MAGED1 - MAGE family member D1 Gene

Homo sapiens

Also known as NRAGE; DLXIN-1

Gene ID: 9500 | Gene type: protein coding

About MAGED1

Cytogenetic location: Xp11.22 Genomic coordinates (GRCh38): X:51,803,076-51,902,354 (from NCBI)

This gene has 10 transcripts (splice variants), 177 orthologues and 37 paralogues. Ubiquitous expression in brain (RPKM 56.4), placenta (RPKM 55.0) and 25 other tissues.

Summary

This gene is a member of the melanoma antigen gene (MAGE) family. Most of the genes of this family encode tumor specific antigens that are not expressed in normal adult tissues except testis. Although the protein encoded by this gene shares strong homology with members of the MAGE family, it is expressed in almost all normal adult tissues. This gene has been demonstrated to be involved in the p75 neurotrophin receptor mediated programmed cell death pathway. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

MAGED1 Products(3)

mRNA	Protein	Name
NM_001005332.2	NP_001005332.1	melanoma-associated antigen D1 isoform b
NM_001005333.2	NP_001005333.1	melanoma-associated antigen D1 isoform a
NM_006986.4	NP_008917.3	melanoma-associated antigen D1 isoform b

MAGED1 Protein Structure

MAGE

0
200
400
600
778 a.a.

Protein Preferred Names

Protein Names

melanoma-associated antigen D1

MAGE tumor antigen CCF

Related Diseases

Diseases

Alias

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Schaaf-Yang Syndrome

Prader-Willi-Like Syndrome	Chitayat-Hall Syndrome
SHFYNG	Pwls
Magel2-Related Prader-Willi-Like Syndrome	Magel2-Related Pwls
Arthrogryposis, Distal, With Hypopituitarism, Mental Retardation, And Facial Anomalies	Distal Arthrogryposis With Hypopituitarism, Intellectual Disability And Facial A
Distal Arthrogryposis With Hypopituitarism, Intellectual Disability And Facial Anomalies	Pws Due To A Point Mutation
Pws Due To Point Mutation	Prader-Willi Syndrome Due To A Point Mutation
Prader-Willi Syndrome Due To Point Mutation	Pws-Like

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07976	MAGED1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MAGED1	MGD	MGI:1930187
Canis familiaris	MAGED1	VGNC	VGNC:42924
Bos taurus	MAGED1	VGNC	VGNC:55062
Rattus norvegicus	MAGED1	RGD	RGD:70898
Macaca mulatta	MAGED1	VGNC	VGNC:74479

Name
Email *

	Sorry, but the email address you supplied was invalid.