RRP8 - ribosomal RNA processing 8 Gene

Homo sapiens

Also known as NML; KIAA0409

Gene ID: 23378 | Gene type: protein coding

About RRP8

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:6,595,072-6,603,616 (from NCBI)

This gene has 5 transcripts (splice variants) and 195 orthologues. Ubiquitous expression in spleen (RPKM 2.0), lymph node (RPKM 1.9) and 25 other tissues.

Summary

Enables methylated histone binding activity. Involved in several processes, including cellular response to glucose starvation; intrinsic apoptotic signaling pathway by p53 class mediator; and regulation of gene expression. Located in several cellular components, including cytosol; nuclear lumen; and rDNA heterochromatin. Part of chromatin silencing complex. [provided by Alliance of Genome Resources, Apr 2022]

RRP8 Products(1)

mRNA	Protein	Name
NM_015324.4	NP_056139.1	ribosomal RNA-processing protein 8

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables methylated histone binding	IDA IDA: Inferred from direct assay	18485871	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18485871	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to glucose starvation	IMP IMP: Inferred from mutant phenotype	18485871	GOA
involved in energy homeostasis	IMP IMP: Inferred from mutant phenotype	18485871	GOA
involved in intrinsic apoptotic signaling pathway by p53 class mediator	IMP IMP: Inferred from mutant phenotype	21471221	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	18485871	GOA
involved in negative regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	18485871	GOA
involved in rDNA heterochromatin formation	IDA IDA: Inferred from direct assay	18485871	GOA
involved in rDNA heterochromatin formation	IMP IMP: Inferred from mutant phenotype	18485871	GOA
acts upstream of negative effect regulation of G1 to G0 transition	IMP IMP: Inferred from mutant phenotype	21471221	GOA
involved in regulation of transcription by glucose	IMP IMP: Inferred from mutant phenotype	18485871	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of chromatin silencing complex	IDA IDA: Inferred from direct assay	18485871	GOA
part of eNoSc complex	IPI IPI: Inferred from physical interaction	18485871	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	18485871	GOA
located in rDNA heterochromatin	IDA IDA: Inferred from direct assay	18485871	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RRP8 Protein Structure

Methyltransf_8

0
100
200
300
400
456 a.a.

Protein Preferred Names

Protein Names

ribosomal RNA-processing protein 8

RRP8 methyltransferase homolog

RRP8 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RRP8	O43159	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	RRP8	O43159	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	RRP8	O43159	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	RRP8	O43159	SIRT1	Homo sapiens	Q96EB6	Anti Tag CoIP	18485871
Intra	RRP8	O43159	SIRT1	Homo sapiens	Q96EB6	Anti Bait CoIP	18485871
Intra	RRP8	O43159	SUV39H1	Homo sapiens	O43463	Anti Bait CoIP	18485871
Intra	RRP8	O43159	SUV39H1	Homo sapiens	O43463	Anti Tag CoIP	18485871
Intra	RRP8	O43159	DVL3	Homo sapiens	Q92997	Y2H Prey Pooling	32296183
Intra	RRP8	O43159	DVL3	Homo sapiens	Q92997	Validated Y2H	32296183
Intra	RRP8	O43159	DVL3	Homo sapiens	Q92997	Y2H Array	32296183
Intra	RRP8	O43159	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	RRP8	O43159	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183
Intra	RRP8	O43159	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12292	RRP8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RRP8	VGNC	VGNC:64782
Rattus norvegicus	RRP8	RGD	RGD:1308302
Canis familiaris	RRP8	VGNC	VGNC:52288
Macaca mulatta	RRP8	VGNC	VGNC:77120
Bos taurus	RRP8	VGNC	VGNC:34171
Mus musculus	RRP8	MGD	MGI:1914251

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