SH2D4A - SH2 domain containing 4A Gene

Homo sapiens

Also known as SH2A; PPP1R38

Gene ID: 63898 | Gene type: protein coding

About SH2D4A

Cytogenetic location: 8p21.3 Genomic coordinates (GRCh38): 8:19,313,693-19,396,218 (from NCBI)

This gene has 6 transcripts (splice variants), 229 orthologues and 4 paralogues. Ubiquitous expression in ovary (RPKM 11.6), stomach (RPKM 9.2) and 22 other tissues.

Summary

Enables Phosphatase binding activity. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

SH2D4A Products(5)

mRNA	Protein	Name
NM_001174159.2	NP_001167630.1	SH2 domain-containing protein 4A isoform a
NM_001174160.2	NP_001167631.1	SH2 domain-containing protein 4A isoform b
NM_001363110.2	NP_001350039.1	SH2 domain-containing protein 4A isoform c
NM_001363111.2	NP_001350040.1	SH2 domain-containing protein 4A isoform c
NM_022071.4	NP_071354.2	SH2 domain-containing protein 4A isoform a

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables phosphatase binding	IDA IDA: Inferred from direct assay	19389623	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SH2D4A Protein Structure

SH2

0
100
200
300
400
454 a.a.

Protein Preferred Names

Protein Names

SH2 domain-containing protein 4A

protein SH(2)A

SH2D4A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SH2D4A	Q9H788	KRT40	Homo sapiens	Q6A162	Y2H Prey Pooling	32296183
Intra	SH2D4A	Q9H788	KRT40	Homo sapiens	Q6A162	Y2H Array	32296183
Intra	SH2D4A	Q9H788	NECAB2	Homo sapiens	Q7Z6G3-2	Y2H Prey Pooling	32296183
Intra	SH2D4A	Q9H788	NECAB2	Homo sapiens	Q7Z6G3-2	Y2H Array	32296183
Intra	SH2D4A	Q9H788	NECAB2	Homo sapiens	Q7Z6G3-2	Validated Y2H	25416956
Intra	SH2D4A	Q9H788	SH3GL1	Homo sapiens	Q6FGM0	Y2H Array	25416956
Intra	SH2D4A	Q9H788	NUTM1	Homo sapiens	Q86Y26	Y2H Prey Pooling	25416956
Intra	SH2D4A	Q9H788	NUTM1	Homo sapiens	Q86Y26	Y2H Array	25416956
Intra	SH2D4A	Q9H788	CADPS	Homo sapiens	A2RRN7	Y2H Prey Pooling	32296183
Intra	SH2D4A	Q9H788	CADPS	Homo sapiens	A2RRN7	Y2H Array	32296183
Intra	SH2D4A	Q9H788	ZNF774	Homo sapiens	Q6NX45	Y2H Prey Pooling	32296183
Intra	SH2D4A	Q9H788	ZNF774	Homo sapiens	Q6NX45	Y2H Array	32296183
Intra	SH2D4A	Q9H788	MAGEA6	Homo sapiens	P43360	Y2H Prey Pooling	25416956
Intra	SH2D4A	Q9H788	MAGEA6	Homo sapiens	P43360	Y2H Prey Pooling	32296183
Intra	SH2D4A	Q9H788	MAGEA6	Homo sapiens	P43360	Y2H Array	32296183
Intra	SH2D4A	Q9H788	PSTPIP1	Homo sapiens	O43586	Validated Y2H	25416956
Intra	SH2D4A	Q9H788	PSTPIP1	Homo sapiens	O43586	Y2H Array	25416956
Intra	SH2D4A	Q9H788	HOOK2	Homo sapiens	Q96ED9-2	Y2H Prey Pooling	32296183
