MRPS27 - mitochondrial ribosomal protein S27 Gene

Homo sapiens

Also known as S27mt; MRP-S27

Gene ID: 23107 | Gene type: protein coding

About MRPS27

Cytogenetic location: 5q13.2 Genomic coordinates (GRCh38): 5:72,219,403-72,320,240 (from NCBI)

This gene has 32 transcripts (splice variants) and 205 orthologues. Ubiquitous expression in thyroid (RPKM 20.7), heart (RPKM 19.0) and 25 other tissues.

Summary

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that may be a functional partner of the death associated protein 3 (DAP3). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2013]

MRPS27 Products(3)

mRNA	Protein	Name
NM_001286748.2	NP_001273677.1	28S ribosomal protein S27, mitochondrial isoform 1
NM_001286751.2	NP_001273680.1	28S ribosomal protein S27, mitochondrial isoform 3
NM_015084.3	NP_055899.2	28S ribosomal protein S27, mitochondrial isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables mitochondrial ribosome binding	IDA IDA: Inferred from direct assay	22841715	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19103604	GOA
enables rRNA binding	IDA IDA: Inferred from direct assay	22841715	GOA
enables tRNA binding	IDA IDA: Inferred from direct assay	22841715	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell population proliferation	IMP IMP: Inferred from mutant phenotype	28714366	GOA
involved in positive regulation of mitochondrial translation	IMP IMP: Inferred from mutant phenotype	22841715	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	28714366	GOA
part of mitochondrial small ribosomal subunit	IDA IDA: Inferred from direct assay	22841715	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	22841715	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MRPS27 Protein Structure

MRP-S27

0
100
200
300
414 a.a.

Protein Preferred Names

Protein Names

28S ribosomal protein S27, mitochondrial

mitochondrial 28S ribosomal protein S27

MRPS27 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MRPS27	Q92552	CFTR	Homo sapiens	P13569	Ub Reconstruction	35156780
Intra	MRPS27	Q92552	MRPS18B	Homo sapiens	Q9Y676	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Plethora Of Newborn

Neonatal Polycythemia

Leigh Syndrome

Leigh Disease	Infantile Subacute Necrotizing Encephalopathy
Leigh Syndrome Due To Mitochondrial Complex Iv Deficiency	LS
Sne	Leigh'S Disease
Leigh Syndrome Due To Mitochondrial Complex I Deficiency	Necrotizing Encephalopathy, Infantile Subacute, Of Leigh
Subacute Necrotizing Encephalomyelopathy	Necrotizing Encephalopathy Infantile Subacute Of Leigh
Leigh Syndrome Due To Mitochondrial Complex Iii Deficiency	Infantile Necrotizing Encephalomyelopathy
Juvenile Subacute Necrotizing Encephalomyelopathy	Leigh'S Necrotizing Encephalopathy
Subacute Necrotizing Encephalopathy	Juvenile Subacute Necrotizing Encephalopathy
Leigh Syndrome Due To Mitochondrial Complex Ii Deficiency	Leigh Syndrome Due To Mitochondrial Complex V Deficiency
Encephalopathy, Subacute Necrotizing, Infantile	Encephalopathy, Subacute Necrotizing, Juvenile
Maternally Inherited Leigh Syndrome	Subacute Necrotising Encephalomyelopathy
Subacute Necrotising Encephalopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08682	MRPS27 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MRPS27	MGD	MGI:1919064
Canis familiaris	MRPS27	VGNC	VGNC:43418
Rattus norvegicus	MRPS27	RGD	RGD:1311829
Macaca mulatta	MRPS27	VGNC	VGNC:74765
Felis catus	MRPS27	VGNC	VGNC:63622
Bos taurus	MRPS27	VGNC	VGNC:31667

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