in cellular responses to stress and development. The family members include tumor proteins p53, p63, and p73, which have high sequence similarity to one another. This similarity allows p63 and p73 to transactivate p53-responsive genes causing cell cycle arrest and Apoptosis. The family members can interact with each Other in many ways, including direct and indirect protein interactions. This results in mutual regulation of target gene promoters. Tumor protein p63 -/- mice have several developmental defects which include the lack of limbs and Other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Both alternative splicing and the use of alternative promoters result in multiple transcript variants encoding different protein isoforms.[provided by RefSeq, Dec 2009]

Trp63 Products(16)

mRNA	Protein	Name
NM_001127259.1	NP_001120731.1	tumor protein 63 isoform a
NM_001127260.1	NP_001120732.1	tumor protein 63 isoform b
NM_001127261.1	NP_001120733.1	tumor protein 63 isoform c
NM_001127262.1	NP_001120734.1	tumor protein 63 isoform f
NM_001127263.1	NP_001120735.1	tumor protein 63 isoform g
NM_001127264.1	NP_001120736.1	tumor protein 63 isoform e
NM_001127265.1	NP_001120737.1	tumor protein 63 isoform h
NM_011641.2	NP_035771.1	tumor protein 63 isoform d
NM_001127259.1	NP_001120731.1	tumor protein 63 isoform a
NM_001127260.1	NP_001120732.1	tumor protein 63 isoform b
NM_001127261.1	NP_001120733.1	tumor protein 63 isoform c
NM_001127262.1	NP_001120734.1	tumor protein 63 isoform f
NM_001127263.1	NP_001120735.1	tumor protein 63 isoform g
NM_001127264.1	NP_001120736.1	tumor protein 63 isoform e
NM_001127265.1	NP_001120737.1	tumor protein 63 isoform h
NM_011641.2	NP_035771.1	tumor protein 63 isoform d