Intra	SH2D4A	Q9H788	HOOK2	Homo sapiens	Q96ED9-2	Y2H Array	32296183
Intra	SH2D4A	Q9H788	GRAMD4	Homo sapiens	Q6IC98	Y2H Array	32296183
Intra	SH2D4A	Q9H788	GRAMD4	Homo sapiens	Q6IC98	Y2H Prey Pooling	32296183
Intra	SH2D4A	Q9H788	PDE4DIP	Homo sapiens	Q5VU43	Y2H Prey Pooling	25416956
Intra	SH2D4A	Q9H788	PDE4DIP	Homo sapiens	Q5VU43	Validated Y2H	25416956
Intra	SH2D4A	Q9H788	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	32296183
Intra	SH2D4A	Q9H788	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	31515488
Intra	SH2D4A	Q9H788	TFIP11	Homo sapiens	Q9UBB9	Y2H Prey Pooling	32296183
Intra	SH2D4A	Q9H788	TFIP11	Homo sapiens	Q9UBB9	Validated Y2H	32296183
Intra	SH2D4A	Q9H788	TRIML2	Homo sapiens	Q8N7C3	Y2H Prey Pooling	32296183
Intra	SH2D4A	Q9H788	TRIML2	Homo sapiens	Q8N7C3	Y2H Array	32296183
Intra	SH2D4A	Q9H788	CDR2L	Homo sapiens	Q86X02	Y2H Prey Pooling	32296183
Intra	SH2D4A	Q9H788	CDR2L	Homo sapiens	Q86X02	Y2H Array	32296183
Intra	SH2D4A	Q9H788	MTUS2	Homo sapiens	Q5JR59-3	Y2H Prey Pooling	32296183
Intra	SH2D4A	Q9H788	MTUS2	Homo sapiens	Q5JR59-3	Y2H Array	32296183
Intra	SH2D4A	Q9H788	CDR2	Homo sapiens	Q01850	Y2H Array	32296183
Intra	SH2D4A	Q9H788	CDR2	Homo sapiens	Q01850	Validated Y2H	25416956
Intra	SH2D4A	Q9H788	CDR2	Homo sapiens	Q01850	Y2H Prey Pooling	32296183
Intra	SH2D4A	Q9H788	FCHSD2	Homo sapiens	O94868-3	Y2H Prey Pooling	32296183
Intra	SH2D4A	Q9H788	FCHSD2	Homo sapiens	O94868-3	Y2H Array	32296183
Intra	SH2D4A	Q9H788	FCHO1	Homo sapiens	A0A0C3SFZ9	Y2H Array	32296183
Intra	SH2D4A	Q9H788	FCHO1	Homo sapiens	A0A0C3SFZ9	Y2H Prey Pooling	32296183
Intra	SH2D4A	Q9H788	CASK	Homo sapiens	O14936-4	Y2H Array	32296183
Intra	SH2D4A	Q9H788	CASK	Homo sapiens	O14936-4	Y2H Prey Pooling	32296183
Intra	SH2D4A	Q9H788	TACC1	Homo sapiens	O75410-7	Y2H Array	32296183
Intra	SH2D4A	Q9H788	TACC1	Homo sapiens	O75410-7	Y2H Prey Pooling	32296183
Intra	SH2D4A	Q9H788	ZMYND12	Homo sapiens	Q9H0C1	Y2H Prey Pooling	32296183
Intra	SH2D4A	Q9H788	ZMYND12	Homo sapiens	Q9H0C1	Y2H Array	32296183
Intra	SH2D4A	Q9H788	WWOX	Homo sapiens	Q9NZC7-5	Y2H Prey Pooling	32296183
Intra	SH2D4A	Q9H788	WWOX	Homo sapiens	Q9NZC7-5	Validated Y2H	32296183
Intra	SH2D4A	Q9H788	WWOX	Homo sapiens	Q9NZC7-5	Y2H Array	32296183
Intra	SH2D4A	Q9H788	CASK	Homo sapiens	O14936	Y2H Array	29892012
Intra	SH2D4A	Q9H788	CASK	Homo sapiens	O14936	Y2H Prey Pooling	25416956
Intra	SH2D4A	Q9H788	DBNL	Homo sapiens	Q9UJU6-2	Validated Y2H	32296183
Intra	SH2D4A	Q9H788	DBNL	Homo sapiens	Q9UJU6-2	Y2H Array	32296183
Intra	SH2D4A	Q9H788	DBNL	Homo sapiens	Q9UJU6-2	Y2H Prey Pooling	32296183
