ULK1 - unc-51 like autophagy activating kinase 1 Gene

Homo sapiens

Also known as ATG1; ATG1A; UNC51; hATG1; Unc51.1

Gene ID: 8408 | Gene type: protein coding

About ULK1

Cytogenetic location: 12q24.33 Genomic coordinates (GRCh38): 12:131,894,622-131,923,150 (from NCBI)

This gene has 7 transcripts (splice variants), 202 orthologues and 2 paralogues. Ubiquitous expression in bone marrow (RPKM 14.9), endometrium (RPKM 11.7) and 25 other tissues.

Summary

Enables identical protein binding activity; protein serine/threonine kinase activity; and small GTPase binding activity. Involved in several processes, including autophagosome assembly; positive regulation by symbiont of host autophagy; and protein phosphorylation. Located in autophagosome; cytosol; and phagophore assembly site membrane. Is extrinsic component of autophagosome membrane; extrinsic component of omegasome membrane; and extrinsic component of phagophore assembly site membrane. Part of Atg1/ULK1 kinase complex. [provided by Alliance of Genome Resources, Apr 2022]

ULK1 Products(4)

mRNA	Protein	Name
XM_011538799.3	XP_011537101.1	serine/threonine-protein kinase ULK1 isoform X2
XM_011538798.4	XP_011537100.1	serine/threonine-protein kinase ULK1 isoform X1
XR_007063134.1
NM_003565.4	NP_003556.2	serine/threonine-protein kinase ULK1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTPase binding	IPI IPI: Inferred from physical interaction	25891078	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	20562859	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11146101	GOA
enables protein serine/threonine kinase activity	EXP EXP: Inferred from Experiment	32320653	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	18936157	GOA
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	19211835	GOA
enables small GTPase binding	IPI IPI: Inferred from physical interaction	22613832	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in autophagosome assembly	IDA IDA: Inferred from direct assay	19225151	GOA
involved in autophagy	IDA IDA: Inferred from direct assay	18936157	GOA
involved in autophagy	IGI IGI: Inferred from genetic interaction	28389568	GOA
involved in autophagy	IMP IMP: Inferred from mutant phenotype	17595159	GOA
involved in cellular response to stress	IDA IDA: Inferred from direct assay	25891078	GOA
involved in macroautophagy	IMP IMP: Inferred from mutant phenotype	22354037	GOA
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	21795849	GOA
involved in negative regulation of protein-containing complex assembly	IDA IDA: Inferred from direct assay	25126726	GOA
involved in neuron projection development	IMP IMP: Inferred from mutant phenotype	18007665	GOA
involved in peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	25126726	GOA
involved in peptidyl-threonine phosphorylation	IDA IDA: Inferred from direct assay	27103069	GOA
involved in positive regulation of autophagy	IDA IDA: Inferred from direct assay	25126726	GOA
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	18936157	GOA
involved in protein localization	IMP IMP: Inferred from mutant phenotype	16940348	GOA
involved in regulation of macroautophagy	IDA IDA: Inferred from direct assay	20921139	GOA
involved in regulation of protein lipidation	IDA IDA: Inferred from direct assay	19225151	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Atg1/ULK1 kinase complex	IPI IPI: Inferred from physical interaction	19211835	GOA
located in autophagosome	IDA IDA: Inferred from direct assay	17595159	GOA
located in autophagosome membrane	IDA IDA: Inferred from direct assay	22885598	GOA
is active in cytoplasm	IDA IDA: Inferred from direct assay	29487085	GOA
located in cytosol	IDA IDA: Inferred from direct assay	11146101	GOA
located in omegasome membrane	IDA IDA: Inferred from direct assay	22885598	GOA
located in phagophore assembly site	IDA IDA: Inferred from direct assay	19597335	GOA
located in phagophore assembly site membrane	IDA IDA: Inferred from direct assay	18936157	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ULK1 Protein Structure

Pkinase

DUF3543

0
200
400
600
800
1050 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase ULK1

