HABP4 - hyaluronan binding protein 4 Gene

Homo sapiens

Also known as IHABP4; IHABP-4; Ki-1/57; SERBP1L

Gene ID: 22927 | Gene type: protein coding

About HABP4

Cytogenetic location: 9q22.32 Genomic coordinates (GRCh38): 9:96,450,102-96,491,336 (from NCBI)

This gene has 3 transcripts (splice variants), 183 orthologues and 1 paralogue. Broad expression in brain (RPKM 24.4), testis (RPKM 16.9) and 22 other tissues.

Summary

Enables SUMO binding activity. Involved in PML body organization; negative regulation of DNA binding activity; and positive regulation of gene expression. Located in several cellular components, including Golgi apparatus; cytoplasmic stress granule; and nuclear lumen. [provided by Alliance of Genome Resources, Apr 2022]

HABP4 Products(1)

mRNA	Protein	Name
NM_014282.4	NP_055097.2	intracellular hyaluronan-binding protein 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables SUMO binding	IDA IDA: Inferred from direct assay	28695742	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15862299	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in PML body organization	IDA IDA: Inferred from direct assay	28695742	GOA
involved in negative regulation of DNA binding	IDA IDA: Inferred from direct assay	15862299	GOA
involved in positive regulation of RNA splicing	IMP IMP: Inferred from mutant phenotype	19523114	GOA
involved in positive regulation of translational initiation	IMP IMP: Inferred from mutant phenotype	21771594	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Cajal body	IDA IDA: Inferred from direct assay	19523114	GOA
located in Gemini of coiled bodies	IDA IDA: Inferred from direct assay	19523114	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	16879614	GOA
located in cytoplasmic stress granule	IDA IDA: Inferred from direct assay	21771594	GOA
located in nuclear speck	IDA IDA: Inferred from direct assay	19523114	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	19523114	GOA
located in nucleus	IDA IDA: Inferred from direct assay	16879614	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HABP4 Protein Structure

HABP4_PAI-RBP1

0
100
200
300
413 a.a.

Protein Preferred Names

Protein Names

intracellular hyaluronan-binding protein 4

chromodomain helicase DNA binding protein 3 interacting protein

HABP4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HABP4	Q5JVS0	SRSF9	Homo sapiens	Q13242	Pull Down	19523114
Intra	HABP4	Q5JVS0	PRMT1	Homo sapiens	Q99873	Y2H Pooling	16169070
Intra	HABP4	Q5JVS0	PRMT1	Homo sapiens	Q99873	Pull Down	16169070

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05983	HABP4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	HABP4	VGNC	VGNC:41581
Bos taurus	HABP4	VGNC	VGNC:29736
Rattus norvegicus	HABP4	RGD	RGD:1306486
Macaca mulatta	HABP4	VGNC	VGNC:73183
Mus musculus	HABP4	MGD	MGI:1891713
Felis catus	HABP4	VGNC	VGNC:62745

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