PRMT1 - protein arginine methyltransferase 1 Gene

Homo sapiens

Also known as ANM1; HCP1; IR1B4; HRMT1L2

Gene ID: 3276 | Gene type: protein coding

About PRMT1

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,676,153-49,688,447 (from NCBI)

This gene has 21 transcripts (splice variants), 206 orthologues and 7 paralogues. Ubiquitous expression in ovary (RPKM 42.8), heart (RPKM 38.0) and 25 other tissues.

Summary

This gene encodes a member of the protein arginine N-methyltransferase (PRMT) family. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to terminal guanidino nitrogen atoms. The encoded protein is a type I PRMT and is responsible for the majority of cellular arginine methylation activity. Increased expression of this gene may play a role in many types of Cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2011]

PRMT1 Products(9)

mRNA	Protein	Name
XM_047438742.1	XP_047294698.1	protein arginine N-methyltransferase 1 isoform X1
NR_033397.5
NM_198319.2
XM_017026735.2	XP_016882224.1	protein arginine N-methyltransferase 1 isoform X2
XM_017026736.2	XP_016882225.1	protein arginine N-methyltransferase 1 isoform X3
NM_001207042.3	NP_001193971.1	protein arginine N-methyltransferase 1 isoform 4
NM_001536.6	NP_001527.3	protein arginine N-methyltransferase 1 isoform 1
XM_047438743.1	XP_047294699.1	protein arginine N-methyltransferase 1 isoform X1
NM_198318.5	NP_938074.2	protein arginine N-methyltransferase 1 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables N-methyltransferase activity	IDA IDA: Inferred from direct assay	18657504	GOA
enables N-methyltransferase activity	IMP IMP: Inferred from mutant phenotype	19124016	GOA
enables S-adenosyl-L-methionine binding	IDA IDA: Inferred from direct assay	26876602	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	19460357	GOA
enables histone H4R3 methyltransferase activity	IDA IDA: Inferred from direct assay	11448779	GOA
enables histone H4R3 methyltransferase activity	IMP IMP: Inferred from mutant phenotype	25284789	GOA
enables histone methyltransferase activity	IDA IDA: Inferred from direct assay	19405910	GOA
enables identical protein binding	IDA IDA: Inferred from direct assay	26876602	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	16169070	GOA
enables methyl-CpG binding	IDA IDA: Inferred from direct assay	25284789	GOA
enables mitogen-activated protein kinase p38 binding	IPI IPI: Inferred from physical interaction	23483889	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8663146	GOA
enables protein methyltransferase activity	IDA IDA: Inferred from direct assay	19460357	GOA
enables protein methyltransferase activity	IMP IMP: Inferred from mutant phenotype	28040436	GOA
enables protein-arginine N-methyltransferase activity	EXP EXP: Inferred from Experiment	18316480	GOA
enables protein-arginine N-methyltransferase activity	IDA IDA: Inferred from direct assay	18495660	GOA
enables protein-arginine omega-N asymmetric methyltransferase activity	IDA IDA: Inferred from direct assay	15741314	GOA
enables protein-arginine omega-N asymmetric methyltransferase activity	IMP IMP: Inferred from mutant phenotype	25284789	GOA
enables protein-arginine omega-N monomethyltransferase activity	IDA IDA: Inferred from direct assay	26575292	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage response	IDA IDA: Inferred from direct assay	15741314	GOA
involved in cellular response to methionine	IDA IDA: Inferred from direct assay	38006878	GOA
involved in negative regulation of JNK cascade	IMP IMP: Inferred from mutant phenotype	22095282	GOA
involved in negative regulation of megakaryocyte differentiation	IDA IDA: Inferred from direct assay	20442406	GOA
involved in neuron projection development	IMP IMP: Inferred from mutant phenotype	18773938	GOA
involved in peptidyl-arginine methylation	IDA IDA: Inferred from direct assay	18657504	GOA
involved in positive regulation of TORC1 signaling	IDA IDA: Inferred from direct assay	38006878	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	28040436	GOA
involved in positive regulation of double-strand break repair via homologous recombination	IDA IDA: Inferred from direct assay	15741314	GOA
involved in positive regulation of erythrocyte differentiation	IMP IMP: Inferred from mutant phenotype	23483889	GOA
involved in positive regulation of translation	IDA IDA: Inferred from direct assay	30765518	GOA
involved in protein homooligomerization	IDA IDA: Inferred from direct assay	26876602	GOA
involved in protein methylation	IMP IMP: Inferred from mutant phenotype	26876602	GOA
involved in regulation of BMP signaling pathway	IDA IDA: Inferred from direct assay	33667543	GOA
involved in regulation of megakaryocyte differentiation	IDA IDA: Inferred from direct assay	26575292	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	26876602	GOA
is active in lysosomal membrane	IDA IDA: Inferred from direct assay	38006878	GOA
part of methylosome	IDA IDA: Inferred from direct assay	25284789	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10749851	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRMT1 Protein Structure

