OTUD3 - OTU deubiquitinase 3 Gene

Homo sapiens

Also known as DUBA4

Gene ID: 23252 | Gene type: protein coding

About OTUD3

Cytogenetic location: 1p36.13 Genomic coordinates (GRCh38): 1:19,882,395-19,912,945 (from NCBI)

This gene has 3 transcripts (splice variants), 211 orthologues and 5 paralogues. Broad expression in testis (RPKM 8.1), endometrium (RPKM 3.2) and 23 other tissues.

Summary

Enables thiol-dependent Deubiquitinase. Acts upstream of or within negative regulation of protein kinase B signaling; protein deubiquitination; and protein stabilization. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

OTUD3 Products(1)

mRNA	Protein	Name
NM_015207.2	NP_056022.1	OTU domain-containing protein 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cysteine-type deubiquitinase activity	IDA IDA: Inferred from direct assay	23827681	GOA
enables cysteine-type deubiquitinase activity	IMP IMP: Inferred from mutant phenotype	26280536	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	26280536	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to nutrient levels	IDA IDA: Inferred from direct assay	35675826	GOA
acts upstream of or within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	26280536	GOA
acts upstream of or within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	26280536	GOA
acts upstream of or within protein K11-linked deubiquitination	IDA IDA: Inferred from direct assay	26280536	GOA
involved in protein K11-linked deubiquitination	IDA IDA: Inferred from direct assay	23827681	GOA
acts upstream of or within protein K27-linked deubiquitination	IDA IDA: Inferred from direct assay	26280536	GOA
acts upstream of or within protein K48-linked deubiquitination	IDA IDA: Inferred from direct assay	26280536	GOA
involved in protein K48-linked deubiquitination	IDA IDA: Inferred from direct assay	35675826	GOA
acts upstream of or within protein K6-linked deubiquitination	IDA IDA: Inferred from direct assay	26280536	GOA
involved in protein K6-linked deubiquitination	IDA IDA: Inferred from direct assay	23827681	GOA
involved in protein deubiquitination	IDA IDA: Inferred from direct assay	32011234	GOA
acts upstream of or within protein stabilization	IDA IDA: Inferred from direct assay	26280536	GOA
involved in protein stabilization	IDA IDA: Inferred from direct assay	35675826	GOA
acts upstream of or within protein stabilization	IMP IMP: Inferred from mutant phenotype	26280536	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	26280536	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	35675826	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OTUD3 Protein Structure

OTU

0
100
200
300
398 a.a.

Protein Preferred Names

Protein Names

OTU domain-containing protein 3

OTU domain containing 3

OTUD3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	OTUD3	Q5T2D3	PTEN	Homo sapiens	P60484-1	Anti Tag CoIP	26280536
Intra	OTUD3	Q5T2D3	PTEN	Homo sapiens	P60484-1	Pull Down	26280536
Intra	OTUD3	Q5T2D3	HSD17B14	Homo sapiens	Q9BPX1	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09872	OTUD3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	OTUD3	RGD	RGD:1560468
Macaca mulatta	OTUD3	VGNC	VGNC:100022
Felis catus	OTUD3	VGNC	VGNC:80296
Mus musculus	OTUD3	MGD	MGI:1920412
Canis familiaris	OTUD3	VGNC	VGNC:44185
Bos taurus	OTUD3	VGNC	VGNC:32494
Others	OTUD3	NCBI

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