MAST2 - microtubule associated serine/threonine kinase 2 Gene

Homo sapiens

Also known as MTSSK; MAST205

Gene ID: 23139 | Gene type: protein coding

About MAST2

Cytogenetic location: 1p34.1 Genomic coordinates (GRCh38): 1:45,803,612-46,036,122 (from NCBI)

This gene has 10 transcripts (splice variants), 227 orthologues and 13 paralogues. Broad expression in testis (RPKM 25.4), heart (RPKM 11.8) and 23 other tissues.

Summary

Enables Phosphatase binding activity. Predicted to be involved in several processes, including peptidyl-serine phosphorylation; regulation of interleukin-12 production; and spermatid differentiation. Predicted to be located in cytoplasm and plasma membrane. Predicted to be active in microtubule Cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022]

MAST2 Products(4)

mRNA	Protein	Name
NM_001319245.2	NP_001306174.1	microtubule-associated serine/threonine-protein kinase 2 isoform 2
NM_001324320.2	NP_001311249.1	microtubule-associated serine/threonine-protein kinase 2 isoform 3
NM_001324321.2	NP_001311250.1	microtubule-associated serine/threonine-protein kinase 2 isoform 4
NM_015112.3	NP_055927.2	microtubule-associated serine/threonine-protein kinase 2 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables phosphatase binding	IPI IPI: Inferred from physical interaction	10646847	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12117771	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAST2 Protein Structure

DUF1908

Pkinase

PDZ

0
300
600
900
1200
1500
1798 a.a.

Protein Preferred Names

Protein Names

microtubule-associated serine/threonine-protein kinase 2

microtubule associated testis specific serine/threonine protein kinase

Related Diseases

Diseases

Alias

Mega-Corpus-Callosum Syndrome With Cerebellar Hypoplasia And Cortical Malformations

MCCCHCM

Inflammatory Bowel Disease 6

IBD6

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08162	MAST2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MAST2	VGNC	VGNC:31258
Mus musculus	MAST2	MGD	MGI:894676
Macaca mulatta	MAST2	VGNC	VGNC:74532
Canis familiaris	MAST2	VGNC	VGNC:43033
Rattus norvegicus	MAST2	RGD	RGD:1304573
Felis catus	MAST2	VGNC	VGNC:80276

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