FGD2 - FYVE, RhoGEF and PH domain containing 2 Gene

Homo sapiens

Also known as ZFYVE4

Gene ID: 221472 | Gene type: protein coding

About FGD2

Cytogenetic location: 6p21.2 Genomic coordinates (GRCh38): 6:37,005,655-37,029,069 (from NCBI)

This gene has 11 transcripts (splice variants), 135 orthologues and 10 paralogues. Biased expression in spleen (RPKM 19.9), lymph node (RPKM 9.1) and 13 other tissues.

Summary

The protein encoded by this gene belongs to a family of guanine nucleotide exchange factors (GEFs) which control cytoskeleton-dependent membrane rearrangements by activating the cell division cycle 42 (CDC42) protein. This gene is expressed in B lymphocytes, macrophages, and dendritic cells. The encoded protein may play a role in leukocyte signaling and vesicle trafficking in antigen-presenting cells in the immune system. [provided by RefSeq, Oct 2016]

FGD2 Products(1)

mRNA	Protein	Name
NM_173558.4	NP_775829.2	FYVE, RhoGEF and PH domain-containing protein 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FGD2 Protein Structure

RhoGEF

FYVE

0
200
400
600
655 a.a.

Protein Preferred Names

Protein Names

FYVE, RhoGEF and PH domain-containing protein 2

FGD1 family, member 2

FGD2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	FGD2	Q7Z6J4	RPRM	Homo sapiens	Q9NS64	Validated Y2H	32296183
Intra	FGD2	Q7Z6J4	RPRM	Homo sapiens	Q9NS64	Y2H Array	32296183
Intra	FGD2	Q7Z6J4	RPRM	Homo sapiens	Q9NS64	Y2H Prey Pooling	32296183
Intra	FGD2	Q7Z6J4	KLHL12	Homo sapiens	Q53G59	Y2H Array	25416956
Intra	FGD2	Q7Z6J4	KLHL12	Homo sapiens	Q53G59	Y2H Prey Pooling	25416956
Intra	FGD2	Q7Z6J4	KLHL12	Homo sapiens	Q53G59	Validated Y2H	25416956
Intra	FGD2	Q7Z6J4	PLEKHG4	Homo sapiens	Q58EX7	Y2H Prey Pooling	32296183
Intra	FGD2	Q7Z6J4	PLEKHG4	Homo sapiens	Q58EX7	Y2H Array	32296183
Intra	FGD2	Q7Z6J4	TMEM239	Homo sapiens	Q8WW34	Y2H Prey Pooling	25416956
Intra	FGD2	Q7Z6J4	TMEM239	Homo sapiens	Q8WW34	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04881	FGD2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	FGD2	MGD	MGI:1347084
Bos taurus	FGD2	VGNC	VGNC:28965
Macaca mulatta	FGD2	VGNC	VGNC:72643
Felis catus	FGD2	VGNC	VGNC:62240
Canis familiaris	FGD2	VGNC	VGNC:40834
Rattus norvegicus	FGD2	RGD	RGD:1309840

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