SKA3 - spindle and kinetochore associated complex subunit 3 Gene

Homo sapiens

Also known as RAMA1; C13orf3

Gene ID: 221150 | Gene type: protein coding

About SKA3

Cytogenetic location: 13q12.11 Genomic coordinates (GRCh38): 13:21,153,595-21,176,552 (from NCBI)

This gene has 7 transcripts (splice variants) and 195 orthologues. Biased expression in testis (RPKM 4.8), bone marrow (RPKM 3.0) and 13 other tissues.

Summary

This gene encodes a component of the spindle and kinetochore-associated protein complex that regulates microtubule attachment to the kinetochores during mitosis. The encoded protein localizes to the outer kinetechore and may be required for normal chromosome segregation and cell division. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

SKA3 Products(2)

mRNA	Protein	Name
NM_001166017.2	NP_001159489.1	spindle and kinetochore-associated protein 3 isoform 2
NM_145061.6	NP_659498.4	spindle and kinetochore-associated protein 3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables microtubule binding	IDA IDA: Inferred from direct assay	29487209	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19289083	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in attachment of mitotic spindle microtubules to kinetochore	IDA IDA: Inferred from direct assay	29487209	GOA
involved in attachment of mitotic spindle microtubules to kinetochore	IMP IMP: Inferred from mutant phenotype	28479321	GOA
involved in metaphase chromosome alignment	IMP IMP: Inferred from mutant phenotype	22371557	GOA
involved in mitotic metaphase chromosome alignment	IPI IPI: Inferred from physical interaction	28495837	GOA
involved in mitotic sister chromatid segregation	IMP IMP: Inferred from mutant phenotype	19289083	GOA
involved in negative regulation of mitotic spindle assembly checkpoint signaling	IMP IMP: Inferred from mutant phenotype	19646878	GOA
involved in regulation of microtubule polymerization or depolymerization	IDA IDA: Inferred from direct assay	19289083	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of SKA complex	IDA IDA: Inferred from direct assay	31804178	GOA
located in centrosome	IDA IDA: Inferred from direct assay	19646878	GOA
located in kinetochore	IDA IDA: Inferred from direct assay	20813266	GOA
located in kinetochore	IPI IPI: Inferred from physical interaction	21633384	GOA
located in mitotic spindle	IDA IDA: Inferred from direct assay	19646878	GOA
part of outer kinetochore	IDA IDA: Inferred from direct assay	19289083	GOA
located in spindle microtubule	IDA IDA: Inferred from direct assay	19289083	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

spindle and kinetochore-associated protein 3

SKA3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SKA3	Q8IX90	SKA1	Homo sapiens	Q96BD8	Anti Tag CoIP	33961781
Intra	SKA3	Q8IX90	SKA1	Homo sapiens	Q96BD8	Anti Tag CoIP	28514442
Intra	SKA3	Q8IX90	SKA1	Homo sapiens	Q96BD8	Validated Y2H	32296183
Intra	SKA3	Q8IX90	SKA1	Homo sapiens	Q96BD8	Anti Tag CoIP	26496610
Intra	SKA3	Q8IX90	SKA1	Homo sapiens	Q96BD8	IF	19360002
Intra	SKA3	Q8IX90	SKA1	Homo sapiens	Q96BD8	Anti Tag CoIP	19360002

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Uterine Adnexa Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12966	SKA3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SKA3	VGNC	VGNC:65168
Rattus norvegicus	SKA3	RGD	RGD:1307201
Canis familiaris	SKA3	VGNC	VGNC:46195
Bos taurus	SKA3	VGNC	VGNC:34645
Macaca mulatta	SKA3	VGNC	VGNC:77525
Mus musculus	SKA3	MGD	MGI:3041235

Name
Email *

	Sorry, but the email address you supplied was invalid.