Ulk1 - unc-51 like kinase 1 Gene

Mus musculus

Also known as Unc51.1; mKIAA0722

Gene ID: 22241 | Gene type: protein coding

About Ulk1

Chromosome 5: 110,932,354-110,957,963 reverse strand.GRCm39:CM000998.3

This gene has 11 transcripts (splice variants), 202 orthologues, 2 paralogues and is associated with 10 phenotypes. Ubiquitous expression in thymus adult (RPKM 26.1), adrenal adult (RPKM 23.6) and 28 other tissues.

Summary

Enables HSP90 protein binding activity; protein kinase binding activity; and protein serine/threonine kinase activity. Involved in several processes, including cellular response to amino acid starvation; macroautophagy; and response to mitochondrial depolarisation. Acts upstream of or within several processes, including nervous system development; protein autophosphorylation; and regulation of neurotrophin Trk Receptor signaling pathway. Located in several cellular components, including cytoplasmic vesicle membrane; neuronal cell body; and phagophore assembly site membrane. Part of Atg1/ULK1 kinase complex. Is expressed in several structures, including central nervous system and retina. Orthologous to human ULK1 (unc-51 like Autophagy activating kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Ulk1 Products(2)

mRNA	Protein	Name
NM_001347394.1	NP_001334323.1	serine/threonine-protein kinase ULK1 isoform 1
NM_009469.3	NP_033495.2	serine/threonine-protein kinase ULK1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables Hsp90 protein binding	IPI IPI: Inferred from physical interaction	21855797	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15014045	MGI
enables protein kinase activity	IDA IDA: Inferred from direct assay	9600096	MGI
enables protein kinase activity	IMP IMP: Inferred from mutant phenotype	22539723	MGI
enables protein kinase binding	IPI IPI: Inferred from physical interaction	21258367	MGI
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	18443221	MGI
enables protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	21855797	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within Ras protein signal transduction	IDA IDA: Inferred from direct assay	15014045	MGI
involved in autophagosome assembly	IDA IDA: Inferred from direct assay	19225151	MGI
involved in autophagosome assembly	IMP IMP: Inferred from mutant phenotype	19258318	MGI
involved in autophagy	IMP IMP: Inferred from mutant phenotype	18443221	MGI
acts upstream of or within axon extension	IMP IMP: Inferred from mutant phenotype	17389358	MGI
acts upstream of or within axon guidance	IMP IMP: Inferred from mutant phenotype	29099309	MGI
acts upstream of or within axonogenesis	IDA IDA: Inferred from direct assay	15014045	MGI
involved in cellular response to amino acid starvation	IGI IGI: Inferred from genetic interaction	21855797	MGI
involved in cellular response to nutrient levels	IDA IDA: Inferred from direct assay	21258367	MGI
acts upstream of or within cerebellar granule cell differentiation	IMP IMP: Inferred from mutant phenotype	10624947	MGI
acts upstream of collateral sprouting	IMP IMP: Inferred from mutant phenotype	17389358	MGI
acts upstream of or within establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	17389358	MGI
involved in macroautophagy	IGI IGI: Inferred from genetic interaction	21855797	MGI
acts upstream of or within macroautophagy	IMP IMP: Inferred from mutant phenotype	21258367	MGI
involved in mitophagy	IMP IMP: Inferred from mutant phenotype	21855797	MGI
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	21795849	MGI
acts upstream of or within negative regulation of collateral sprouting	IMP IMP: Inferred from mutant phenotype	17389358	MGI
acts upstream of or within neuron migration	IMP IMP: Inferred from mutant phenotype	10624947	MGI
acts upstream of or within neuron projection development	IMP IMP: Inferred from mutant phenotype	10624947	MGI
involved in peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	21855797	MGI
involved in positive regulation of autophagy	IDA IDA: Inferred from direct assay	19225151	MGI
involved in positive regulation of autophagy	IMP IMP: Inferred from mutant phenotype	22539723	MGI
acts upstream of or within protein autophosphorylation	IDA IDA: Inferred from direct assay	9600096	MGI
acts upstream of or within protein localization	IGI IGI: Inferred from genetic interaction	29099309	MGI
acts upstream of or within radial glia guided migration of cerebellar granule cell	IMP IMP: Inferred from mutant phenotype	10624947	MGI
acts upstream of or within receptor internalization	IMP IMP: Inferred from mutant phenotype	17389358	MGI
involved in regulation of gene expression	IGI IGI: Inferred from genetic interaction	21855797	MGI
acts upstream of or within regulation of neurotrophin TRK receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	17389358	MGI
involved in regulation of protein lipidation	IDA IDA: Inferred from direct assay	19225151	MGI
involved in response to mitochondrial depolarisation	IMP IMP: Inferred from mutant phenotype	21855797	MGI
involved in response to starvation	IDA IDA: Inferred from direct assay	18443221	MGI
acts upstream of or within somatic sensory system development	IGI IGI: Inferred from genetic interaction	29099309	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of Atg1/ULK1 kinase complex	IDA IDA: Inferred from direct assay	19211835	MGI
part of Atg1/ULK1 kinase complex	IPI IPI: Inferred from physical interaction	19258318	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	10624947	MGI
located in cytoplasmic vesicle membrane	IDA IDA: Inferred from direct assay	15014045	MGI
located in cytosol	IDA IDA: Inferred from direct assay	19258318	MGI
located in membrane	IDA IDA: Inferred from direct assay	15014045	MGI
located in neuron projection	IDA IDA: Inferred from direct assay	10624947	MGI
located in neuronal cell body	IDA IDA: Inferred from direct assay	10624947	MGI
located in phagophore assembly site	IDA IDA: Inferred from direct assay	18936157	MGI
located in phagophore assembly site membrane	IDA IDA: Inferred from direct assay	18443221	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ulk1 Protein Structure

STKc_ULK1

DUF3543

0
200
400
600
800
1051 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase ULK1

serine/threonine-protein kinase Unc51.1

Related Agents

Pre-clinical Phase

Bioactive Molecules (17)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16966	SBI-0206965	Inhibitor	99.92%	Unkown
HY-13018	MRT67307	Inhibitor	99.44%	Unkown
HY-114490	ULK-101	Inhibitor	99.96%	Unkown
HY-124729	BL-918	Activator	99.98%	Unkown
HY-160699	DCC-3116	Inhibitor	99.25%	Unkown
HY-137742	SBP-7455	Inhibitor	98.24%	Unkown
HY-148063	DB0614		98.80%	Unkown
HY-143466	ULK1-IN-2	Inhibitor	99.09%	Unkown
HY-137506	XST-14	Inhibitor	99.26%	Unkown
HY-148061	DB1113		99.28%	Unkown
HY-101923A	LYN-1604 hydrochloride	Activator	/	Unkown
HY-13018A	MRT67307 hydrochloride	Inhibitor	/	Unkown
HY-101923	LYN-1604	Activator	99.41%	Unkown
HY-158408	NZ-66		/	Unkown
HY-161850	ULK1-IN-3	Inhibitor	/	Unkown
HY-162100	MR-2088	Inhibitor	/	Unkown
HY-117413	SR-17398	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ulk1	NCBI	NCBI:8408

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