CAND2 - cullin associated and neddylation dissociated 2 (putative) Gene

Homo sapiens

Also known as Tp120b; TIP120B

Gene ID: 23066 | Gene type: protein coding

About CAND2

Cytogenetic location: 3p25.2 Genomic coordinates (GRCh38): 3:12,796,680-12,834,803 (from NCBI)

This gene has 6 transcripts (splice variants), 191 orthologues and 1 paralogue. Broad expression in heart (RPKM 9.1), testis (RPKM 8.9) and 16 other tissues.

Summary

Predicted to enable TBP-class protein binding activity. Predicted to be involved in SCF complex assembly; positive regulation of transcription, DNA-templated; and protein ubiquitination. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

CAND2 Products(2)

mRNA	Protein	Name
NM_001162499.2	NP_001155971.1	cullin-associated NEDD8-dissociated protein 2 isoform 1
NM_012298.3	NP_036430.1	cullin-associated NEDD8-dissociated protein 2 isoform 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12207886	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	12692129	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CAND2 Protein Structure

HEAT_EZ

TIP120

0
200
400
600
800
1000
1236 a.a.

Protein Preferred Names

Protein Names

cullin-associated NEDD8-dissociated protein 2

TBP interacting protein

CAND2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CAND2	O75155	FHL2	Homo sapiens	Q14192	Validated Y2H	32296183
Intra	CAND2	O75155	CIDEB	Homo sapiens	Q9UHD4	Y2H Prey Pooling	32296183
Intra	CAND2	O75155	CIDEB	Homo sapiens	Q9UHD4	Validated Y2H	32296183
Intra	CAND2	O75155	CIDEB	Homo sapiens	Q9UHD4	Y2H Array	32296183
Intra	CAND2	O75155	SYP	Homo sapiens	P08247	Validated Y2H	32296183
Intra	CAND2	O75155	SYP	Homo sapiens	P08247	Y2H Array	32296183
Intra	CAND2	O75155	SYP	Homo sapiens	P08247	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Clubfoot

Congenital Talipes Equinovarus	Congenital Clubfoot
Congenital Equinovarus	Equinovarus Deformity Of Foot
Club Foot

Prostatic Adenoma

Prostatic Hyperplasia	Adenoma - Prostate
Adenoma Of Prostate	Benign Adenoma Of Prostate
Prostate Adenoma	Benign Prostatic Hyperplasia

Male Reproductive Organ Benign Neoplasm

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01877	CAND2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CAND2	RGD	RGD:620480
Macaca mulatta	CAND2	VGNC	VGNC:84220
Canis familiaris	CAND2	VGNC	VGNC:54586
Felis catus	CAND2	VGNC	VGNC:102018
Mus musculus	CAND2	MGD	MGI:1914338

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