CDKN2AIP - CDKN2A interacting protein Gene

Homo sapiens

Also known as CARF

Gene ID: 55602 | Gene type: protein coding

About CDKN2AIP

Cytogenetic location: 4q35.1 Genomic coordinates (GRCh38): 4:183,444,636-183,449,064 (from NCBI)

This gene has 5 transcripts (splice variants), 210 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 11.6), bone marrow (RPKM 11.5) and 25 other tissues.

Summary

The protein encoded by this gene regulates the DNA damage response through several different signaling pathways. One such pathway is the p53-HDM2-p21(WAF1) pathway, which is critical to the DNA damage response. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

CDKN2AIP Products(2)

mRNA	Protein	Name
NM_001317343.2	NP_001304272.1	CDKN2A-interacting protein isoform 2
NM_017632.4	NP_060102.1	CDKN2A-interacting protein isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables p53 binding	IDA IDA: Inferred from direct assay	15109303	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12581788	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage response	IDA IDA: Inferred from direct assay	24825908	GOA
involved in negative regulation of cell growth	IMP IMP: Inferred from mutant phenotype	12154087	GOA
involved in positive regulation of cell growth	IMP IMP: Inferred from mutant phenotype	24825908	GOA
involved in positive regulation of signal transduction	IMP IMP: Inferred from mutant phenotype	15109303	GOA
involved in regulation of protein stability	IMP IMP: Inferred from mutant phenotype	12154087	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in granular component	IDA IDA: Inferred from direct assay	12154087	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	12154087	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	12154087	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDKN2AIP Protein Structure

XTBD

0
100
200
300
400
500
580 a.a.

Protein Preferred Names

Protein Names

CDKN2A-interacting protein

collaborates/cooperates with ARF (alternate reading frame) protein

CDKN2AIP Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CDKN2AIP	Q9NXV6	XRN2	Homo sapiens	Q9H0D6	Anti Tag CoIP	26496610
Intra	CDKN2AIP	Q9NXV6	XRN2	Homo sapiens	Q9H0D6	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Spleen Angiosarcoma

Angiosarcoma Of Spleen

Splenic Hemangiosarcoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02415	CDKN2AIP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CDKN2AIP	VGNC	VGNC:107317
Canis familiaris	CDKN2AIP	VGNC	VGNC:39070
Mus musculus	CDKN2AIP	MGD	MGI:1918175
Macaca mulatta	CDKN2AIP	VGNC	VGNC:100210
Rattus norvegicus	CDKN2AIP	RGD	RGD:1305302
Bos taurus	CDKN2AIP	VGNC	VGNC:106682

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