1. Gene
  2. FOXO3 - forkhead box O3 Gene

FOXO3 - forkhead box O3 Gene

Homo sapiens

Also known as FOXO2; AF6q21; FKHRL1; FOXO3A; FKHRL1P2

Gene ID: 2309 | Gene type: protein coding

About FOXO3

Cytogenetic location: 6q21 Genomic coordinates (GRCh38): 6:108,559,825-108,684,774 (from NCBI)

This gene has 3 transcripts (splice variants), 176 orthologues, 42 paralogues and is associated with 67 phenotypes. Ubiquitous expression in fat (RPKM 14.1), bone marrow (RPKM 13.9) and 25 other tissues.

Summary

This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for Apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]

FOXO3 Products(2)

mRNA Protein Name
NM_001455.4 NP_001446.1 forkhead box protein O3
NM_201559.3 NP_963853.1 forkhead box protein O3
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables DNA binding IDA
IDA: Inferred from direct assay
21329882 GOA
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
14734530 GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
20371612 GOA
enables beta-catenin binding IPI
IPI: Inferred from physical interaction
15905404 GOA
enables mitochondrial transcription factor activity IMP
IMP: Inferred from mutant phenotype
29445193 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10102273 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
16751106 GOA
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
10102273 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to glucose starvation IDA
IDA: Inferred from direct assay
29445193 GOA
involved in mitochondrial transcription IMP
IMP: Inferred from mutant phenotype
29445193 GOA
involved in negative regulation of cell migration IMP
IMP: Inferred from mutant phenotype
19188590 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
18393360 GOA
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
18787191 GOA
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
10102273 GOA
involved in positive regulation of apoptotic process IDA
IDA: Inferred from direct assay
20371612 GOA
acts upstream of or within positive regulation of erythrocyte differentiation IDA
IDA: Inferred from direct assay
14734530 GOA
involved in positive regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
10102273 GOA
involved in positive regulation of regulatory T cell differentiation IDA
IDA: Inferred from direct assay
30513302 GOA
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
14734530 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
10102273 GOA
involved in regulation of translation IDA
IDA: Inferred from direct assay
21329882 GOA
involved in tumor necrosis factor-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
15084260 GOA
Cellular Component GO Annotation Evidence Reference Source
part of RNA polymerase II transcription repressor complex IPI
IPI: Inferred from physical interaction
18393360 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
10102273 GOA
located in cytosol IDA
IDA: Inferred from direct assay
23640897 GOA
colocalizes with mitochondrial matrix IDA
IDA: Inferred from direct assay
29445193 GOA
located in mitochondrial outer membrane IDA
IDA: Inferred from direct assay
29445193 GOA
colocalizes with mitochondrion IDA
IDA: Inferred from direct assay
23283301 GOA
located in nucleus IDA
IDA: Inferred from direct assay
10102273 GOA
located in nucleus IMP
IMP: Inferred from mutant phenotype
29445193 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
23283301 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FOXO3 Protein Structure

Forkhead

Forkhead: Forkhead domain (160 - 241)

