MRPS18B - mitochondrial ribosomal protein S18B Gene

Homo sapiens

Also known as PTD017; S18amt; C6orf14; HSPC183; MRPS18-2; HumanS18a; MRP-S18-2

Gene ID: 28973 | Gene type: protein coding

About MRPS18B

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:30,617,840-30,626,392 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele and 202 orthologues. Ubiquitous expression in heart (RPKM 30.3), thyroid (RPKM 26.9) and 25 other tissues.

Summary

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S18P family. The encoded protein is one of three that has significant sequence similarity to Bacterial S18 proteins. The primary sequences of the three human mitochondrial S18 proteins are no more closely related to each other than they are to the prokaryotic S18 proteins. Pseudogenes corresponding to this gene are found on chromosomes 1q and 2q. [provided by RefSeq, Jul 2008]

MRPS18B Products(1)

mRNA	Protein	Name
NM_014046.4	NP_054765.1	28S ribosomal protein S18b, mitochondrial

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18391203	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of mitochondrial small ribosomal subunit	IDA IDA: Inferred from direct assay	25838379	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MRPS18B Protein Structure

Ribosomal_S18

0
100
200
258 a.a.

Protein Preferred Names

Protein Names

28S ribosomal protein S18b, mitochondrial

28S ribosomal protein S18-2, mitochondrial

Related Diseases

Diseases

Alias

Loeys-Dietz Syndrome 4

LDS4	Aneurysm, Aortic And Cerebral, With Arterial Tortuosity And Skeletal Manifestations
Loeys-Dietz Syndrome Type 4	Aortic And Cerebral Aneurysm With Arterial Tortuosity And Skeletal Manifestations
Loeys-Dietz Syndrome, Type 4

Megaesophagus

Esophageal Achalasia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08677	MRPS18B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	MRPS18B	VGNC	VGNC:43413
Bos taurus	MRPS18B	VGNC	VGNC:50008
Macaca mulatta	MRPS18B	VGNC	VGNC:74768
Rattus norvegicus	MRPS18B	RGD	RGD:1302998
Mus musculus	MRPS18B	MGD	MGI:1914223
Felis catus	MRPS18B	VGNC	VGNC:63616

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