Intra	SH2D4A	Q9H788	MBD3L1	Homo sapiens	Q8WWY6	Y2H Prey Pooling	32296183
Intra	SH2D4A	Q9H788	MBD3L1	Homo sapiens	Q8WWY6	Y2H Array	32296183
Intra	SH2D4A	Q9H788	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	SH2D4A	Q9H788	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	SH2D4A	Q9H788	SKAP1	Homo sapiens	Q86WV1	Y2H Prey Pooling	25416956
Intra	SH2D4A	Q9H788	SKAP1	Homo sapiens	Q86WV1	Validated Y2H	25416956
Intra	SH2D4A	Q9H788	CCDC172	Homo sapiens	P0C7W6	Y2H Prey Pooling	25416956
Intra	SH2D4A	Q9H788	CCDC172	Homo sapiens	P0C7W6	Y2H Array	25416956
Intra	SH2D4A	Q9H788	HMBOX1	Homo sapiens	Q6NT76	Y2H Prey Pooling	32296183
Intra	SH2D4A	Q9H788	HMBOX1	Homo sapiens	Q6NT76	Y2H Array	32296183
Intra	SH2D4A	Q9H788	HMBOX1	Homo sapiens	Q6NT76	Y2H Prey Pooling	25416956
Intra	SH2D4A	Q9H788	VPS52	Homo sapiens	Q8N1B4	Y2H Array	25416956
Intra	SH2D4A	Q9H788	VPS52	Homo sapiens	Q8N1B4	Y2H Prey Pooling	25416956
Intra	SH2D4A	Q9H788	PRKAR1B	Homo sapiens	P31321	Y2H Array	32296183
Intra	SH2D4A	Q9H788	PRKAR1B	Homo sapiens	P31321	Y2H Prey Pooling	32296183
Intra	SH2D4A	Q9H788	PNMA1	Homo sapiens	Q8ND90	Y2H Prey Pooling	32296183
Intra	SH2D4A	Q9H788	PNMA1	Homo sapiens	Q8ND90	Y2H Array	32296183
Intra	SH2D4A	Q9H788	CCDC88B	Homo sapiens	A6NC98	Y2H Prey Pooling	32296183
Intra	SH2D4A	Q9H788	CCDC88B	Homo sapiens	A6NC98	Y2H Array	32296183
Intra	SH2D4A	Q9H788	PPP1CB	Homo sapiens	P62140	Validated Y2H	25416956
Intra	SH2D4A	Q9H788	PPP1CB	Homo sapiens	P62140	Y2H Prey Pooling	32296183
Intra	SH2D4A	Q9H788	PPP1CB	Homo sapiens	P62140	Y2H Prey Pooling	25416956
Intra	SH2D4A	Q9H788	PPP1CB	Homo sapiens	P62140	Y2H Array	25416956
Intra	SH2D4A	Q9H788	PPP1CB	Homo sapiens	P62140	Y2H Array	32296183
Intra	SH2D4A	Q9H788	PPP1CB	Homo sapiens	P62140	Anti Tag CoIP	33961781
Intra	SH2D4A	Q9H788	PPP1CB	Homo sapiens	P62140	Anti Tag CoIP	28514442
Intra	SH2D4A	Q9H788	PPP1CA	Homo sapiens	P62136	Anti Tag CoIP	28514442
Intra	SH2D4A	Q9H788	PPP1CA	Homo sapiens	P62136	Far-WB	19389623
Intra	SH2D4A	Q9H788	PPP1CA	Homo sapiens	P62136	Anti Tag CoIP	33961781
Intra	SH2D4A	Q9H788	STAM2	Homo sapiens	O75886	Validated Y2H	25416956
Intra	SH2D4A	Q9H788	ALAS1	Homo sapiens	P13196	Y2H Array	25416956
Intra	SH2D4A	Q9H788	ALAS1	Homo sapiens	P13196	Y2H Prey Pooling	25416956
Intra	SH2D4A	Q9H788	GRB2	Homo sapiens	P62993	Y2H Pooling	20936779
Intra	SH2D4A	Q9H788	GRB2	Homo sapiens	P62993	Y2H Prey Pooling	32296183
Intra	SH2D4A	Q9H788	GRB2	Homo sapiens	P62993	Y2H Array	32296183
Intra	SH2D4A	Q9H788	SPAG5	Homo sapiens	Q96R06	Validated Y2H	25416956
Intra	SH2D4A	Q9H788	BLOC1S2	Homo sapiens	Q6QNY1	Y2H Array	32296183
