CDHR2 - cadherin related family member 2 Gene

Homo sapiens

Also known as PCLCK; PCLKC; PCDH24

Gene ID: 54825 | Gene type: protein coding

About CDHR2

Cytogenetic location: 5q35.2 Genomic coordinates (GRCh38): 5:176,542,511-176,595,974 (from NCBI)

This gene has 7 transcripts (splice variants), 116 orthologues and 33 paralogues. Biased expression in duodenum (RPKM 125.9), small intestine (RPKM 110.9) and 3 other tissues.

Summary

This gene is a member of the protocadherin family, which represents a subset of the larger cadherin superfamily. The members of the protocadherin family encode non-classical Cadherins that function as calcium-dependent cell-cell adhesion molecules. This protocadherin represents a new candidate for tumor suppression. Alternatively spliced transcript variants that encode the same protein have been identified. [provided by RefSeq, Jan 2010]

CDHR2 Products(2)

mRNA	Protein	Name
NM_001171976.2	NP_001165447.1	cadherin-related family member 2 precursor
NM_017675.6	NP_060145.3	cadherin-related family member 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cell adhesion molecule binding	IDA IDA: Inferred from direct assay	24725409	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12117771	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in brush border assembly	IDA IDA: Inferred from direct assay	32209652	GOA
involved in cell-cell adhesion mediated by cadherin	IDA IDA: Inferred from direct assay	12117771	GOA
involved in epithelial cell differentiation	IDA IDA: Inferred from direct assay	12117771	GOA
involved in intermicrovillar adhesion	IMP IMP: Inferred from mutant phenotype	24725409	GOA
involved in negative regulation of cell growth involved in contact inhibition	IDA IDA: Inferred from direct assay	12117771	GOA
involved in regulation of microvillus length	IMP IMP: Inferred from mutant phenotype	24725409	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	12117771	GOA
located in brush border	IDA IDA: Inferred from direct assay	21330445	GOA
located in brush border membrane	IDA IDA: Inferred from direct assay	24725409	GOA
located in microvillus	IDA IDA: Inferred from direct assay	32209652	GOA
located in microvillus membrane	IDA IDA: Inferred from direct assay	12117771	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	24725409	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDHR2 Protein Structure

Cadherin

0
300
600
900
1200
1310 a.a.

Protein Preferred Names

Protein Names

cadherin-related family member 2

protocadherin-24

CDHR2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CDHR2	Q9BYE9	MYO7B	Homo sapiens	Q6PIF6	Anti Tag CoIP	24725409
Intra	CDHR2	Q9BYE9	MYO7B	Homo sapiens	Q6PIF6	Confocal	24725409
Intra	CDHR2	Q9BYE9	MAST2	Homo sapiens	Q6P0Q8	Y2H	12117771
Intra	CDHR2	Q9BYE9	CDHR5	Homo sapiens	Q9HBB8-1	Pull Down	24725409
Intra	CDHR2	Q9BYE9	CDHR5	Homo sapiens	Q9HBB8-1	SEM	24725409
Intra	CDHR2	Q9BYE9	USH1C	Homo sapiens	Q9Y6N9-1	Anti Tag CoIP	24725409
Intra	CDHR2	Q9BYE9	CDHR5	Homo sapiens	Q9HBB8-2	Pull Down	24725409
Intra	CDHR2	Q9BYE9	CDHR5	Homo sapiens	Q9HBB8-2	SEM	24725409
Intra	CDHR2	Q9BYE9	CDHR5	Homo sapiens	Q9HBB8-2	Bead Aggregation	24725409

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Usher Syndrome

Deafness-Retinitis Pigmentosa Syndrome	Dystrophia Retinae Pigmentosa-Dysostosis Syndrome
Graefe-Usher Syndrome	Hallgren Syndrome
Usher'S Syndrome	Retinitis Pigmentosa-Deafness Syndrome
Retinitis Pigmentosa-Hearing Loss Syndrome	Ush
Usher Syndromes

Usher Syndrome, Type I

USH1	Usher Syndrome Type 1
Us1	Usher Syndrome, Type 1b
Usher Syndrome Type 1e	Retinitis Pigmentosa And Congenital Deafness
Usher Syndrome, Type Ie	USH1E
Usher Syndrome, Type 1e	Usher Syndrome, Type 1a
Usher Syndrome, Type Ib	Usher Syndrome Type 1b
Usher Syndrome Type Ie	Usher Syndrome Type I
Usher 1	Usher Syndrome, Type 1
Ush1a	Usher Syndrome, Type I, French Variety
Usher Syndrome, Type Ia	Usher Syndrome 1b
USH1B	Usher'S Syndrome Type 1b
Usher Syndrome Type Ib	Ushib

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02344	CDHR2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CDHR2	RGD	RGD:1560576
Bos taurus	CDHR2	VGNC	VGNC:27109
Canis familiaris	CDHR2	VGNC	VGNC:39038
Mus musculus	CDHR2	MGD	MGI:2687323
Felis catus	CDHR2	VGNC	VGNC:60689
Macaca mulatta	CDHR2	VGNC	VGNC:110476

Name
Email *

	Sorry, but the email address you supplied was invalid.