Methyltransf_31

0
100
200
300
371 a.a.

Protein Preferred Names

Protein Names

protein arginine N-methyltransferase 1

HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 2	heterogeneous nuclear ribonucleoprotein methyltransferase 1-like 2
highly conserved protein 1	histone-arginine N-methyltransferase PRMT1
interferon receptor 1-bound protein 4

PRMT1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PRMT1	Q99873	PRMT8	Homo sapiens	Q9NR22-2	Y2H Array	25416956
Intra	PRMT1	Q99873	PRMT8	Homo sapiens	Q9NR22-2	Y2H Prey Pooling	25416956
Intra	PRMT1	Q99873	SPEG	Homo sapiens	Q15772	Y2H Array	25416956
Intra	PRMT1	Q99873	SPSB2	Homo sapiens	Q99619	Anti Tag CoIP	23455924
Cross	PRMT1	Q99873	N	SARS-CoV-2	P0DTC9	Radiolabeled Methyl	34029587
Intra	PRMT1	Q99873	SPSB1	Homo sapiens	Q96BD6	Y2H	23455924
Intra	PRMT1	Q99873	VHL	Homo sapiens	P40337	Y2H	23455924
Intra	PRMT1	Q99873	H4C16	Homo sapiens	P62805	Methyltransferase Ass	21085121
Intra	PRMT1	Q99873	HNRNPK	Homo sapiens	P61978	Methyltransferase Ass	19101556
Intra	PRMT1	Q99873	CHTOP	Homo sapiens	Q9Y3Y2	Anti Bait CoIP	19858291
Intra	PRMT1	Q99873	HNRNPR	Homo sapiens	O43390	Y2H Array	31515488
Intra	PRMT1	Q99873	HNRNPR	Homo sapiens	O43390	Validated Y2H	25416956
Intra	PRMT1	Q99873	HNRNPR	Homo sapiens	O43390	Y2H Array	25416956
Intra	PRMT1	Q99873	NR4A1	Homo sapiens	P22736	Pull Down	19095693
Intra	PRMT1	Q99873	EWSR1	Homo sapiens	Q01844	Y2H	23455924
Intra	PRMT1	Q99873	DCAF8	Homo sapiens	Q5TAQ9	Y2H	23455924
Intra	PRMT1	Q99873	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	25416956
Intra	PRMT1	Q99873	PRMT8	Homo sapiens	Q9NR22	Anti Tag CoIP	23455924
Intra	PRMT1	Q99873	NRIP1	Homo sapiens	P48552	Anti Tag CoIP	17053781
Intra	PRMT1	Q99873	NRIP1	Homo sapiens	P48552	Enzymatic Study	17053781
Intra	PRMT1	Q99873	ILF3	Homo sapiens	Q12906	Pull Down	10749851
Intra	PRMT1	Q99873	PRMT1	Homo sapiens	Q99873	Y2H Array	25416956
Intra	PRMT1	Q99873	PRMT1	Homo sapiens	Q99873	Y2H	23455924
Intra	PRMT1	Q99873	PRMT1	Homo sapiens	Q99873	Y2H Pooling	16169070
Intra	PRMT1	Q99873	PRMT1	Homo sapiens	Q99873	Anti Tag CoIP	23455924
Intra	PRMT1	Q99873	FAM9A	Homo sapiens	Q8IZU1	Anti Tag CoIP	23455924

