USP22 - ubiquitin specific peptidase 22 Gene

Homo sapiens

Also known as USP3L

Gene ID: 23326 | Gene type: protein coding

About USP22

Cytogenetic location: 17p11.2 Genomic coordinates (GRCh38): 17:20,999,596-21,043,419 (from NCBI)

This gene has 11 transcripts (splice variants), 221 orthologues and 71 paralogues. Ubiquitous expression in brain (RPKM 54.0), ovary (RPKM 38.9) and 25 other tissues.

Summary

Enables Enzyme binding activity; nuclear receptor coactivator activity; and thiol-dependent Deubiquitinase. Contributes to H4 Histone Acetyltransferase activity. Involved in positive regulation of mitotic cell cycle; positive regulation of transcription, DNA-templated; and protein modification by small protein conjugation or removal. Part of SAGA complex. [provided by Alliance of Genome Resources, Apr 2022]

USP22 Products(1)

mRNA	Protein	Name
NM_015276.2	NP_056091.1	ubiquitin carboxyl-terminal hydrolase 22

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cysteine-type deubiquitinase activity	IDA IDA: Inferred from direct assay	16378762	GOA
contributes to cysteine-type deubiquitinase activity	IMP IMP: Inferred from mutant phenotype	18206973	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	23382074	GOA
enables histone H2A deubiquitinase activity	IDA IDA: Inferred from direct assay	18469533	GOA
enables histone H2B deubiquitinase activity	IDA IDA: Inferred from direct assay	18469533	GOA
contributes to histone H4 acetyltransferase activity	IDA IDA: Inferred from direct assay	18206973	GOA
enables nuclear receptor coactivator activity	IMP IMP: Inferred from mutant phenotype	18206972	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18206972	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	18206972	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in G2/M transition of mitotic cell cycle	IDA IDA: Inferred from direct assay	27030811	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	18206973	GOA
involved in positive regulation of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	18206973	GOA
involved in positive regulation of type I interferon production	IDA IDA: Inferred from direct assay	32130408	GOA
involved in protein deubiquitination	IDA IDA: Inferred from direct assay	16378762	GOA
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9603525	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of SAGA complex	IDA IDA: Inferred from direct assay	18206972	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

USP22 Protein Structure

zf-UBP

UCH

0
100
200
300
400
525 a.a.

Protein Preferred Names

Protein Names

ubiquitin carboxyl-terminal hydrolase 22

deubiquitinating enzyme 22

Related Diseases

Diseases

Alias

Glandular Tularemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15533	USP22 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	USP22	RGD	RGD:1310354
Bos taurus	USP22	VGNC	VGNC:36716
Canis familiaris	USP22	VGNC	VGNC:55013
Macaca mulatta	USP22	VGNC	VGNC:78742
Felis catus	USP22	VGNC	VGNC:66873
Mus musculus	USP22	MGD	MGI:2144157
Others	USP22	NCBI

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