PDCD11 - programmed cell death 11 Gene

Homo sapiens

Also known as ALG4; NFBP; RRP5; ALG-4

Gene ID: 22984 | Gene type: protein coding

About PDCD11

Cytogenetic location: 10q24.33 Genomic coordinates (GRCh38): 10:103,396,626-103,446,294 (from NCBI)

This gene has 7 transcripts (splice variants) and 204 orthologues. Ubiquitous expression in testis (RPKM 12.3), skin (RPKM 7.7) and 25 other tissues.

Summary

PDCD11 is a NF-kappa-B (NFKB1; 164011)-binding protein that colocalizes with U3 RNA (MIM 180710) in the nucleolus and is required for rRNA maturation and generation of 18S rRNA (Sweet et al., 2003 [PubMed 14624448]; Sweet et al., 2008 [PubMed 17654514]).[supplied by OMIM, Oct 2008]

PDCD11 Products(2)

mRNA	Protein	Name
NM_001411058.1	NP_001397987.1	protein RRP5 homolog isoform 1
NM_014976.2	NP_055791.1	protein RRP5 homolog isoform 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables NF-kappaB binding	IPI IPI: Inferred from physical interaction	14624448	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14624448	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	14624448	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDCD11 Protein Structure

Suf

0
300
600
900
1200
1500
1871 a.a.

Protein Preferred Names

Protein Names

protein RRP5 homolog

NF-kappa-B-binding protein

Related Diseases

Diseases

Alias

Dentin Caries

Compound Dental Caries	Dental Caries Extending Into Dentine
Dental Caries Extending Into Dentin

Enamel Caries

Primary Dental Caries	Dental Caries Limited To Enamel
Simple Dental Cavity

Epididymo-Orchitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10189	PDCD11 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PDCD11	MGD	MGI:1341788
Macaca mulatta	PDCD11	VGNC	VGNC:75596
Bos taurus	PDCD11	VGNC	VGNC:32659
Canis familiaris	PDCD11	VGNC	VGNC:44335
Rattus norvegicus	PDCD11	RGD	RGD:1304933
Felis catus	PDCD11	VGNC	VGNC:64077

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