Trib3 - tribbles pseudokinase 3 Gene

Mus musculus

Also known as Nipk; SINK; Trb3; Ifld2; SKIP3; TRB-3

Gene ID: 228775 | Gene type: protein coding

About Trib3

Summary

Enables Enzyme binding activity; transcription corepressor activity; and ubiquitin-protein transferase regulator activity. Involved in several processes, including negative regulation of fat cell differentiation; negative regulation of fatty acid biosynthetic process; and regulation of protein modification process. Located in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; heart; and retina. Orthologous to human TRIB3 (tribbles pseudokinase 3). [provided by Alliance of Genome Resources, Apr 2022]

Trib3 Products(1)

mRNA	Protein	Name
NM_175093.2	NP_780302.2	tribbles homolog 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables enzyme binding	IPI IPI: Inferred from physical interaction	16794074	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12749859	MGI
enables protein kinase binding	IPI IPI: Inferred from physical interaction	12791994	MGI
enables transcription corepressor activity	IDA IDA: Inferred from direct assay	12749859	MGI
enables ubiquitin protein ligase binding	IDA IDA: Inferred from direct assay	20410507	MGI
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	16794074	MGI
enables ubiquitin-protein transferase regulator activity	IDA IDA: Inferred from direct assay	20410507	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to insulin stimulus	IDA IDA: Inferred from direct assay	12791994	MGI
involved in negative regulation of fat cell differentiation	IMP IMP: Inferred from mutant phenotype	17576771	MGI
involved in negative regulation of fatty acid biosynthetic process	IMP IMP: Inferred from mutant phenotype	16794074	MGI
involved in negative regulation of protein kinase activity	IDA IDA: Inferred from direct assay	12791994	MGI
involved in positive regulation of protein binding	IDA IDA: Inferred from direct assay	16794074	MGI
involved in positive regulation of ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	16794074	MGI
involved in regulation of D-glucose transmembrane transport	IDA IDA: Inferred from direct assay	12791994	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	12749859	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

tribbles homolog 3

induced in fatty liver dystrophy 2

neuronal cell death-inducible putative kinase

Trib3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Trib3	Q8K4K2	Akt1	Mus musculus	P31750	Y2H	12791994
Intra	Trib3	Q8K4K2	Akt1	Mus musculus	P31750	Anti Tag CoIP	12791994
Intra	Trib3	Q8K4K2	Akt1	Mus musculus	P31750	Pull Down	12791994
Intra	Trib3	Q8K4K2	Atf4	Mus musculus	Q06507	Anti Tag CoIP	12749859

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16261	Trib3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS15017	TRIB3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Trib3	NCBI	NCBI:57761

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