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Ewing Sarcoma

Neuroepithelioma	Ewing'S Tumor
Ewings Sarcoma	Ewing'S Sarcoma
Peripheral Neuroepithelioma	Primitive Neuroectodermal Tumor
ES	Ewings Sarcoma-Primitive Neuroectodermal Tumor
Localized Peripheral Primitive Neuroectodermal Tumor	Peripheral Primitive Neuroectodermal Tumor
Ewing Tumor	Sarcoma, Ewing'S
Extraosseous Ewing Tumor	Askin Tumor
Ewing'S Family Localized Tumor	Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor
Localized Ewing Sarcoma	Localized Ewing'S Sarcoma
Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor	Localized Ewing'S Tumor
Pnet Of Thoracopulmonary Region	Ewing Family Of Tumors
Tumor Of The Ewing Family	Skeletal Ewing Sarcoma
Osseous Ewing Sarcoma	Ppnet
Peripheral Pnet	Extraskeletal Ewing Sarcoma
Eoe	Extraosseous Ewing Sarcoma
Extraskeletal Ewing Tumor	Esft
Ewing Sarcoma Family Of Tumors	Pne
Pnet	Pnet Of The Chest Wall
Sarcoma, Ewing	Neuroectodermal Tumors, Primitive, Peripheral
Neuroectodermal Tumor, Primitive	Disorder Of Eye
Askin'S Tumor	Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor
Neuroepithelioma, Peripheral

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Spinal Cord Primitive Neuroectodermal Neoplasm

Spinal Cord Pnet

Spinal Cord Primitive Neuroectodermal Tumor

Encephalopathy, Neonatal Severe, Due To Mecp2 Mutations

Severe Congenital Encephalopathy Due To Mecp2 Mutation	Severe Neonatal-Onset Encephalopathy With Microcephaly
Encephalopathy, Neonatal Severe	Neonatal Severe Encephalopathy Due To Mecp2 Mutations
Mecp2-Related Severe Neonatal Encephalopathy	Methyl-Cytosine Phosphate Guanine Binding Protein 2 Related Severe Neonatal Encephalopathy
Severe Neonatal Encephalopathy Due To Mecp2 Mutations	ENS-MECP2
Encephalopathy, Neonatal, Severe

Spinal Cord Neuroblastoma

Neuroblastoma Of The Spinal Cord

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-128717	GSK3368715	Inhibitor	/	Phase 1
HY-128717B	GSK3368715 trihydrochloride	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (14)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19615	MS023	Inhibitor	99.73%	Unkown
HY-18962	AMI-1	Inhibitor	≥98.0%	Unkown
HY-12970A	EPZ020411 hydrochloride	Inhibitor	98.15%	Unkown
HY-12970	EPZ020411	Inhibitor	98.06%	Unkown
HY-110137	Furamidine dihydrochloride	Inhibitor	≥99.0%	Unkown
HY-107574	TC-E 5003	Inhibitor	98.03%	Unkown
HY-15890	C-7280948	Inhibitor	98.57%	Unkown
HY-19615B	MS023 dihydrochloride	Inhibitor	99.78%	Unkown
HY-122096	DCLX069	Inhibitor	98.03%	Unkown
HY-162230	PRMT5-IN-33	Inhibitor	/	Unkown
HY-164456	AMI-408	Inhibitor	/	Unkown
HY-161334	CARM1-IN-4	Inhibitor	/	Unkown
HY-149005	PRMT5-IN-19	Inhibitor	/	Unkown
HY-146810	PRMT4-IN-1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PRMT1	VGNC	VGNC:103742
Macaca mulatta	PRMT1	VGNC	VGNC:97809
Canis familiaris	PRMT1	VGNC	VGNC:44995
Mus musculus	PRMT1	MGD	MGI:107846
Bos taurus	PRMT1	VGNC	VGNC:52239
Rattus norvegicus	PRMT1	RGD	RGD:62020

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