WDFY3 - WD repeat and FYVE domain containing 3 Gene

Homo sapiens

Also known as ALFY; BCHS; MCPH18; ZFYVE25

Gene ID: 23001 | Gene type: protein coding

About WDFY3

Cytogenetic location: 4q21.23 Genomic coordinates (GRCh38): 4:84,669,597-84,966,690 (from NCBI)

This gene has 12 transcripts (splice variants), 231 orthologues, 7 paralogues and is associated with 3 phenotypes. Ubiquitous expression in kidney (RPKM 8.6), brain (RPKM 8.1) and 25 other tissues.

Summary

This gene encodes a phosphatidylinositol 3-phosphate-binding protein that functions as a master conductor for aggregate clearance by Autophagy. This protein shuttles from the nuclear membrane to colocalize with aggregated proteins, where it complexes with Other autophagic components to achieve macroautophagy-mediated clearance of these aggregated proteins. However, it is not necessary for starvation-induced macroautophagy. [provided by RefSeq, May 2010]

WDFY3 Products(1)

mRNA	Protein	Name
NM_014991.6	NP_055806.2	WD repeat and FYVE domain-containing protein 3

WDFY3 Protein Structure

PH_BEACH

Beach

WD40

FYVE

0
600
1200
1800
2400
3000
3526 a.a.

Protein Preferred Names

Protein Names

WD repeat and FYVE domain-containing protein 3

autophagy-linked FYVE protein

WDFY3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	WDFY3	Q8IZQ1	GABARAP	Homo sapiens	Q6IAW1	X-Ray Diffraction	24668264
Intra	WDFY3	Q8IZQ1	GABARAP	Homo sapiens	Q6IAW1	IF	24668264
Intra	WDFY3	Q8IZQ1	GABARAP	Homo sapiens	Q6IAW1	Pull Down	24668264
Intra	WDFY3	Q8IZQ1	GABARAP	Homo sapiens	Q6IAW1	Anti Tag CoIP	24668264
Intra	WDFY3	Q8IZQ1	GABARAP	Homo sapiens	Q6IAW1	ITC	24668264
Intra	WDFY3	Q8IZQ1	ATG5	Homo sapiens	Q9H1Y0	Anti Bait CoIP	20417604
Intra	WDFY3	Q8IZQ1	ATG5	Homo sapiens	Q9H1Y0	Pull Down	20417604
Intra	WDFY3	Q8IZQ1	ATG5	Homo sapiens	Q9H1Y0	Confocal	20417604
Intra	WDFY3	Q8IZQ1	MAP1LC3C	Homo sapiens	Q9BXW4	Pull Down	24668264
Intra	WDFY3	Q8IZQ1	MAP1LC3C	Homo sapiens	Q9BXW4	Anti Tag CoIP	24668264
Intra	WDFY3	Q8IZQ1	SQSTM1	Homo sapiens	Q13501	Pull Down	20168092
Intra	WDFY3	Q8IZQ1	SQSTM1	Homo sapiens	Q13501	Confocal	20168092
Intra	WDFY3	Q8IZQ1	SQSTM1	Homo sapiens	Q13501	Anti Bait CoIP	20417604
Intra	WDFY3	Q8IZQ1	SQSTM1	Homo sapiens	Q13501	Anti Bait CoIP	20168092
Intra	WDFY3	Q8IZQ1	SQSTM1	Homo sapiens	Q13501	Anti Tag CoIP	20168092
Intra	WDFY3	Q8IZQ1	MAP1LC3B	Homo sapiens	Q9GZQ8	IF	24668264
Intra	WDFY3	Q8IZQ1	MAP1LC3B	Homo sapiens	Q9GZQ8	Anti Bait CoIP	20417604
Intra	WDFY3	Q8IZQ1	HTT	Homo sapiens	P42858	Confocal	20417604
Intra	WDFY3	Q8IZQ1	HTT	Homo sapiens	P42858	Anti Bait CoIP	20417604
Intra	WDFY3	Q8IZQ1	GABARAPL1	Homo sapiens	Q9H0R8	ITC	24668264
Intra	WDFY3	Q8IZQ1	GABARAPL1	Homo sapiens	Q9H0R8	Pull Down	24668264
Intra	WDFY3	Q8IZQ1	GABARAPL1	Homo sapiens	Q9H0R8	Anti Tag CoIP	24668264
Cross	WDFY3	Q8IZQ1	tax	Human T-cell leukemia virus 1	P14079	Y2H Array	22458338

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Microcephaly 18, Primary, Autosomal Dominant

MCPH18

Primary Autosomal Dominant Microcephaly 18

Non-Specific Syndromic Intellectual Disability

Complex Neurodevelopmental Disorder

Esophageal Atresia

Tracheoesophageal Fistula	Congenital Atresia Of Esophagus
Congenital Imperforate Esophagus	Imperforate Esophagus
Oesophageal Atresia	Te Fistula
Tef	Tracheoesophageal Fistula With Or Without Esophageal Atresia

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Myopathy, Centronuclear, 2

Myopathy, Centronuclear, Autosomal Recessive	Autosomal Recessive Centronuclear Myopathy
CNM2	Centronuclear Myopathy 2
Ar-Cnm	Myotubular Myopathy, Autosomal Recessive
Autosomal Recessive Myotubular Myopathy	Centronuclear Myopathy Autosomal Recessive
Myopathy, Centronuclear, Type 2

Microcephaly 19, Primary, Autosomal Recessive

MCPH19	Primary Autosomal Recessive Microcephaly 19
Microcephaly, Type 19, Primary, Autosomal Recessive

Microcephaly, Autosomal Dominant

Autosomal Dominant Microcephaly	Microcephaly Autosomal Dominant
Autosomal Dominant Primary Microcephaly	Microcephaly With Autosomal Dominant Inheritance

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Primary Autosomal Recessive Microcephaly

Autosomal Recessive Primary Microcephaly	Mcph
True Microcephaly	Microcephalia Vera
Microcephaly Vera	Microcephaly Primary Hereditary
Microcephaly, Primary, Autosomal Recessive	Primary Microcephaly

Paget'S Disease Of Bone

Osteitis Deformans	Paget Disease Of Bone
Osseous Paget'S Disease	Paget Disease Of Bone, Familial
Bone Paget Disease	Familial Paget'S Disease Of Bone
Paget'S Bone Disease	Familial Paget Disease Of Bone
Paget Disease, Bone	Pdb
Pagets Bone Disease

Primary Microcephaly

True Microcephaly

Microcephaly, Primary

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15756	WDFY3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	WDFY3	MGD	MGI:1096875
Bos taurus	WDFY3	VGNC	VGNC:36877
Felis catus	WDFY3	VGNC	VGNC:67011
Canis familiaris	WDFY3	VGNC	VGNC:48346
Rattus norvegicus	WDFY3	RGD	RGD:1307097
Macaca mulatta	WDFY3	VGNC	VGNC:79279

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