2. Gene
  3. ZC3H12A - zinc finger CCCH-type containing 12A Gene

ZC3H12A - zinc finger CCCH-type containing 12A Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as Reg1; MCPIP; MCPIP1; MCPIP-1; dJ423B22.1

Gene ID: 80149 | Gene type: protein coding

About ZC3H12A

Cytogenetic location: 1p34.3 Genomic coordinates (GRCh38): 1:37,474,580-37,484,377 (from NCBI)

This gene has 4 transcripts (splice variants), 287 orthologues and 6 paralogues. Broad expression in bone marrow (RPKM 42.1), urinary bladder (RPKM 18.8) and 17 other tissues.

Summary

ZC3H12A is an MCP1 (CCL2; MIM 158105)-induced protein that acts as a transcriptional activator and causes cell death of cardiomyocytes, possibly via induction of genes associated with Apoptosis.[supplied by OMIM, Mar 2008]

ZC3H12A Products(3)

mRNA Protein Name
NM_001323550.2 NP_001310479.1 endoribonuclease ZC3H12A isoform a
NM_001323551.2 NP_001310480.1 endoribonuclease ZC3H12A isoform b
NM_025079.3 NP_079355.2 endoribonuclease ZC3H12A isoform a

ZC3H12A Protein Structure

RNase_Zc3h12a

RNase_Zc3h12a: Zc3h12a-like Ribonuclease NYN domain (135 - 289)

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  • 599 a.a.
Protein Preferred Names Protein Names

endoribonuclease ZC3H12A

MCP-1 treatment-induced protein

ZC3H12A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
ZC3H12A Q5D1E8 P4HA3 Homo sapiens Q7Z4N8
Validated Y2H
32296183
Intra
ZC3H12A Q5D1E8 P4HA3 Homo sapiens Q7Z4N8
Y2H Prey Pooling
25416956
Intra
ZC3H12A Q5D1E8 USP10 Homo sapiens Q14694
Anti Tag CoIP
24270572
Intra
ZC3H12A Q5D1E8 BTRC Homo sapiens Q9Y297
Y2H
21900206
Intra
ZC3H12A Q5D1E8 BTRC Homo sapiens Q9Y297
Anti Tag CoIP
24270572
Intra
ZC3H12A Q5D1E8 SMAD3 Homo sapiens P84022
Y2H
21988832
Intra
ZC3H12A Q5D1E8 SMAD3 Homo sapiens P84022
Anti Tag CoIP
21988832
Intra
ZC3H12A Q5D1E8 IRAK2 Homo sapiens O43187
Anti Tag CoIP
21903422
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Japanese Encephalitis

Japanese B Encephalitis

Je

Encephalitis Japanese

Encephalitis, Japanese

Russian Autumnal Encephalitis

Je - [Japanese Encephalitis]

Japanese Encephalitis Virus Disease

Jbe - [Japanese B Encephalitis}

B Type Encephalitis
Autosomal Dominant Cerebellar Ataxia

Spinocerebellar Ataxia

Adca

Pierre Marie Cerebellar Ataxia

Ataxia, Spinocerebellar

Sca

Autosomal Dominant Spinocerebellar Ataxia

Spinocerebellar Ataxias
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15986 ZC3H12A Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ZC3H12A VGNC VGNC:37097
Canis familiaris ZC3H12A VGNC VGNC:48551
Macaca mulatta ZC3H12A VGNC VGNC:79595
Felis catus ZC3H12A VGNC VGNC:67181
Rattus norvegicus ZC3H12A RGD RGD:1306776
Mus musculus ZC3H12A MGD MGI:2385891