Zc3h12a - zinc finger CCCH type containing 12A Gene

Mus musculus

Also known as Reg1; MCPIP; Mcpip1; MCPIP-1

Gene ID: 230738 | Gene type: protein coding

About Zc3h12a

Summary

Enables RNA binding activity; ribonuclease activity; and ribosome binding activity. Involved in several processes, including cellular response to cytokine stimulus; negative regulation of gene expression; and negative regulation of intracellular signal transduction. Located in nucleus and rough endoplasmic reticulum. Is extrinsic component of endoplasmic reticulum membrane. Used to study primary biliary cholangitis. Human ortholog(s) of this gene implicated in hepatitis B. Orthologous to human ZC3H12A (zinc finger CCCH-type containing 12A). [provided by Alliance of Genome Resources, Apr 2022]

Zc3h12a Products(1)

mRNA	Protein	Name
NM_153159.2	NP_694799.1	endoribonuclease ZC3H12A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA endonuclease activity	IDA IDA: Inferred from direct assay	22055188	MGI
enables RNA exonuclease activity	IDA IDA: Inferred from direct assay	19322177	MGI
enables RNA stem-loop binding	IDA IDA: Inferred from direct assay	23185455	MGI
enables mRNA 3'-UTR AU-rich region binding	IDA IDA: Inferred from direct assay	19322177	MGI
enables mRNA 3'-UTR binding	IDA IDA: Inferred from direct assay	23185455	MGI
enables mRNA binding	EXP EXP: Inferred from Experiment	26927947	MGI
enables nuclease activity	IMP IMP: Inferred from mutant phenotype	25282160	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	22037600	MGI
enables ribosome binding	IDA IDA: Inferred from direct assay	26255671	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in 3'-UTR-mediated mRNA destabilization	IDA IDA: Inferred from direct assay	19322177	MGI
involved in T cell receptor signaling pathway	IDA IDA: Inferred from direct assay	23185455	MGI
involved in T cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	25282160	MGI
involved in cellular response to chemokine	IDA IDA: Inferred from direct assay	19666473	MGI
involved in cellular response to glucose starvation	IDA IDA: Inferred from direct assay	21971051	MGI
involved in cellular response to ionomycin	IDA IDA: Inferred from direct assay	23185455	MGI
involved in cellular response to lipopolysaccharide	IDA IDA: Inferred from direct assay	19322177	MGI
involved in cellular response to oxidative stress	IDA IDA: Inferred from direct assay	21971051	MGI
involved in cellular response to sodium arsenite	IDA IDA: Inferred from direct assay	21971051	MGI
involved in mRNA catabolic process	IDA IDA: Inferred from direct assay	26000482	MGI
involved in negative regulation of T-helper 17 cell differentiation	IMP IMP: Inferred from mutant phenotype	25282160	MGI
involved in negative regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	21616078	MGI
involved in negative regulation of cardiac muscle contraction	IDA IDA: Inferred from direct assay	21616078	MGI
involved in negative regulation of cytokine production involved in inflammatory response	IDA IDA: Inferred from direct assay	21616078	MGI
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	18178554	MGI
involved in negative regulation of interleukin-1 beta production	IDA IDA: Inferred from direct assay	21616078	MGI
involved in negative regulation of interleukin-6 production	IDA IDA: Inferred from direct assay	21616078	MGI
involved in negative regulation of muscle cell apoptotic process	IDA IDA: Inferred from direct assay	21616078	MGI
involved in negative regulation of nitric oxide biosynthetic process	IDA IDA: Inferred from direct assay	21616078	MGI
involved in negative regulation of non-canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	21616078	MGI
involved in negative regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	21971051	MGI
involved in negative regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	21616078	MGI
involved in negative regulation of type II interferon production	IDA IDA: Inferred from direct assay	21616078	MGI
involved in positive regulation of autophagy	IMP IMP: Inferred from mutant phenotype	22739135	MGI
involved in positive regulation of execution phase of apoptosis	IDA IDA: Inferred from direct assay	21971051	MGI
involved in positive regulation of fat cell differentiation	IDA IDA: Inferred from direct assay	19666473	MGI
involved in positive regulation of lipid storage	IMP IMP: Inferred from mutant phenotype	22739135	MGI
involved in positive regulation of mRNA catabolic process	IDA IDA: Inferred from direct assay	19322177	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19666473	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	19322177	MGI
located in nucleus	IDA IDA: Inferred from direct assay	16574901	MGI
located in rough endoplasmic reticulum	IDA IDA: Inferred from direct assay	26255671	MGI
located in rough endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	26000482	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

endoribonuclease ZC3H12A

MCP-1 treatment-induced protein	MCP-induced protein 1
bifunctional endoribonuclease and deubiquitinase ZC3H12A	monocyte chemotactic protein-induced protein 1
regnase-1	ribonuclease ZC3H12A
zinc finger CCCH domain-containing protein 12A

Zc3h12a Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Zc3h12a	Q5D1E7	IKBKB	Homo sapiens	O14920	Anti Tag CoIP	22037600

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15986	ZC3H12A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Zc3h12a	NCBI	NCBI:80149

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