FOXK1 - forkhead box K1 Gene

Homo sapiens

Also known as FOXK1L

Gene ID: 221937 | Gene type: protein coding

About FOXK1

Cytogenetic location: 7p22.1 Genomic coordinates (GRCh38): 7:4,682,295-4,771,442 (from NCBI)

This gene has 3 transcripts (splice variants), 196 orthologues and 42 paralogues. Ubiquitous expression in brain (RPKM 5.1), testis (RPKM 3.8) and 25 other tissues.

Summary

Enables 14-3-3 protein binding activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; and transcription cis-regulatory region binding activity. Involved in several processes, including cellular glucose homeostasis; negative regulation of autophagy; and regulation of transcription, DNA-templated. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

FOXK1 Products(1)

mRNA	Protein	Name
NM_001037165.2	NP_001032242.1	forkhead box protein K1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 14-3-3 protein binding	IPI IPI: Inferred from physical interaction	29861159	GOA
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	29861159	GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	17670796	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17670796	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	17670796	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of canonical glycolysis	IDA IDA: Inferred from direct assay	30700909	GOA
involved in intracellular glucose homeostasis	IDA IDA: Inferred from direct assay	29861159	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	17670796	GOA
involved in negative regulation of autophagy	IDA IDA: Inferred from direct assay	25402684	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	29861159	GOA
involved in regulation of glucose metabolic process	IDA IDA: Inferred from direct assay	29861159	GOA
involved in response to starvation	IDA IDA: Inferred from direct assay	25402684	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	25402684	GOA
located in nucleus	IDA IDA: Inferred from direct assay	25402684	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FOXK1 Protein Structure

FHA

Forkhead

0
200
400
600
733 a.a.

Protein Preferred Names

Protein Names

forkhead box protein K1

MNF

FOXK1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	FOXK1	P85037	FOXO3	Homo sapiens	O43524	Pull Down	25609649

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Bainbridge-Ropers Syndrome

BRPS	Severe Feeding Difficulties-Failure To Thrive-Microcephaly Due To Asxl3 Deficiency Syndrome
Asxl3-Related Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05059	FOXK1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	FOXK1	RGD	RGD:1309643
Canis familiaris	FOXK1	VGNC	VGNC:40957
Mus musculus	FOXK1	MGD	MGI:1347488
Bos taurus	FOXK1	VGNC	VGNC:58377
Macaca mulatta	FOXK1	VGNC	VGNC:72558

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