SPATA13 - spermatogenesis associated 13 Gene

Homo sapiens

Also known as ASEF2; ARHGEF29

Gene ID: 221178 | Gene type: protein coding

About SPATA13

Cytogenetic location: 13q12.12 Genomic coordinates (GRCh38): 13:23,979,802-24,307,069 (from NCBI)

This gene has 12 transcripts (splice variants), 202 orthologues and 22 paralogues. Ubiquitous expression in spleen (RPKM 22.0), lymph node (RPKM 7.6) and 25 other tissues.

Summary

Enables guanyl-nucleotide exchange factor activity and identical protein binding activity. Involved in cell migration; plasma membrane bounded cell projection assembly; and regulation of cell migration. Located in several cellular components, including filopodium; lamellipodium; and ruffle membrane. [provided by Alliance of Genome Resources, Apr 2022]

SPATA13 Products(6)

mRNA	Protein	Name
NM_001166271.3	NP_001159743.1	spermatogenesis-associated protein 13 isoform 1
NM_001286792.2	NP_001273721.1	spermatogenesis-associated protein 13 isoform 3
NM_001286793.2	NP_001273722.1	spermatogenesis-associated protein 13 isoform 4
NM_001286794.2	NP_001273723.1	spermatogenesis-associated protein 13 isoform 5
NM_001286795.2	NP_001273724.1	spermatogenesis-associated protein 13 isoform 6
NM_153023.4	NP_694568.1	spermatogenesis-associated protein 13 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables guanyl-nucleotide exchange factor activity	IDA IDA: Inferred from direct assay	19934221	GOA
enables guanyl-nucleotide exchange factor activity	IMP IMP: Inferred from mutant phenotype	17145773	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	17145773	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17145773	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell migration	IMP IMP: Inferred from mutant phenotype	17145773	GOA
involved in filopodium assembly	IMP IMP: Inferred from mutant phenotype	17145773	GOA
involved in lamellipodium assembly	IMP IMP: Inferred from mutant phenotype	17599059	GOA
involved in regulation of cell migration	IMP IMP: Inferred from mutant phenotype	17599059	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	19151759	GOA
located in filopodium	IDA IDA: Inferred from direct assay	17599059	GOA
located in lamellipodium	IDA IDA: Inferred from direct assay	17599059	GOA
located in ruffle membrane	IDA IDA: Inferred from direct assay	19151759	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SPATA13 Protein Structure

SH3_9

RhoGEF

0
100
200
300
400
500
600
652 a.a.

Protein Preferred Names

Protein Names

spermatogenesis-associated protein 13

APC-stimulated guanine nucleotide exchange factor 2

Related Diseases

Diseases

Alias

Optic Atrophy 3, Autosomal Dominant

Optic Atrophy 3	OPA3
Autosomal Dominant Optic Atrophy And Cataract	Optic Atrophy And Cataract, Autosomal Dominant
Autosomal Dominant Optic Atrophy Type 3	Optic Atrophy 3 With Cataract
Opa3, Autosomal Dominant	Adoac
Optic Atrophy, Cataract, And Neurologic Disorder	Autosomal Dominant Optic Atrophy 3
Optic Atrophy Type 3	Optic Atrophy 3 Autosomal Dominant
Atrophy, Optic, Type 3, Autosomal Dominant	3-Methylglutaconic Aciduria Type 3

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13636	SPATA13 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SPATA13	MGD	MGI:104838
Rattus norvegicus	SPATA13	RGD	RGD:1307364

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