Intra	SH2D4A	Q9H788	BLOC1S2	Homo sapiens	Q6QNY1	Y2H Prey Pooling	32296183
Intra	SH2D4A	Q9H788	GPRASP2	Homo sapiens	Q96D09	Y2H Prey Pooling	32296183
Intra	SH2D4A	Q9H788	GPRASP2	Homo sapiens	Q96D09	Y2H Array	32296183
Intra	SH2D4A	Q9H788	FSD2	Homo sapiens	A1L4K1	Y2H Array	32296183
Intra	SH2D4A	Q9H788	FSD2	Homo sapiens	A1L4K1	Y2H Prey Pooling	25416956
Intra	SH2D4A	Q9H788	FSD2	Homo sapiens	A1L4K1	Y2H Prey Pooling	32296183
Intra	SH2D4A	Q9H788	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Array	32296183
Intra	SH2D4A	Q9H788	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Prey Pooling	32296183
Intra	SH2D4A	Q9H788	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	SH2D4A	Q9H788	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	25416956
Intra	SH2D4A	Q9H788	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	SH2D4A	Q9H788	GOLGA2	Homo sapiens	Q08379	Y2H Array	25416956
Intra	SH2D4A	Q9H788	ZNF655	Homo sapiens	Q8N720	Y2H Prey Pooling	32296183
Intra	SH2D4A	Q9H788	ZNF655	Homo sapiens	Q8N720	Y2H Array	32296183
Intra	SH2D4A	Q9H788	YPEL2	Homo sapiens	Q96QA6	Y2H Prey Pooling	32296183
Intra	SH2D4A	Q9H788	YPEL2	Homo sapiens	Q96QA6	Y2H Array	32296183
Intra	SH2D4A	Q9H788	SH3GL1	Homo sapiens	Q99961	Y2H Prey Pooling	32296183
Intra	SH2D4A	Q9H788	SH3GL1	Homo sapiens	Q99961	Y2H Array	19060904
Intra	SH2D4A	Q9H788	SH3GL1	Homo sapiens	Q99961	Y2H Pooling	19060904
Intra	SH2D4A	Q9H788	SH3GL1	Homo sapiens	Q99961	Y2H Array	32296183
Intra	SH2D4A	Q9H788	HSF2BP	Homo sapiens	O75031	Y2H Prey Pooling	32296183
Intra	SH2D4A	Q9H788	HSF2BP	Homo sapiens	O75031	Y2H Array	32296183
Intra	SH2D4A	Q9H788	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	25416956
Intra	SH2D4A	Q9H788	TRIM27	Homo sapiens	P14373	Validated Y2H	25416956
Intra	SH2D4A	Q9H788	NINL	Homo sapiens	Q9Y2I6	Y2H Array	25416956
Intra	SH2D4A	Q9H788	NINL	Homo sapiens	Q9Y2I6	Y2H Prey Pooling	25416956
Intra	SH2D4A	Q9H788	RINT1	Homo sapiens	Q6NUQ1	Validated Y2H	25416956
Intra	SH2D4A	Q9H788	RINT1	Homo sapiens	Q6NUQ1	Y2H Prey Pooling	32296183
Intra	SH2D4A	Q9H788	RINT1	Homo sapiens	Q6NUQ1	Y2H Array	32296183
Intra	SH2D4A	Q9H788	MAGEA11	Homo sapiens	P43364	Pull Down	16189514
Intra	SH2D4A	Q9H788	CEP70	Homo sapiens	Q8NHQ1	Y2H Prey Pooling	32296183
Intra	SH2D4A	Q9H788	TRIM23	Homo sapiens	P36406	Y2H Array	25416956
Intra	SH2D4A	Q9H788	GRAP2	Homo sapiens	O75791	Y2H Prey Pooling	32296183
Intra	SH2D4A	Q9H788	GRAP2	Homo sapiens	O75791	Y2H Array	32296183
Intra	SH2D4A	Q9H788	LDOC1	Homo sapiens	O95751	Y2H Array	31515488
Intra	SH2D4A	Q9H788	LDOC1	Homo sapiens	O95751	Y2H Prey Pooling	25416956
