NINL - ninein like Gene

Homo sapiens

Also known as NLP

Gene ID: 22981 | Gene type: protein coding

About NINL

Cytogenetic location: 20p11.21 Genomic coordinates (GRCh38): 20:25,452,697-25,585,531 (from NCBI)

This gene has 7 transcripts (splice variants), 176 orthologues and 1 paralogue. Broad expression in kidney (RPKM 4.4), ovary (RPKM 3.4) and 23 other tissues.

Summary

Predicted to enable calcium ion binding activity. Predicted to be involved in microtubule anchoring at centrosome. Located in cytosol; intercellular bridge; and microtubule Cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022]

NINL Products(2)

mRNA	Protein	Name
NM_001318226.2	NP_001305155.1	ninein-like protein isoform 2
NM_025176.6	NP_079452.3	ninein-like protein isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in centrosome	IDA IDA: Inferred from direct assay	26485514	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NINL Protein Structure

EF-hand_8

0
300
600
900
1200
1382 a.a.

Protein Preferred Names

Protein Names

ninein-like protein

NINL Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NINL	Q9Y2I6	CCHCR1	Homo sapiens	Q8TD31-3	Y2H Array	25416956
Intra	NINL	Q9Y2I6	CCDC146	Homo sapiens	Q8IYE0-2	Y2H Array	25416956
Intra	NINL	Q9Y2I6	HAUS1	Homo sapiens	Q96CS2	Y2H Prey Pooling	25416956
Intra	NINL	Q9Y2I6	KAT5	Homo sapiens	Q92993	Y2H Prey Pooling	25416956
Intra	NINL	Q9Y2I6	KAT5	Homo sapiens	Q92993	Y2H Array	25416956
Intra	NINL	Q9Y2I6	FAM161A	Homo sapiens	Q3B820	Validated Y2H	25416956
Intra	NINL	Q9Y2I6	RBM41	Homo sapiens	Q96IZ5	Validated Y2H	25416956
Intra	NINL	Q9Y2I6	RBM41	Homo sapiens	Q96IZ5	Y2H Array	25416956
Intra	NINL	Q9Y2I6	RCOR3	Homo sapiens	Q9P2K3	Validated Y2H	25416956
Intra	NINL	Q9Y2I6	RCOR3	Homo sapiens	Q9P2K3	Y2H Pooling	16189514
Intra	NINL	Q9Y2I6	SH2D4A	Homo sapiens	Q9H788	Validated Y2H	25416956
Intra	NINL	Q9Y2I6	L3MBTL4	Homo sapiens	Q8NA19	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Trichostrongylosis

Trichostrongyliasis	Infection By Trichostrongylus
Infection By Trichostrongylus Species	Trichostrongylus Infestation

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Hodgkin'S Lymphoma, Lymphocytic-Histiocytic Predominance

Hodgkin Disease	Hodgkin Lymphoma, Lymphocyte-Rich
Hodgkin Lymphoma, Lymphocytic-Histiocytic Predominance	Hodgkin'S Disease, Lymphocyte Predominance
Lymphocyte Rich Hodgkin'S Disease	Lymphocyte Rich Classical Hodgkin Lymphoma

Trichostrongyloidiasis

Hypotrichosis 1

HYPT1	Hhs
Hts	Hypotrichosis Simplex
Hypotrichosis Simplex, Generalized, Hereditary	Hereditary Generalized Hypotrichosis Simplex
Generalized Hypothricosis Simplex	Hypotrichosis Simplex Hereditary
Hypotrichosis, Type 1

Cone-Rod Dystrophy 2

Cone-Rod Dystrophy	CORD2
Cone-Rod Retinal Dystrophy	Rcrd2
Cone-Rod Retinal Dystrophy 2	Crd2
Cord	Crd
Retinal Cone-Rod Dystrophy	Cone-Rod Retinal Dystrophy-2
Retinal Cone-Rod Dystrophy 2	Tapetoretinal Degeneration
Cone-Rod Degeneration	Cone Rod Dystrophy
Dystrophy, Cone-Rod	Dystrophy, Cone-Rod, Type 2
Retinitis Pigmentosa	Retinitis Pigmentosa 2
Progressive Cone-Rod Dystrophy

Fundus Dystrophy

Retinal Dystrophy	Retinal Dystrophies
Dystrophy, Retinal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09300	NINL Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	NINL	MGD	MGI:1925427
Macaca mulatta	NINL	VGNC	VGNC:75273
Felis catus	NINL	VGNC	VGNC:63805
Canis familiaris	NINL	VGNC	VGNC:43813
Rattus norvegicus	NINL	RGD	RGD:1306152

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