ATG1 autophagy related 1 homolog

autophagy-related protein 1 homolog

ULK1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ULK1	O75385	NTRK1	Homo sapiens	P04629	Anti Tag CoIP	17389358
Intra	ULK1	O75385	RB1CC1	Homo sapiens	Q8TDY2	Pull Down	32707033
Intra	ULK1	O75385	RB1CC1	Homo sapiens	Q8TDY2	Anti Bait CoIP	23524951
Intra	ULK1	O75385	RB1CC1	Homo sapiens	Q8TDY2	Anti Tag CoIP	35271311
Intra	ULK1	O75385	RB1CC1	Homo sapiens	Q8TDY2	Anti Tag CoIP	20562859
Intra	ULK1	O75385	RB1CC1	Homo sapiens	Q8TDY2	Anti Tag CoIP	25686248
Intra	ULK1	O75385	RB1CC1	Homo sapiens	Q8TDY2	Anti Tag CoIP	33422265
Intra	ULK1	O75385	RB1CC1	Homo sapiens	Q8TDY2	Crosslink	23392225
Intra	ULK1	O75385	RPTOR	Homo sapiens	Q8N122	Anti Tag CoIP	25686248
Intra	ULK1	O75385	AMBRA1	Homo sapiens	Q9C0C7-3	Anti Tag CoIP	23524951
Intra	ULK1	O75385	AMBRA1	Homo sapiens	Q9C0C7-3	Anti Bait CoIP	23524951
Intra	ULK1	O75385	C9orf72	Homo sapiens	Q96LT7-1	Pull Down	27334615
Intra	ULK1	O75385	C9orf72	Homo sapiens	Q96LT7-1	PLA	27334615
Intra	ULK1	O75385	C9orf72	Homo sapiens	Q96LT7-1	Anti Tag CoIP	27334615
Intra	ULK1	O75385	C9orf72	Homo sapiens	Q96LT7-2	PLA	27334615
Intra	ULK1	O75385	C9orf72	Homo sapiens	Q96LT7-2	Anti Tag CoIP	27334615
Intra	ULK1	O75385	C9orf72	Homo sapiens	Q96LT7-2	Pull Down	27334615
Intra	ULK1	O75385	AMBRA1	Homo sapiens	Q9C0C7	Anti Bait CoIP	23524951
Intra	ULK1	O75385	MAP1LC3C	Homo sapiens	Q9BXW4	Pull Down	20562859
Intra	ULK1	O75385	TBC1D14	Homo sapiens	Q9P2M4	Y2H	22613832
Intra	ULK1	O75385	TBC1D14	Homo sapiens	Q9P2M4	Anti Tag CoIP	22613832
Intra	ULK1	O75385	ATG13	Homo sapiens	O75143	Anti Bait CoIP	23524951
Intra	ULK1	O75385	ATG13	Homo sapiens	O75143	Anti Tag CoIP	33450483
Intra	ULK1	O75385	ATG13	Homo sapiens	O75143	Anti Tag CoIP	25686248
Intra	ULK1	O75385	ATG13	Homo sapiens	O75143	Anti Tag CoIP	20562859
Intra	ULK1	O75385	ATG13	Homo sapiens	O75143	Crosslink	23392225
Intra	ULK1	O75385	ATG13	Homo sapiens	O75143	Anti Tag CoIP	33422265
Intra	ULK1	O75385	ATG13	Homo sapiens	O75143	Pull Down	32707033
Intra	ULK1	O75385	MTOR	Homo sapiens	P42345	Anti Bait CoIP	23524951
Intra	ULK1	O75385	MTOR	Homo sapiens	P42345	Anti Bait CoIP	25686248
Intra	ULK1	O75385	MTOR	Homo sapiens	P42345	Anti Tag CoIP	25686248
Intra	ULK1	O75385	TRAF6	Homo sapiens	Q9Y4K3	Anti Bait CoIP	23524951
Intra	ULK1	O75385	MAP1LC3B	Homo sapiens	Q9GZQ8	Pull Down	20562859
Intra	ULK1	O75385	HTT	Homo sapiens	P42858	Anti Bait CoIP	25686248
Intra	ULK1	O75385	HTT	Homo sapiens	P42858	Anti Tag CoIP	25686248
Intra	ULK1	O75385	PRKAB1	Homo sapiens	Q9Y478	Anti Tag CoIP	25686248
Intra	ULK1	O75385	PRKAB1	Homo sapiens	Q9Y478	Anti Bait CoIP	21072212
Intra	ULK1	O75385	GABARAPL2	Homo sapiens	P60520	Pull Down	20562859
Intra	ULK1	O75385	GABARAPL2	Homo sapiens	P60520	Anti Tag CoIP	20562859
Intra	ULK1	O75385	GABARAPL1	Homo sapiens	Q9H0R8	Pull Down	20562859

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Neurodegeneration With Brain Iron Accumulation

Nbia	Neurodegeneration With Brain Iron Accumulation Disorders
Neurodegeneration, With Brain Iron Accumulation

Acute Laryngopharyngitis

Pharyngolaryngitis	Laryngopharyngitis
Hypopharyngitis

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (17)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16966	SBI-0206965	Inhibitor	99.39%	Unkown
HY-13018	MRT67307	Inhibitor	99.34%	Unkown
HY-114490	ULK-101	Inhibitor	99.96%	Unkown
HY-124729	BL-918	Activator	99.98%	Unkown
HY-160699	DCC-3116	Inhibitor	99.25%	Unkown
HY-137742	SBP-7455	Inhibitor	98.24%	Unkown
HY-143466	ULK1-IN-2	Inhibitor	99.09%	Unkown
HY-148063	DB0614		98.80%	Unkown
HY-137506	XST-14	Inhibitor	99.26%	Unkown
HY-148061	DB1113		99.28%	Unkown
HY-101923A	LYN-1604 hydrochloride	Activator	/	Unkown
HY-13018A	MRT67307 hydrochloride	Inhibitor	/	Unkown
HY-101923	LYN-1604	Activator	/	Unkown
HY-158408	NZ-66		/	Unkown
HY-161850	ULK1-IN-3	Inhibitor	/	Unkown
HY-162100	MR-2088	Inhibitor	/	Unkown
HY-117413	SR-17398	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ULK1	VGNC	VGNC:36658
Mus musculus	ULK1	MGD	MGI:1270126
Canis familiaris	ULK1	VGNC	VGNC:48128
Macaca mulatta	ULK1	VGNC	VGNC:78715
Felis catus	ULK1	VGNC	VGNC:66814
Rattus norvegicus	ULK1	RGD	RGD:1589743

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