WAPL - WAPL cohesin release factor Gene

Homo sapiens

Also known as FOE; WAPAL; KIAA0261

Gene ID: 23063 | Gene type: protein coding

About WAPL

Cytogenetic location: 10q23.2 Genomic coordinates (GRCh38): 10:86,435,256-86,521,792 (from NCBI)

This gene has 4 transcripts (splice variants) and 295 orthologues. Ubiquitous expression in testis (RPKM 17.0), lymph node (RPKM 9.9) and 25 other tissues.

Summary

Involved in several processes, including negative regulation of DNA replication; negative regulation of chromatin binding activity; and regulation of sister chromatid cohesion. Located in several cellular components, including Golgi apparatus; intercellular bridge; and microtubule Cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022]

WAPL Products(2)

mRNA	Protein	Name
NM_001318328.2	NP_001305257.1	wings apart-like protein homolog isoform 2
NM_015045.5	NP_055860.1	wings apart-like protein homolog isoform 1

WAPL Protein Structure

WAPL

0
200
400
600
800
1000
1190 a.a.

Protein Preferred Names

Protein Names

wings apart-like protein homolog

friend of EBNA2 (Epstein-Barr virus nuclear protein 2)

Related Diseases

Diseases

Alias

Cornelia De Lange Syndrome

De Lange Syndrome	Brachmann De Lange Syndrome
Brachmann-De Lange Syndrome	Cdls
Bdls	Typus Degenerativus Amstelodamensis

Roberts-Sc Phocomelia Syndrome

Roberts Syndrome	Sc Phocomelia Syndrome
RBS	Long Bone Deficiencies Associated With Cleft Lip-Palate
Sc Pseudothalidomide Syndrome	Appelt-Gerken-Lenz Syndrome
Pseudothalidomide Syndrome	Tetraphocomelia-Cleft Palate Syndrome
Hypomelia Hypotrichosis Facial Hemangioma Syndrome	Roberts Syndrome/Sc Phocomelia
Roberts Tetraphocomelia Syndrome	Sc Syndrome
Sc Phocomelia	Sc Disease
Sc	Hemoglobin Sc Disease

Warsaw Breakage Syndrome

WABS

WBRS

Chronic Atrial And Intestinal Dysrhythmia

CAID	Caid Syndrome
Cohesinopathy Affecting Heart And Gut Rhythm	Chronic Atrial Intestinal Dysrhythmia Syndrome
Chronic Atrial And Intestinal Dysrhythmia Syndrome	Chronic Atrial Dysrhythmia-Intestinal Motility Disorder
Dysrhythmia, Atrial And Intestinal, Chronic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15738	WAPL Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	WAPL	VGNC	VGNC:36862
Rattus norvegicus	WAPL	RGD	RGD:1590924
Macaca mulatta	WAPL	VGNC	VGNC:79384
Mus musculus	WAPL	MGD	MGI:2675859
Canis familiaris	WAPL	VGNC	VGNC:48330
Felis catus	WAPL	VGNC	VGNC:66998

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