USP22 - ubiquitin specific peptidase 22 Gene

Homo sapiens

Also known as USP3L

Gene ID: 23326 | Gene type: protein coding

About USP22

Cytogenetic location: 17p11.2 Genomic coordinates (GRCh38): 17:20,999,596-21,043,419 (from NCBI)

This gene has 11 transcripts (splice variants), 221 orthologues and 71 paralogues. Ubiquitous expression in brain (RPKM 54.0), ovary (RPKM 38.9) and 25 other tissues.

Summary

Enables Enzyme binding activity; nuclear receptor coactivator activity; and thiol-dependent Deubiquitinase. Contributes to H4 Histone Acetyltransferase activity. Involved in positive regulation of mitotic cell cycle; positive regulation of transcription, DNA-templated; and protein modification by small protein conjugation or removal. Part of SAGA complex. [provided by Alliance of Genome Resources, Apr 2022]

USP22 Products(1)

mRNA	Protein	Name
NM_015276.2	NP_056091.1	ubiquitin carboxyl-terminal hydrolase 22

USP22 Protein Structure

zf-UBP

UCH

0
100
200
300
400
525 a.a.

Protein Preferred Names

Protein Names

ubiquitin carboxyl-terminal hydrolase 22

deubiquitinating enzyme 22

Related Diseases

Diseases

Alias

Glandular Tularemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15533	USP22 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	USP22	RGD	RGD:1310354
Bos taurus	USP22	VGNC	VGNC:36716
Canis familiaris	USP22	VGNC	VGNC:55013
Macaca mulatta	USP22	VGNC	VGNC:78742
Felis catus	USP22	VGNC	VGNC:66873
Mus musculus	USP22	MGD	MGI:2144157
Others	USP22	NCBI

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