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	16363065	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	21930775	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	16524929	MGI
enables damaged DNA binding	IDA IDA: Inferred from direct assay	17122775	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	21335238	MGI
enables promoter-specific chromatin binding	IDA IDA: Inferred from direct assay	37115925	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	19345189	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	18256694	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of Notch signaling pathway	IMP IMP: Inferred from mutant phenotype	22274697	MGI
acts upstream of or within anatomical structure formation involved in morphogenesis	IMP IMP: Inferred from mutant phenotype	17878916	MGI
acts upstream of or within animal organ morphogenesis	IMP IMP: Inferred from mutant phenotype	10227294	MGI
acts upstream of or within cellular senescence	IMP IMP: Inferred from mutant phenotype	16107615	MGI
acts upstream of or within chromatin remodeling	IMP IMP: Inferred from mutant phenotype	21930775	MGI
acts upstream of or within cloacal septation	IMP IMP: Inferred from mutant phenotype	12368184	MGI
acts upstream of or within cranial skeletal system development	IMP IMP: Inferred from mutant phenotype	25503409	MGI
acts upstream of or within determination of adult lifespan	IMP IMP: Inferred from mutant phenotype	16107615	MGI
acts upstream of or within ectoderm and mesoderm interaction	IMP IMP: Inferred from mutant phenotype	10227293	MGI
acts upstream of or within embryonic forelimb morphogenesis	IMP IMP: Inferred from mutant phenotype	25503409	MGI
acts upstream of or within embryonic hindlimb morphogenesis	IMP IMP: Inferred from mutant phenotype	25503409	MGI
acts upstream of or within embryonic limb morphogenesis	IGI IGI: Inferred from genetic interaction	18326838	MGI
acts upstream of or within embryonic limb morphogenesis	IMP IMP: Inferred from mutant phenotype	10227293	MGI
acts upstream of or within epidermal cell differentiation	IMP IMP: Inferred from mutant phenotype	25503409	MGI
acts upstream of or within epidermal cell division	IMP IMP: Inferred from mutant phenotype	21127502	MGI
acts upstream of or within epidermis development	IMP IMP: Inferred from mutant phenotype	10227293	MGI
acts upstream of or within epithelial cell development	IMP IMP: Inferred from mutant phenotype	21127502	MGI
acts upstream of or within epithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	12368184	MGI
acts upstream of or within establishment of planar polarity	IDA IDA: Inferred from direct assay	14729569	MGI
involved in establishment of skin barrier	IMP IMP: Inferred from mutant phenotype	24075906	MGI
acts upstream of or within female genitalia morphogenesis	IMP IMP: Inferred from mutant phenotype	12368184	MGI
acts upstream of or within hair follicle development	IMP IMP: Inferred from mutant phenotype	16410075	MGI
acts upstream of or within hair follicle morphogenesis	IMP IMP: Inferred from mutant phenotype	16524929	MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IMP IMP: Inferred from mutant phenotype	17122775	MGI
acts upstream of or within keratinocyte differentiation	IDA IDA: Inferred from direct assay	14729569	MGI
acts upstream of keratinocyte proliferation	IGI IGI: Inferred from genetic interaction	24075906	MGI
acts upstream of or within morphogenesis of a polarized epithelium	IMP IMP: Inferred from mutant phenotype	15189821	MGI
involved in negative regulation of intracellular estrogen receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	25655704	MGI
acts upstream of or within negative regulation of keratinocyte differentiation	IMP IMP: Inferred from mutant phenotype	22274697	MGI
acts upstream of or within negative regulation of mesoderm development	IMP IMP: Inferred from mutant phenotype	21127502	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	23906066	MGI
acts upstream of or within neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	16337913	MGI
acts upstream of or within odontogenesis of dentin-containing tooth	IMP IMP: Inferred from mutant phenotype	16410075	MGI
acts upstream of or within pattern specification process	IMP IMP: Inferred from mutant phenotype	10227294	MGI
acts upstream of or within polarized epithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	15189821	MGI
acts upstream of or within positive regulation of Notch signaling pathway	IMP IMP: Inferred from mutant phenotype	22274697	MGI
acts upstream of or within positive regulation of apoptotic signaling pathway	IDA IDA: Inferred from direct assay	9774969	MGI
acts upstream of or within positive regulation of keratinocyte proliferation	IGI IGI: Inferred from genetic interaction	24075906	MGI
involved in positive regulation of somatic stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	25655704	MGI
acts upstream of or within positive regulation of stem cell proliferation	IGI IGI: Inferred from genetic interaction	24075906	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9774969	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	15982302	MGI
acts upstream of or within post-anal tail morphogenesis	IMP IMP: Inferred from mutant phenotype	12368184	MGI
acts upstream of or within prostate gland development	IMP IMP: Inferred from mutant phenotype	11106548	MGI
acts upstream of or within prostatic bud formation	IMP IMP: Inferred from mutant phenotype	11106548	MGI
acts upstream of or within proximal/distal pattern formation	IMP IMP: Inferred from mutant phenotype	10227293	MGI
acts upstream of or within regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	18159078	MGI
involved in regulation of epidermal cell division	IMP IMP: Inferred from mutant phenotype	24075906	MGI
acts upstream of or within skeletal system development	IMP IMP: Inferred from mutant phenotype	10227294	MGI
acts upstream of or within skin epidermis development	IMP IMP: Inferred from mutant phenotype	25503409	MGI
acts upstream of or within skin morphogenesis	IMP IMP: Inferred from mutant phenotype	17041603	MGI
acts upstream of or within squamous basal epithelial stem cell differentiation involved in prostate gland acinus development	IMP IMP: Inferred from mutant phenotype	15371309	MGI
acts upstream of or within stem cell differentiation	IMP IMP: Inferred from mutant phenotype	15371309	MGI
acts upstream of stem cell proliferation	IGI IGI: Inferred from genetic interaction	24075906	MGI
acts upstream of or within stem cell proliferation	IMP IMP: Inferred from mutant phenotype	25503409	MGI
acts upstream of or within sympathetic nervous system development	IMP IMP: Inferred from mutant phenotype	16337913	MGI
acts upstream of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	23906066	MGI
acts upstream of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	15982302	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	11106548	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

tumor protein 63

Trp63 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Tp63	O88898	Tp63	Mus musculus	O88898	GMS	21335238
Intra	Tp63	O88898	Cables1	Mus musculus	Q9ESJ1	Anti Bait CoIP	20559324
Intra	Tp63	O88898	Tp73	Mus musculus	Q9JJP2	Y2H Array	20211142
Intra	Tp63	O88898	SUMO1	Homo sapiens	P63165	Anti Tag CoIP	22370726

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P0028	Phalloidin		99.83%	Unkown
HY-P1640	(Trp63,Trp64)-C3a(63-77)	Agonist	/	Unkown

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