2. Gene
  3. WAPL - WAPL cohesin release factor Gene

WAPL - WAPL cohesin release factor Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as FOE; WAPAL; KIAA0261

Gene ID: 23063 | Gene type: protein coding

About WAPL

Cytogenetic location: 10q23.2 Genomic coordinates (GRCh38): 10:86,435,256-86,521,792 (from NCBI)

This gene has 4 transcripts (splice variants) and 295 orthologues. Ubiquitous expression in testis (RPKM 17.0), lymph node (RPKM 9.9) and 25 other tissues.

Summary

Involved in several processes, including negative regulation of DNA replication; negative regulation of chromatin binding activity; and regulation of sister chromatid cohesion. Located in several cellular components, including Golgi apparatus; intercellular bridge; and microtubule Cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022]

WAPL Products(2)

mRNA Protein Name
NM_001318328.2 NP_001305257.1 wings apart-like protein homolog isoform 2
NM_015045.5 NP_055860.1 wings apart-like protein homolog isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables ATP-dependent protein-DNA unloader activity IMP
IMP: Inferred from mutant phenotype
17113138 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17112726 GOA
Biological Process GO Annotation Evidence Reference Source
involved in mitotic sister chromatid segregation IMP
IMP: Inferred from mutant phenotype
17113138 GOA
involved in negative regulation of DNA replication IMP
IMP: Inferred from mutant phenotype
19907496 GOA
involved in negative regulation of chromatin binding IMP
IMP: Inferred from mutant phenotype
17113138 GOA
involved in negative regulation of sister chromatid cohesion IMP
IMP: Inferred from mutant phenotype
19696148 GOA
involved in protein localization to chromatin IMP
IMP: Inferred from mutant phenotype
21111234 GOA
Cellular Component GO Annotation Evidence Reference Source
located in chromatin IDA
IDA: Inferred from direct assay
17113138 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
17113138 GOA
located in nucleus IDA
IDA: Inferred from direct assay
17113138 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WAPL Protein Structure

WAPL

WAPL: Wings apart-like protein regulation of heterochromatin (636 - 999)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1190 a.a.
Protein Preferred Names Protein Names

wings apart-like protein homolog

friend of EBNA2 (Epstein-Barr virus nuclear protein 2)

WAPL Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
WAPL Q7Z5K2 STAG2 Homo sapiens Q8N3U4
Pull Down
25173175
Intra
WAPL Q7Z5K2 STAG2 Homo sapiens Q8N3U4
TAP
20360068
Intra
WAPL Q7Z5K2 STAG2 Homo sapiens Q8N3U4
Anti Bait CoIP
17113138
Intra
WAPL Q7Z5K2 STAG2 Homo sapiens Q8N3U4
Anti Bait CoIP
17112726
Intra
WAPL Q7Z5K2 PDS5B Homo sapiens Q9NTI5
Anti Bait CoIP
17113138
Intra
WAPL Q7Z5K2 PDS5B Homo sapiens Q9NTI5
Anti Bait CoIP
17112726
Intra
WAPL Q7Z5K2 PDS5B Homo sapiens Q9NTI5
TAP
20360068
Intra
WAPL Q7Z5K2 PDS5B Homo sapiens Q9NTI5
Cosedimentation
17113138
Intra
WAPL Q7Z5K2 RAD21 Homo sapiens O60216
Anti Bait CoIP
17113138
Intra
WAPL Q7Z5K2 RAD21 Homo sapiens O60216
Anti Bait CoIP
17112726
Intra
WAPL Q7Z5K2 RAD21 Homo sapiens O60216
Anti Tag CoIP
26496610
Intra
WAPL Q7Z5K2 RAD21 Homo sapiens O60216
Anti Tag CoIP
35271311
Intra
WAPL Q7Z5K2 RAD21 Homo sapiens O60216
TAP
20360068
Intra
WAPL Q7Z5K2 RAD21 Homo sapiens O60216
Pull Down
25173175
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Cornelia De Lange Syndrome

De Lange Syndrome

Brachmann De Lange Syndrome

Brachmann-De Lange Syndrome

Cdls

Bdls

Typus Degenerativus Amstelodamensis
Roberts-Sc Phocomelia Syndrome

Roberts Syndrome

Sc Phocomelia Syndrome

RBS

Long Bone Deficiencies Associated With Cleft Lip-Palate

Sc Pseudothalidomide Syndrome

Appelt-Gerken-Lenz Syndrome

Pseudothalidomide Syndrome

Tetraphocomelia-Cleft Palate Syndrome

Hypomelia Hypotrichosis Facial Hemangioma Syndrome

Roberts Syndrome/Sc Phocomelia

Roberts Tetraphocomelia Syndrome

Sc Syndrome

Sc Phocomelia

Sc Disease

Sc

Hemoglobin Sc Disease
Warsaw Breakage Syndrome

WABS

WBRS
Chronic Atrial And Intestinal Dysrhythmia

CAID

Caid Syndrome

Cohesinopathy Affecting Heart And Gut Rhythm

Chronic Atrial Intestinal Dysrhythmia Syndrome

Chronic Atrial And Intestinal Dysrhythmia Syndrome

Chronic Atrial Dysrhythmia-Intestinal Motility Disorder

Dysrhythmia, Atrial And Intestinal, Chronic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15738 WAPL Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus WAPL VGNC VGNC:36862
Rattus norvegicus WAPL RGD RGD:1590924
Macaca mulatta WAPL VGNC VGNC:79384
Mus musculus WAPL MGD MGI:2675859
Canis familiaris WAPL VGNC VGNC:48330
Felis catus WAPL VGNC VGNC:66998