2. Gene
  3. XRN2 - 5'-3' exoribonuclease 2 Gene

XRN2 - 5'-3' exoribonuclease 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 22803 | Gene type: protein coding

About XRN2

Cytogenetic location: 20p11.22 Genomic coordinates (GRCh38): 20:21,303,331-21,389,825 (from NCBI)

This gene has 1 transcript (splice variant), 212 orthologues and 1 paralogue. Ubiquitous expression in appendix (RPKM 21.1), thyroid (RPKM 20.8) and 25 other tissues.

Summary

This gene encodes a 5'-3' exonuclease that promotes transcription termination at cotranscriptional cleavage sites. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

XRN2 Products(2)

mRNA Protein Name
NM_001317960.1 NP_001304889.1 5'-3' exoribonuclease 2 isoform 1
NM_012255.5 NP_036387.2 5'-3' exoribonuclease 2 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables 3'-5'-RNA exonuclease activity EXP
EXP: Inferred from Experiment
23482395 GOA
enables 5'-3' exonuclease activity IDA
IDA: Inferred from direct assay
15565158 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15231747 GOA
enables transcription termination site sequence-specific DNA binding IDA
IDA: Inferred from direct assay
21700224 GOA
Biological Process GO Annotation Evidence Reference Source
involved in spermatogenesis IEP
IEP: Inferred from expression pattern
10409438 GOA
involved in termination of RNA polymerase II transcription IMP
IMP: Inferred from mutant phenotype
15565158 GOA
Cellular Component GO Annotation Evidence Reference Source
located in nucleolus IDA
IDA: Inferred from direct assay
12429849 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

XRN2 Protein Structure

XRN_N

XRN_N: XRN 5'-3' exonuclease N-terminus (1 - 255)

  • 0
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  • 800
  • 950 a.a.
Protein Preferred Names Protein Names

5'-3' exoribonuclease 2

DHM1-like protein

XRN2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
XRN2 Q9H0D6 CDKN2AIPNL Homo sapiens Q96HQ2
Anti Tag CoIP
34591612
Intra
XRN2 Q9H0D6 LCN2 Homo sapiens P80188
Y2H Prey Pooling
32296183
Intra
XRN2 Q9H0D6 LCN2 Homo sapiens P80188
Y2H Array
32296183
Intra
XRN2 Q9H0D6 CDKN2AIP Homo sapiens Q9NXV6
Anti Tag CoIP
34591612
Intra
XRN2 Q9H0D6 DISC1 Homo sapiens Q9NRI5
Y2H
17043677
Intra
XRN2 Q9H0D6 TARDBP Homo sapiens Q13148
Y2H
15231747
Intra
XRN2 Q9H0D6 PLEKHF2 Homo sapiens Q9H8W4
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Amyotrophic Lateral Sclerosis 4, Juvenile

Amyotrophic Lateral Sclerosis Type 4

ALS4

Amyotrophic Lateral Sclerosis 4

Dhmn With Upper Motor Neuron Signs

Distal Hereditary Motor Neuropathy With Upper Motor Neuron Signs

Neuronopathy, Distal Hereditary Motor, With Pyramidal Features

Als 4

Distal Hereditary Motor Neuropathy With Pyramidal Features

Amyotrophic Lateral Sclerosis Juvenile 4

Neuronopathy Distal Hereditary Motor With Pyramidal Features

Sclerosis, Lateral, Amyotrophic, Type Type 4
Spinocerebellar Ataxia, Autosomal Recessive, With Axonal Neuropathy 2

Aoa2

Ataxia With Oculomotor Apraxia Type 2

Scar1

SCAN2

Ataxia-Oculomotor Apraxia 2

Ataxia-Ocular Apraxia 2

Ataxia-Oculomotor Apraxia Type 2

Scan 2

Spinocerebellar Ataxia With Axonal Neuropathy Type 2

Spinocerebellar Ataxia, Autosomal Recessive 1, Formerly

Scar1, Formerly

Autosomal Recessive Spinocerebellar Ataxia-1

Spinocerebellar Ataxia, Autosomal Recessive, 1

Ataxia-Ocular Apraxia-2

Spinocerebellar Ataxia, Autosomal Recessive 1
Corneal Dystrophy, Posterior Polymorphous, 1

Posterior Polymorphous Corneal Dystrophy

Ppcd

Maumenee Corneal Dystrophy

Posterior Polymorphous Corneal Dystrophy 1

PPCD1

Corneal Dystrophy, Hereditary Polymorphous Posterior

Corneal Endothelial Dystrophy 1, Autosomal Dominant

Schlichting Dystrophy

Ched1

Corneal Endothelial Dystrophy 1, Autosomal Dominant, Formerly

Ched1, Formerly

Hereditary Polymorphus Posterior Corneal Dystrophy

Posterior Polymorphous Dystrophy

Hereditary Polymorphous Posterior Corneal Dystrophy

Dystrophy, Corneal, Posterior Polymorphous

Dystrophy, Corneal, Posterior Polymorphous, Type 1

Polymorphous Corneal Dystrophy

Corneal Endothelial Dystrophy 2
Autism Spectrum Disorder

Asd

Autism Spectrum Disorders

Autistic Continuum

Pervasive Developmental Disorder

Pervasive Development Disorder

Autistic Behavior

Autistic Disorder

Autistic

Autistic Disorder Of Childhood Onset

Infantile Autism

Childhood Autism

Kanner Syndrome

Pervasive Developmental Delay Nos

Pervasive Developmental Disorder, Not Otherwise Specified
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15903 XRN2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta XRN2 VGNC VGNC:78814
Rattus norvegicus XRN2 RGD RGD:1310218
Felis catus XRN2 VGNC VGNC:67123
Mus musculus XRN2 MGD MGI:894687
Canis familiaris XRN2 VGNC VGNC:48472
Bos taurus XRN2 VGNC VGNC:37009