SKA1 - spindle and kinetochore associated complex subunit 1 Gene

Homo sapiens

Also known as C18orf24

Gene ID: 220134 | Gene type: protein coding

About SKA1

Cytogenetic location: 18q21.1 Genomic coordinates (GRCh38): 18:50,375,046-50,394,168 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele and 97 orthologues. Biased expression in bone marrow (RPKM 4.0), testis (RPKM 3.1) and 12 other tissues.

Summary

Enables microtubule binding activity. Involved in several processes, including chromosome segregation; mitotic cell cycle; and regulation of microtubule polymerization or depolymerization. Located in spindle microtubule. Part of outer kinetochore. [provided by Alliance of Genome Resources, Apr 2022]

SKA1 Products(2)

mRNA	Protein	Name
NM_001039535.3	NP_001034624.1	spindle and kinetochore-associated protein 1
NM_145060.4	NP_659497.1	spindle and kinetochore-associated protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables microtubule binding	IDA IDA: Inferred from direct assay	19289083	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in attachment of mitotic spindle microtubules to kinetochore	IDA IDA: Inferred from direct assay	29487209	GOA
involved in attachment of mitotic spindle microtubules to kinetochore	IMP IMP: Inferred from mutant phenotype	36592928	GOA
involved in metaphase chromosome alignment	IMP IMP: Inferred from mutant phenotype	22371557	GOA
involved in mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	19289083	GOA
involved in mitotic metaphase chromosome alignment	IMP IMP: Inferred from mutant phenotype	28495837	GOA
involved in mitotic sister chromatid segregation	IMP IMP: Inferred from mutant phenotype	17093495	GOA
involved in negative regulation of mitotic spindle assembly checkpoint signaling	IMP IMP: Inferred from mutant phenotype	26981768	GOA
involved in positive regulation of microtubule polymerization	IDA IDA: Inferred from direct assay	27225956	GOA
involved in regulation of microtubule polymerization or depolymerization	IDA IDA: Inferred from direct assay	19289083	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of SKA complex	IDA IDA: Inferred from direct assay	31804178	GOA
located in centrosome	IDA IDA: Inferred from direct assay	26981768	GOA
located in kinetochore	IDA IDA: Inferred from direct assay	24413531	GOA
located in kinetochore	IPI IPI: Inferred from physical interaction	21633384	GOA
located in mitotic spindle	IDA IDA: Inferred from direct assay	26981768	GOA
located in mitotic spindle microtubule	IDA IDA: Inferred from direct assay	27225956	GOA
part of outer kinetochore	IDA IDA: Inferred from direct assay	17093495	GOA
located in spindle microtubule	IDA IDA: Inferred from direct assay	17093495	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SKA1 Protein Structure

SKA1

0
100
200
255 a.a.

Protein Preferred Names

Protein Names

spindle and kinetochore-associated protein 1

spindle and KT (kinetochore) associated 1

Related Diseases

Diseases

Alias

Serous Labyrinthitis

Acute Serous Labyrinthitis

Ovary Serous Adenocarcinoma

Malignant Ovarian Serous Tumor

Serous Carcinoma Of Ovary

Acute Poststreptococcal Glomerulonephritis

Post-Streptococcal Glomerulonephritis

Acute Post-Streptococcal Glomerulonephritis

Filippi Syndrome

Scott Craniodigital Syndrome With Mental Retardation	Type 1 Syndactyly-Microcephaly-Intellectual Disability Syndrome
FLPIS	Scott Bryant Graham Syndrome
Craniodigital-Intellectual Disability Syndrome	Scott Craniodigital Syndrome
Scott-Bryant-Graham Syndrome	Syndactyly, Type I, With Microcephaly And Mental Retardation
Syndactyly Type I With Microcephaly And Intellectual Disability	Unusual Facial Appearance, Microcephaly, Growth And Intellectual Disability And Syndactyly
Craniodigital Syndrome With Intellectual Disability	Craniodigital Syndrome-Intellectual Disability Syndrome
Craniodigital Syndrome-Intellectual Disability, Scott Type	Intellectual Disability-Craniodigital Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12964	SKA1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SKA1	RGD	RGD:1310784
Bos taurus	SKA1	VGNC	VGNC:34643
Canis familiaris	SKA1	VGNC	VGNC:46193
Felis catus	SKA1	VGNC	VGNC:65167
Mus musculus	SKA1	MGD	MGI:1913718
Macaca mulatta	SKA1	VGNC	VGNC:77577

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