  • 0
  • 200
  • 400
  • 600
  • 673 a.a.
Protein Preferred Names Protein Names

forkhead box protein O3

FOXO3A-

FOXO3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra FOXO3 O43524 PNKP Homo sapiens Q96T60
TAP
25609649
Cross FOXO3 O43524 Foxg1 Mus musculus Q60987
Anti Tag CoIP
15084259
Cross FOXO3 O43524 Foxg1 Mus musculus Q60987
Pull Down
15084259
Intra FOXO3 O43524 TAF5L Homo sapiens O75529
TAP
25609649
Intra FOXO3 O43524 SIRT1 Homo sapiens Q96EB6
Anti Bait CoIP
15126506
Intra FOXO3 O43524 SIRT1 Homo sapiens Q96EB6
Anti Bait CoIP
14976264
Intra FOXO3 O43524 FOXK1 Homo sapiens P85037
TAP
25609649
Intra FOXO3 O43524 ARHGEF2 Homo sapiens Q92974
TAP
25609649
Intra FOXO3 O43524 YWHAZ Homo sapiens P63104
Anti Tag CoIP
10102273
Intra FOXO3 O43524 YWHAZ Homo sapiens P63104
Anti Tag CoIP
11864996
Intra FOXO3 O43524 SMAD3 Homo sapiens P84022
Anti Tag CoIP
15084259
Intra FOXO3 O43524 SMAD3 Homo sapiens P84022
Pull Down
15084259
Intra FOXO3 O43524 SMAD4 Homo sapiens Q13485
Anti Bait CoIP
21532621
Intra FOXO3 O43524 SMAD4 Homo sapiens Q13485
Anti Tag CoIP
15084259
Intra FOXO3 O43524 SMAD4 Homo sapiens Q13485
Pull Down
15084259
Cross FOXO3 O43524 Ywhaz Mus musculus P63101
Affinity Techniques
21621563
Intra FOXO3 O43524 YWHAE Homo sapiens P62258
Anti Tag CoIP
20562859
Intra FOXO3 O43524 YWHAE Homo sapiens P62258
Crosslink
36931259
Intra FOXO3 O43524 HCFC1 Homo sapiens P51610
Anti Tag CoIP
21909281
Intra FOXO3 O43524 MYC Homo sapiens P01106
Anti Tag CoIP
18393360
Intra FOXO3 O43524 MYC Homo sapiens P01106
Anti Bait CoIP
18393360
Intra FOXO3 O43524 RB1 Homo sapiens P06400
TAP
25609649
Intra FOXO3 O43524 ESR1 Homo sapiens P03372
Anti Bait CoIP
18312651
Intra FOXO3 O43524 ESR1 Homo sapiens P03372
Pull Down
18312651
Intra FOXO3 O43524 ESR1 Homo sapiens P03372
SIA
18312651
Intra FOXO3 O43524 ESR1 Homo sapiens P03372
Anti Tag CoIP
18312651
Intra FOXO3 O43524 ESR2 Homo sapiens Q92731
Anti Tag CoIP
18312651
Intra FOXO3 O43524 ESR2 Homo sapiens Q92731
Anti Bait CoIP
18312651
Intra FOXO3 O43524 ESR2 Homo sapiens Q92731
Pull Down
18312651
Intra FOXO3 O43524 CREBBP Homo sapiens Q92793
TAP
25609649
Intra FOXO3 O43524 RBL1 Homo sapiens P28749
TAP
25609649
Intra FOXO3 O43524 CDC27 Homo sapiens P30260
TAP
25609649
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Aging
Rhabdomyosarcoma
Leukemia

Leukemias

Leukaemia, Unspecified, Without Mention Of Remission

Aleukemic Leukaemia

Chronic Leukaemia

Subacute Leukaemia

Leukaemia Disorder

Leukaemia Nos

Myeloid Leukemia

Myeloid Leukaemia

Leukaemia Myelogenous

Leukemia Myelogenous

Myeloid Granulocytic Leukaemia

Myeloid Granulocytic Leukemia

Non-Lymphocytic Leukemia

Leukemia, Myeloid

Granulocytic Leukaemia

Myelogenous Leukaemia

Myeloid Leukaemia, Unspecified, Without Mention Of Remission

Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma

Adenoid Cystic Carcinoma

Adenocystic Carcinoma

Cribriform Carcinoma

Cylindroma

Carcinoma Adenoid Cystic

Carcinoma, Adenoid Cystic

Adenoid Cystic Carcinoma Of Salivary Gland

Eccrine Dermal Cylindroma

Carcinoma, Cribriform

Glioblastoma

Glioblastoma Multiforme

Gbm

Adult Glioblastoma Multiforme

Grade Iv Adult Astrocytic Tumor

Primary Glioblastoma Multiforme

Spongioblastoma Multiforme

Adult Glioblastoma

Primary Glioblastoma

Huntington Disease

Huntington'S Disease

Huntington Chorea

Huntington'S Chorea

HD

Huntington Chronic Progressive Hereditary Chorea

Juvenile Huntington Disease

Chronic Progressive Chorea

Chronic Progressive Hereditary Chorea

Hc - [Huntington Chorea]

Hereditary Chorea

Progressive Hereditary Chorea

Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer

Premature Menopause

Primary Ovarian Insufficiency

Premature Ovarian Failure

Hypergonadotropic Hypogonadism

Premature Ovarian Insufficiency

Menopause - Premature

Menopause Praecox

Menopause Premature

Menopause, Premature

Female Hypergonadotropic Hypogonadism

Hypergonadotrophic Ovarian Failure

Primary Female Hypogonadism

Pof - [Premature Ovarian Failure]

