2. Gene
  3. PLEKHG4 - pleckstrin homology and RhoGEF domain containing G4 Gene

PLEKHG4 - pleckstrin homology and RhoGEF domain containing G4 Gene

  • Gene
  • Protein
  • Agent
Homo sapiens (human)

Also known as SCA4; PRTPHN1; ARHGEF44

Gene ID: 25894 | Gene type: protein coding

About PLEKHG4

Summary

The protein encoded by this gene can function as a guanine nucleotide exchange factor (GEF) and may play a role in intracellular signaling and Cytoskeleton dynamics at the Golgi apparatus. Polymorphisms in the region of this gene have been found to be associated with spinocerebellar ataxia in some study populations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

PLEKHG4 Products(1)

mRNA Protein Name
NM_001129728.2 NP_001123200.1 puratrophin-1 isoform 1
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

puratrophin-1

PH domain-containing family G member 4

Purkinje cell atrophy associated protein 1

pleckstrin homology domain containing, family G (with RhoGef domain) member 4

PLEKHG4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra PLEKHG4 Q58EX7 MYEF2 Homo sapiens Q9P2K5-2
Validated Y2H
32296183
Intra PLEKHG4 Q58EX7 FGD2 Homo sapiens Q7Z6J4
Validated Y2H
32296183
Intra PLEKHG4 Q58EX7 MSRB3 Homo sapiens Q8IXL7-2
Validated Y2H
32296183
Intra PLEKHG4 Q58EX7 PKP2 Homo sapiens Q99959-2
Validated Y2H
32296183
Intra PLEKHG4 Q58EX7 ZNF148 Homo sapiens Q9UQR1-2
Validated Y2H
32296183
Intra PLEKHG4 Q58EX7 TFAP2D Homo sapiens Q7Z6R9
Validated Y2H
32296183
Intra PLEKHG4 Q58EX7 ZNF648 Homo sapiens Q5T619
Validated Y2H
32296183
Intra PLEKHG4 Q58EX7 ZNF319 Homo sapiens Q9P2F9
Validated Y2H
32296183
Intra PLEKHG4 Q58EX7 SAXO4 Homo sapiens Q7Z5V6-2
Validated Y2H
32296183
Intra PLEKHG4 Q58EX7 SHISA6 Homo sapiens Q6ZSJ9
Validated Y2H
32296183
Intra PLEKHG4 Q58EX7 DPPA3 Homo sapiens Q6W0C5
Validated Y2H
32296183
Intra PLEKHG4 Q58EX7 SETD5 Homo sapiens Q9C0A6-3
Validated Y2H
32296183
Intra PLEKHG4 Q58EX7 MGC50722 Homo sapiens Q8IVT4
Validated Y2H
32296183
Intra PLEKHG4 Q58EX7 PRPF31 Homo sapiens Q8WWY3
Validated Y2H
32296183
Intra PLEKHG4 Q58EX7 MALSU1 Homo sapiens Q96EH3
Validated Y2H
32296183
Intra PLEKHG4 Q58EX7 PRPF18 Homo sapiens Q99633
Validated Y2H
32296183
Intra PLEKHG4 Q58EX7 A1CF Homo sapiens Q9NQ94
Validated Y2H
32296183
Intra PLEKHG4 Q58EX7 SMG9 Homo sapiens Q9H0W8
Validated Y2H
32296183
Intra PLEKHG4 Q58EX7 TFG Homo sapiens Q92734
Validated Y2H
32296183
Intra PLEKHG4 Q58EX7 PSMB1 Homo sapiens P20618
Y2H Array
32296183
Intra PLEKHG4 Q58EX7 TSSK3 Homo sapiens Q96PN8
Validated Y2H
32296183
Intra PLEKHG4 Q58EX7 ZCCHC14 Homo sapiens Q8WYQ9
Validated Y2H
32296183
Intra PLEKHG4 Q58EX7 SAXO1 Homo sapiens Q8IYX7
Validated Y2H
32296183
Intra PLEKHG4 Q58EX7 FAM161A Homo sapiens Q3B820
Validated Y2H
32296183
Intra PLEKHG4 Q58EX7 MDFI Homo sapiens Q99750
Y2H Prey Pooling
25416956
Intra PLEKHG4 Q58EX7 MDFI Homo sapiens Q99750
Validated Y2H
25416956
Intra PLEKHG4 Q58EX7 DTX2 Homo sapiens Q86UW9
Validated Y2H
32296183
Intra PLEKHG4 Q58EX7 CHIC2 Homo sapiens Q9UKJ5
Validated Y2H
32296183
Intra PLEKHG4 Q58EX7 ARMC7 Homo sapiens Q9H6L4
Validated Y2H
32296183
Intra PLEKHG4 Q58EX7 MYOZ1 Homo sapiens Q9NP98
Validated Y2H
32296183
Intra PLEKHG4 Q58EX7 CCDC120 Homo sapiens Q96HB5
Validated Y2H
32296183
Intra PLEKHG4 Q58EX7 TENT5D Homo sapiens Q8NEK8
Validated Y2H
32296183
Intra PLEKHG4 Q58EX7 BEX2 Homo sapiens Q9BXY8
Validated Y2H
32296183
Intra PLEKHG4 Q58EX7 SH2D4A Homo sapiens Q9H788
Validated Y2H
32296183
Intra PLEKHG4 Q58EX7 DUSP13B Homo sapiens Q9UII6
Validated Y2H
32296183
Intra PLEKHG4 Q58EX7 TEKT3 Homo sapiens Q9BXF9
Validated Y2H
32296183
Intra PLEKHG4 Q58EX7 NATD1 Homo sapiens Q8N6N6
Validated Y2H
32296183
Intra PLEKHG4 Q58EX7 TBC1D22B Homo sapiens Q9NU19
Validated Y2H
32296183
Intra PLEKHG4 Q58EX7 TTC23 Homo sapiens Q5W5X9-3
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10692 PLEKHG4B Human Pre-designed siRNA Set A Pre-designed Sets / Unkown