SCFD1 - sec1 family domain containing 1 Gene

Homo sapiens

Also known as SLY1; RA410; SLY1P; STXBP1L2; C14orf163

Gene ID: 23256 | Gene type: protein coding

About SCFD1

Cytogenetic location: 14q12 Genomic coordinates (GRCh38): 14:30,622,254-30,735,850 (from NCBI)

This gene has 72 transcripts (splice variants), 213 orthologues and 7 paralogues. Ubiquitous expression in thyroid (RPKM 19.4), testis (RPKM 13.5) and 25 other tissues.

Summary

Predicted to enable syntaxin binding activity. Involved in negative regulation of autophagosome assembly; regulation of protein transport; and response to toxic substance. Located in cis-Golgi network. [provided by Alliance of Genome Resources, Apr 2022]

SCFD1 Products(6)

mRNA	Protein	Name
NM_001257376.1	NP_001244305.1	sec1 family domain-containing protein 1 isoform c
NM_001283031.1	NP_001269960.1	sec1 family domain-containing protein 1 isoform d
NM_001283032.1	NP_001269961.1	sec1 family domain-containing protein 1 isoform e
NM_001283033.1	NP_001269962.1	sec1 family domain-containing protein 1 isoform d
NM_016106.4	NP_057190.2	sec1 family domain-containing protein 1 isoform a
NM_182835.2	NP_878255.1	sec1 family domain-containing protein 1 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19536132	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of autophagosome assembly	IMP IMP: Inferred from mutant phenotype	21242315	GOA
involved in regulation of protein transport	IMP IMP: Inferred from mutant phenotype	21242315	GOA
involved in response to toxic substance	IEP IEP: Inferred from expression pattern	15649705	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cis-Golgi network	IDA IDA: Inferred from direct assay	15649705	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SCFD1 Protein Structure

Sec1

0
100
200
300
400
500
600
642 a.a.

Protein Preferred Names

Protein Names

sec1 family domain-containing protein 1

syntaxin-binding protein 1-like 2

SCFD1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SCFD1	Q8WVM8	COG4	Homo sapiens	Q9H9E3	Pull Down	19536132
Intra	SCFD1	Q8WVM8	COG4	Homo sapiens	Q9H9E3	Anti Tag CoIP	19536132

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Familial Adenomatous Polyposis 3

FAP3	Nthl1-Related Attenuated Familial Adenomatous Polyposis
Nthl1-Related Afap	Nthl1-Related Attenuated Fap

Achondrogenesis, Type Ia

Achondrogenesis Type Ia	Achondrogenesis Type 1a
ACG1A	Achondrogenesis, Houston-Harris Type
Achondrogenesis Houston-Harris Type	Achondrogenesis 1a
Acg-Ia

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12499	SCFD1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SCFD1	VGNC	VGNC:64907
Rattus norvegicus	SCFD1	RGD	RGD:619828
Bos taurus	SCFD1	VGNC	VGNC:34330
Mus musculus	SCFD1	MGD	MGI:1924233
Macaca mulatta	SCFD1	VGNC	VGNC:77065
Canis familiaris	SCFD1	VGNC	VGNC:45903

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