Ovarian Failure

Ovarian Secretion Suppression

Ovary Hyposecretion

Ovary Secretion Deficiency

Premature Menopause Nos

Endometrial Cancer

Endometrial Carcinoma

Endometrial Neoplasm

Malignant Neoplasm Of Endometrium

Endometrioid Carcinoma

Endometrial Neoplasms

Carcinoma, Endometrioid

Endometrial Cancer, Familial

Endometrial Carcinoma, Somatic

Endometrial Cancer, Susceptibility To

Endometrial Ca

Malignant Endometrial Neoplasm

Neoplasm Of Endometrium

Primary Malignant Neoplasm Of Endometrium

Tumor Of Endometrium

Carcinoma Of The Endometrium

Endometrioid Carcinoma Of Female Reproductive System

ENDMC

Carcinoma Endometrioid

Endometrial Cancers

Cancer, Endometrial

Uterine Corpus Cancer

Leukemia, Chronic Myeloid

Chronic Myeloid Leukemia

Chronic Myelogenous Leukemia

CML

Chronic Granulocytic Leukemia

Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib

Chronic Myeloid Leukaemia

Chronic Granulocytic Leukaemia

Chronic Myelogenous Leukaemia

Myeloid Leukemia, Chronic

Leukemia, Chronic Myelogenous

Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic

Cml - Chronic Myelogenous Leukemia

Cgl

Chronic Myelocytic Leukemia

Leukemia, Chronic Myeloid, Atypical

ACML

Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative

Myeloid Leukemia Chronic

Leukemia, Myeloid, Chronic

Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative

Cml- [Chronic Myeloid Leukaemia]

Cgl - [Chronic Granulocytic Leukaemia]

Chronic Myelocytic Leukaemia

Neural Tube Defects

Spina Bifida

Neural Tube Defect

NTD

Neural Tube Defects, Susceptibility To

Spinal Dysraphism

Spina Bifida, Susceptibility To

Rachischisis

Cleft Spine

Open Spine

Hydrocele Spinalis

Neural Tube Defect Nos

Sb - [Spina Bifida]

Spinal Hernia Nos

Spinal Fissure Nos

Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Microphthalmia

Microphthalmos

Isolated Anophthalmia-Microphthalmia Syndrome

Isolated Microphthalmia-Anophthalmia-Coloboma

Simple Microphthalmos

Clinical Anophthalmia

Isolated Anophthalmia - Microphthalmia

Isolated Pure Microphthalmia

Mac Spectrum

Microphthalmia-Anophthalmia-Coloboma Spectrum

Primitive Anophthalmia

Globe Of Eye Small

Small Eyeball

Hypoplasia Of Eye

Isolated Nanophthalmos

Rudimentary Eye

Dysplasia Of Eye

Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]

Neuroblastoma

Nb

Neuroblastoma, Susceptibility To

Neuroblastomas

Central Neuroblastoma

Osteoporosis

Postmenopausal Osteoporosis

Osteoporosis, Postmenopausal

Bone Mineral Density Quantitative Trait Locus

Bmnd

Osteoporosis, Involutional

Osteoporosis, Susceptibility To

Osteoporosis, Postmenopausal, Susceptibility

Bone Mineral Density Variation Qtl, Osteoporosis

OSTEOP

Involutional Osteoporosis

Senile Osteoporosis

Osteoporosis Postmenopausal

Bone Mineral Density, Quantitative Trait Locus

Osteoporosis, Senile

Idiopathic Osteoporosis

Bone Rarefaction Nos

Type 1 Osteoporosis

Intrahepatic Gall Duct Cancer

Malignant Neoplasm Of Intrahepatic Bile Ducts

Malignant Neoplasm Of Intrahepatic Gall Duct

Ca Intrahepatic Bile Ducts

Malignant Neoplasm Of Intrahepatic Biliary Passages

Intrahepatic Bile Duct Carcinoma

Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary

Diabetes Mellitus

Diabetes

Cataract

Cataracts

Cat - [Cataract]

Cataract Form

Lens Opacity

Lens Opacities

Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Nervous System Disease

Abnormality Of The Nervous System

Nervous System Diseases

Nervous System Disorder

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Mus musculus FOXO3 MGD MGI:1890081
Felis catus FOXO3 VGNC VGNC:62344
Bos taurus FOXO3 VGNC VGNC:29099
Canis familiaris FOXO3 VGNC VGNC:40963
Macaca mulatta FOXO3 VGNC VGNC:72704
Rattus norvegicus FOXO3 RGD RGD:1309196
Others FOXO3 NCBI