MPRIP - myosin phosphatase Rho interacting protein Gene

Homo sapiens

Also known as MRIP; RIP3; M-RIP; RHOIP3; p116Rip

Gene ID: 23164 | Gene type: protein coding

About MPRIP

Cytogenetic location: 17p11.2 Genomic coordinates (GRCh38): 17:17,042,457-17,192,643 (from NCBI)

This gene has 21 transcripts (splice variants), 249 orthologues and 1 paralogue. Ubiquitous expression in endometrium (RPKM 19.8), brain (RPKM 18.4) and 25 other tissues.

Summary

Enables cadherin binding activity. Predicted to be involved in actin filament organization. Located in actin Cytoskeleton and cytosol. [provided by Alliance of Genome Resources, Apr 2022]

MPRIP Products(3)

mRNA	Protein	Name
NM_001364716.4	NP_001351645.2	myosin phosphatase Rho-interacting protein isoform 3
NM_015134.4	NP_055949.2	myosin phosphatase Rho-interacting protein isoform 1
NM_201274.4	NP_958431.2	myosin phosphatase Rho-interacting protein isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15161933	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MPRIP Protein Structure

0
200
400
600
800
1025 a.a.

Protein Preferred Names

Protein Names

myosin phosphatase Rho-interacting protein

Rho interacting protein 3

MPRIP Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MPRIP	Q6WCQ1	YWHAZ	Homo sapiens	P63104	Pull Down	15161933
Intra	MPRIP	Q6WCQ1	YWHAQ	Homo sapiens	P27348	CoIP	15324660
Intra	MPRIP	Q6WCQ1	YWHAQ	Homo sapiens	P27348	Y2H	21988832
Intra	MPRIP	Q6WCQ1	SFN	Homo sapiens	P31947	TAP	15778465
Cross	MPRIP	Q6WCQ1	Ppp1r12a	Rattus norvegicus	Q10728	Y2H	15545284
Cross	MPRIP	Q6WCQ1	Ppp1r12a	Rattus norvegicus	Q10728	Anti Tag CoIP	15545284
Cross	MPRIP	Q6WCQ1	Ppp1r12a	Rattus norvegicus	Q10728	Pull Down	15545284

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Congenital Mesoblastic Nephroma

Mesoblastic Nephroma

Nephroma, Mesoblastic

Cellular Congenital Mesoblastic Nephroma

Optic Atrophy 10 With Or Without Ataxia, Mental Retardation, And Seizures

OPA10	Optic Atrophy 10 With Or Without Ataxia, Intellectual Disability, And Seizures
Optic Atrophy 10	Atrophy, Optic, Type 10, With/Without Ataxia, Mental Retardation, And Seizures

Congenital Fibrosarcoma

Infantile Fibrosarcoma

Childhood Fibrosarcoma

Pediatric Fibrosarcoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08629	MPRIP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	MPRIP	VGNC	VGNC:54331
Rattus norvegicus	MPRIP	RGD	RGD:619947
Felis catus	MPRIP	VGNC	VGNC:63576
Mus musculus	MPRIP	MGD	MGI:1349438
Bos taurus	MPRIP	VGNC	VGNC:57144
Macaca mulatta	MPRIP	VGNC	VGNC:74867

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