HABP4 - hyaluronan binding protein 4 Gene

Homo sapiens

Also known as IHABP4; IHABP-4; Ki-1/57; SERBP1L

Gene ID: 22927 | Gene type: protein coding

About HABP4

Cytogenetic location: 9q22.32 Genomic coordinates (GRCh38): 9:96,450,102-96,491,336 (from NCBI)

This gene has 3 transcripts (splice variants), 183 orthologues and 1 paralogue. Broad expression in brain (RPKM 24.4), testis (RPKM 16.9) and 22 other tissues.

Summary

Enables SUMO binding activity. Involved in PML body organization; negative regulation of DNA binding activity; and positive regulation of gene expression. Located in several cellular components, including Golgi apparatus; cytoplasmic stress granule; and nuclear lumen. [provided by Alliance of Genome Resources, Apr 2022]

HABP4 Products(1)

mRNA	Protein	Name
NM_014282.4	NP_055097.2	intracellular hyaluronan-binding protein 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables SUMO binding	IDA IDA: Inferred from direct assay	28695742	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15862299	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in PML body organization	IDA IDA: Inferred from direct assay	28695742	GOA
involved in negative regulation of DNA binding	IDA IDA: Inferred from direct assay	15862299	GOA
involved in positive regulation of RNA splicing	IMP IMP: Inferred from mutant phenotype	19523114	GOA
involved in positive regulation of translational initiation	IMP IMP: Inferred from mutant phenotype	21771594	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Cajal body	IDA IDA: Inferred from direct assay	19523114	GOA
located in Gemini of coiled bodies	IDA IDA: Inferred from direct assay	19523114	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	16879614	GOA
located in cytoplasmic stress granule	IDA IDA: Inferred from direct assay	21771594	GOA
located in nuclear speck	IDA IDA: Inferred from direct assay	19523114	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	19523114	GOA
located in nucleus	IDA IDA: Inferred from direct assay	16879614	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HABP4 Protein Structure

HABP4_PAI-RBP1

0
100
200
300
413 a.a.

Protein Preferred Names

Protein Names

intracellular hyaluronan-binding protein 4

chromodomain helicase DNA binding protein 3 interacting protein

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05983	HABP4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	HABP4	VGNC	VGNC:41581
Bos taurus	HABP4	VGNC	VGNC:29736
Rattus norvegicus	HABP4	RGD	RGD:1306486
Macaca mulatta	HABP4	VGNC	VGNC:73183
Mus musculus	HABP4	MGD	MGI:1891713
Felis catus	HABP4	VGNC	VGNC:62745

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