KLHDC10 - kelch domain containing 10 Gene

Homo sapiens

Also known as slim; PNAS-138

Gene ID: 23008 | Gene type: protein coding

About KLHDC10

Cytogenetic location: 7q32.2 Genomic coordinates (GRCh38): 7:130,070,534-130,135,705 (from NCBI)

This gene has 4 transcripts (splice variants), 266 orthologues and 10 paralogues. Ubiquitous expression in testis (RPKM 13.1), thyroid (RPKM 12.0) and 25 other tissues.

Summary

Enables ubiquitin ligase-substrate adaptor activity. Involved in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Located in nucleoplasm. Is active in Cul2-RING ubiquitin Ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

KLHDC10 Products(1)

mRNA	Protein	Name
NM_014997.4	NP_055812.1	kelch domain-containing protein 10

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20562859	GOA
enables ubiquitin-like ligase-substrate adaptor activity	IDA IDA: Inferred from direct assay	29779948	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in rescue of stalled ribosome	IDA IDA: Inferred from direct assay	33909987	GOA
involved in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway	IDA IDA: Inferred from direct assay	29779948	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Cul2-RING ubiquitin ligase complex	IDA IDA: Inferred from direct assay	29779948	GOA
is active in cytoplasm	IDA IDA: Inferred from direct assay	23102700	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KLHDC10 Protein Structure

Kelch_6

Kelch_4

Kelch_1

Kelch_4

0
100
200
300
400
442 a.a.

Protein Preferred Names

Protein Names

kelch domain-containing protein 10

PNAS-119

KLHDC10 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	KLHDC10	Q6PID8	NUDCD3	Homo sapiens	Q8IVD9	Anti Tag CoIP	20562859

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Postpoliomyelitis Syndrome

Postpolio Syndrome	Post-Polio Syndrome
Post Polio Syndrome	Polio Late Effects
Post-Polio Muscular Atrophy	Post-Polio Sequelae
Post-Poliomyelitic Syndrome	Postpolio Sequelae
Postpoliomyelitic Syndrome	Postpoliomyelitis Sequelae

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07347	KLHDC10 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	KLHDC10	VGNC	VGNC:30634
Macaca mulatta	KLHDC10	VGNC	VGNC:74102
Mus musculus	KLHDC10	MGD	MGI:1924038
Rattus norvegicus	KLHDC10	RGD	RGD:1309792
Felis catus	KLHDC10	VGNC	VGNC:63135
Canis familiaris	KLHDC10	VGNC	VGNC:42440

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