MYCBP2 - MYC binding protein 2 Gene

Homo sapiens

Also known as PAM; Phr; PHR1; Myc-bp2

Gene ID: 23077 | Gene type: protein coding

About MYCBP2

Cytogenetic location: 13q22.3 Genomic coordinates (GRCh38): 13:77,044,657-77,327,094 (from NCBI)

This gene has 29 transcripts (splice variants), 223 orthologues and 1 paralogue. Ubiquitous expression in skin (RPKM 12.3), brain (RPKM 10.8) and 25 other tissues.

Summary

This gene encodes an E3 ubiquitin-protein Ligase and member of the PHR (Phr1/MYCBP2, highwire and RPM-1) family of proteins. The encoded protein plays a role in axon guidance and synapse formation in the developing nervous system. In mammalian cells, this protein regulates the cAMP and mTOR signaling pathways, and may additionally regulate Autophagy. Reduced expression of this gene has been observed in acute lymphoblastic leukemia patients and a mutation in this gene has been identified in patients with a rare inherited vision defect. [provided by RefSeq, Mar 2017]

MYCBP2 Products(1)

mRNA	Protein	Name
NM_015057.5	NP_055872.4	E3 ubiquitin-protein ligase MYCBP2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables guanyl-nucleotide exchange factor activity	IDA IDA: Inferred from direct assay	26304119	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15161933	GOA
enables small GTPase binding	IDA IDA: Inferred from direct assay	26304119	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	29643511	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	29643511	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in circadian regulation of gene expression	IMP IMP: Inferred from mutant phenotype	20534529	GOA
involved in positive regulation of protein ubiquitination	IDA IDA: Inferred from direct assay	20534529	GOA
involved in protein K48-linked ubiquitination	IDA IDA: Inferred from direct assay	29997255	GOA
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	29643511	GOA
involved in protein ubiquitination	IMP IMP: Inferred from mutant phenotype	27278822	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	26304119	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MYCBP2 Protein Structure

RCC1_2

RCC1

PHR

Filamin

SH3_3

zf-RING_2

0
800
1600
2400
3200
4000
4640 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase MYCBP2

Highwire

MYCBP2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MYCBP2	O75592	YWHAZ	Homo sapiens	P63104	Pull Down	15161933
Cross	MYCBP2	O75592	Rae1	Rattus norvegicus	Q3SWS8	Anti Tag CoIP	22357847
Cross	MYCBP2	O75592	Q99IB8-PRO_0000045603	Hepatitis C virus	Q99IB8-PRO_0000045603	Pull Down	24136289
Cross	MYCBP2	O75592	Q99IB8-PRO_0000045603	Hepatitis C virus	Q99IB8-PRO_0000045603	Y2H	24136289

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08881	MYCBP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	MYCBP2	VGNC	VGNC:75011
Canis familiaris	MYCBP2	VGNC	VGNC:43528
Bos taurus	MYCBP2	VGNC	VGNC:31785
Felis catus	MYCBP2	VGNC	VGNC:63670
Rattus norvegicus	MYCBP2	RGD	RGD:1312048
Mus musculus	MYCBP2	MGD	MGI:2179432

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