2. Gene
  3. FOXD2 - forkhead box D2 Gene

FOXD2 - forkhead box D2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as FKHL17; FREAC9; FREAC-9

Gene ID: 2306 | Gene type: protein coding

About FOXD2

Cytogenetic location: 1p33 Genomic coordinates (GRCh38): 1:47,438,044-47,440,691 (from NCBI)

This gene has 1 transcript (splice variant), 128 orthologues and 42 paralogues.

Summary

This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined. [provided by RefSeq, Jul 2008]

FOXD2 Products(1)

mRNA Protein Name
NM_004474.4 NP_004465.3 forkhead box protein D2
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
12621056 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
23332764 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12621056 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FOXD2 Protein Structure

Forkhead

Forkhead: Forkhead domain (127 - 222)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 495 a.a.
Protein Preferred Names Protein Names

forkhead box protein D2

forkhead, drosophila, homolog-like 17

FOXD2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra FOXD2 O60548 CADPS Homo sapiens A2RRN7
Y2H Array
32296183
Intra FOXD2 O60548 CADPS Homo sapiens A2RRN7
Y2H Prey Pooling
32296183
Intra FOXD2 O60548 KRTAP19-7 Homo sapiens Q3SYF9
Y2H Array
32296183
Intra FOXD2 O60548 KRTAP19-7 Homo sapiens Q3SYF9
Validated Y2H
32296183
Intra FOXD2 O60548 KRTAP19-7 Homo sapiens Q3SYF9
Y2H Prey Pooling
32296183
Intra FOXD2 O60548 KRTAP8-1 Homo sapiens Q8IUC2
Y2H Prey Pooling
32296183
Intra FOXD2 O60548 KRTAP8-1 Homo sapiens Q8IUC2
Validated Y2H
32296183
Intra FOXD2 O60548 KRTAP8-1 Homo sapiens Q8IUC2
Y2H Array
32296183
Intra FOXD2 O60548 TLE5 Homo sapiens Q08117-2
Y2H Prey Pooling
32296183
Intra FOXD2 O60548 TLE5 Homo sapiens Q08117-2
Validated Y2H
32296183
Intra FOXD2 O60548 TLE5 Homo sapiens Q08117-2
Y2H Array
32296183
Intra FOXD2 O60548 KRTAP6-2 Homo sapiens Q3LI66
Y2H Prey Pooling
32296183
Intra FOXD2 O60548 KRTAP6-2 Homo sapiens Q3LI66
Validated Y2H
32296183
Intra FOXD2 O60548 KRTAP6-2 Homo sapiens Q3LI66
Y2H Array
32296183
Intra FOXD2 O60548 KRTAP15-1 Homo sapiens Q3LI76
Y2H Array
32296183
Intra FOXD2 O60548 KRTAP15-1 Homo sapiens Q3LI76
Y2H Prey Pooling
32296183
Intra FOXD2 O60548 KRTAP15-1 Homo sapiens Q3LI76
Validated Y2H
32296183
Intra FOXD2 O60548 KRTAP19-2 Homo sapiens Q3LHN2
Y2H Prey Pooling
32296183
Intra FOXD2 O60548 KRTAP19-2 Homo sapiens Q3LHN2
Validated Y2H
32296183
Intra FOXD2 O60548 KRTAP19-2 Homo sapiens Q3LHN2
Y2H Array
32296183
Intra FOXD2 O60548 NOTO Homo sapiens A8MTQ0
Y2H Prey Pooling
32296183
Intra FOXD2 O60548 NOTO Homo sapiens A8MTQ0
Y2H Array
32296183
Intra FOXD2 O60548 FOXH1 Homo sapiens O75593
Y2H Array
32296183
Intra FOXD2 O60548 FOXH1 Homo sapiens O75593
Validated Y2H
32296183
Intra FOXD2 O60548 FOXH1 Homo sapiens O75593
Y2H Prey Pooling
32296183
Intra FOXD2 O60548 KRTAP21-2 Homo sapiens Q3LI59
Y2H Prey Pooling
32296183
Intra FOXD2 O60548 KRTAP21-2 Homo sapiens Q3LI59
Validated Y2H
32296183
Intra FOXD2 O60548 KRTAP21-2 Homo sapiens Q3LI59
Y2H Array
32296183
Intra FOXD2 O60548 KRTAP6-3 Homo sapiens Q3LI67
Y2H Array
32296183
Intra FOXD2 O60548 KRTAP6-3 Homo sapiens Q3LI67
Y2H Prey Pooling
32296183
Intra FOXD2 O60548 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra FOXD2 O60548 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra FOXD2 O60548 MAGED1 Homo sapiens Q9Y5V3
Y2H Prey Pooling
32296183
Intra FOXD2 O60548 MAGED1 Homo sapiens Q9Y5V3
Validated Y2H
32296183
Intra FOXD2 O60548 MAGED1 Homo sapiens Q9Y5V3
Y2H Array
32296183
Intra FOXD2 O60548 SPMIP9 Homo sapiens Q96LM6
Y2H Prey Pooling
32296183
Intra FOXD2 O60548 SPMIP9 Homo sapiens Q96LM6
Validated Y2H
32296183
Intra FOXD2 O60548 SPMIP9 Homo sapiens Q96LM6
Y2H Array
32296183
Intra FOXD2 O60548 KRTAP3-2 Homo sapiens Q9BYR7
Validated Y2H
32296183
Intra FOXD2 O60548 KRTAP3-2 Homo sapiens Q9BYR7
Y2H Array
32296183
Intra FOXD2 O60548 KRTAP3-2 Homo sapiens Q9BYR7
Y2H Prey Pooling
32296183
Intra FOXD2 O60548 POU2AF1 Homo sapiens Q16633
Validated Y2H
32296183
Intra FOXD2 O60548 POU2AF1 Homo sapiens Q16633
Y2H Array
32296183
Intra FOXD2 O60548 POU2AF1 Homo sapiens Q16633
Y2H Prey Pooling
32296183
Intra FOXD2 O60548 ARID5A Homo sapiens Q03989
Y2H Array
32296183
Intra FOXD2 O60548 ARID5A Homo sapiens Q03989
Y2H Prey Pooling
32296183
Intra FOXD2 O60548 ARID5A Homo sapiens Q03989
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Thyroid Gland Mucoepidermoid Carcinoma

Mucoepidermoid Thyroid Carcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05044 FOXD2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus FOXD2 VGNC VGNC:107543
Macaca mulatta FOXD2 VGNC VGNC:72695
Mus musculus FOXD2 MGD MGI:1347471
Bos taurus FOXD2 VGNC VGNC:55192
Rattus norvegicus FOXD2 RGD RGD:1304642