Intra	SH2D4A	Q9H788	LDOC1	Homo sapiens	O95751	Y2H Prey Pooling	32296183
Intra	SH2D4A	Q9H788	LDOC1	Homo sapiens	O95751	Y2H Array	32296183
Intra	SH2D4A	Q9H788	LZTS2	Homo sapiens	Q9BRK4	Validated Y2H	25416956
Intra	SH2D4A	Q9H788	SORBS3	Homo sapiens	O60504	Y2H Prey Pooling	32296183
Intra	SH2D4A	Q9H788	SORBS3	Homo sapiens	O60504	Y2H Array	32296183
Intra	SH2D4A	Q9H788	CFAP53	Homo sapiens	Q96M91	Y2H Array	32296183
Intra	SH2D4A	Q9H788	CFAP53	Homo sapiens	Q96M91	Y2H Prey Pooling	32296183
Intra	SH2D4A	Q9H788	IKZF1	Homo sapiens	Q13422	Y2H Array	25416956
Intra	SH2D4A	Q9H788	IKZF1	Homo sapiens	Q13422	Y2H Prey Pooling	25416956
Intra	SH2D4A	Q9H788	IKZF1	Homo sapiens	Q13422	Validated Y2H	25416956
Intra	SH2D4A	Q9H788	HCLS1	Homo sapiens	P14317	Y2H Prey Pooling	32296183
Intra	SH2D4A	Q9H788	HCLS1	Homo sapiens	P14317	Y2H Array	32296183
Intra	SH2D4A	Q9H788	HCLS1	Homo sapiens	P14317	Y2H Array	25416956
Intra	SH2D4A	Q9H788	HCLS1	Homo sapiens	P14317	Y2H Array	31515488
Intra	SH2D4A	Q9H788	ARC	Homo sapiens	Q7LC44	Y2H Array	32296183
Intra	SH2D4A	Q9H788	ARC	Homo sapiens	Q7LC44	Y2H Prey Pooling	32296183
Intra	SH2D4A	Q9H788	DBNL	Homo sapiens	Q9UJU6	Y2H Array	25416956
Intra	SH2D4A	Q9H788	DBNL	Homo sapiens	Q9UJU6	Y2H Array	19060904
Intra	SH2D4A	Q9H788	DBNL	Homo sapiens	Q9UJU6	Y2H Prey Pooling	25416956
Intra	SH2D4A	Q9H788	DBNL	Homo sapiens	Q9UJU6	Y2H Pooling	19060904
Intra	SH2D4A	Q9H788	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	SH2D4A	Q9H788	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	SH2D4A	Q9H788	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183
Intra	SH2D4A	Q9H788	TTC19	Homo sapiens	Q6DKK2	Y2H Prey Pooling	32296183
Intra	SH2D4A	Q9H788	TTC19	Homo sapiens	Q6DKK2	Y2H Array	32296183
Intra	SH2D4A	Q9H788	PLEKHG4	Homo sapiens	Q58EX7	Y2H Array	32296183
Intra	SH2D4A	Q9H788	PLEKHG4	Homo sapiens	Q58EX7	Y2H Prey Pooling	32296183
Intra	SH2D4A	Q9H788	MORN3	Homo sapiens	Q6PF18	Y2H Prey Pooling	32296183
Intra	SH2D4A	Q9H788	MORN3	Homo sapiens	Q6PF18	Y2H Array	32296183
Intra	SH2D4A	Q9H788	MRFAP1	Homo sapiens	Q9Y605	Validated Y2H	32296183
Intra	SH2D4A	Q9H788	MRFAP1	Homo sapiens	Q9Y605	Y2H Array	32296183
Intra	SH2D4A	Q9H788	MRFAP1	Homo sapiens	Q9Y605	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12825	SH2D4A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SH2D4A	VGNC	VGNC:46114
Macaca mulatta	SH2D4A	VGNC	VGNC:81568
Bos taurus	SH2D4A	VGNC	VGNC:34560
Mus musculus	SH2D4A	MGD	MGI:1919531
Rattus norvegicus	SH2D4A	RGD	RGD:1307991
Felis catus	SH2D4A	VGNC	VGNC:65095

Name
Email *

	Sorry, but the email address you supplied was invalid.