SUV39H1 - SUV39H1 histone lysine methyltransferase Gene

Homo sapiens

Also known as MG44; KMT1A; SUV39H; H3-K9-HMTase 1

Gene ID: 6839 | Gene type: protein coding

About SUV39H1

Cytogenetic location: Xp11.23 Genomic coordinates (GRCh38): X:48,695,554-48,709,016 (from NCBI)

This gene has 4 transcripts (splice variants), 221 orthologues and 19 paralogues. Ubiquitous expression in bone marrow (RPKM 4.9), lymph node (RPKM 3.6) and 24 other tissues.

Summary

This gene encodes an evolutionarily-conserved protein containing an N-terminal chromodomain and a C-terminal SET domain. The encoded protein is a Histone Methyltransferase that trimethylates lysine 9 of histone H3, which results in transcriptional gene silencing. Loss of function of this gene disrupts heterochromatin formation and may cause chromosome instability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

SUV39H1 Products(2)

mRNA	Protein	Name
NM_001282166.2	NP_001269095.1	histone-lysine N-methyltransferase SUV39H1 isoform 1
NM_003173.4	NP_003164.1	histone-lysine N-methyltransferase SUV39H1 isoform 2

SUV39H1 Protein Structure

Chromo

Pre-SET

SET

0
100
200
300
412 a.a.

Protein Preferred Names

Protein Names

histone-lysine N-methyltransferase SUV39H1

Su(var)3-9 homolog 1

SUV39H1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SUV39H1	O43463	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	32296183
Intra	SUV39H1	O43463	KRTAP10-8	Homo sapiens	P60410	Y2H Array	32296183
Intra	SUV39H1	O43463	KRTAP10-8	Homo sapiens	P60410	Validated Y2H	32296183
Intra	SUV39H1	O43463	KRTAP10-7	Homo sapiens	P60409	Validated Y2H	32296183
Intra	SUV39H1	O43463	KRTAP10-7	Homo sapiens	P60409	Y2H Array	25416956
Intra	SUV39H1	O43463	KRTAP10-7	Homo sapiens	P60409	Y2H Array	32296183
Intra	SUV39H1	O43463	KRTAP10-7	Homo sapiens	P60409	Y2H Prey Pooling	25416956
Intra	SUV39H1	O43463	KRTAP10-7	Homo sapiens	P60409	Y2H Prey Pooling	32296183
Intra	SUV39H1	O43463	HEL25	Homo sapiens	V9HWG0	Validated Y2H	25416956
Intra	SUV39H1	O43463	HEL25	Homo sapiens	V9HWG0	Y2H Array	25416956
Intra	SUV39H1	O43463	ATE1	Homo sapiens	O95260	Y2H	23455924
Intra	SUV39H1	O43463	PADI6	Homo sapiens	Q6TGC4	Y2H Prey Pooling	32296183
Intra	SUV39H1	O43463	PADI6	Homo sapiens	Q6TGC4	Validated Y2H	32296183
Intra	SUV39H1	O43463	PADI6	Homo sapiens	Q6TGC4	Y2H Array	32296183
Intra	SUV39H1	O43463	HOOK2	Homo sapiens	Q96ED9-2	Validated Y2H	32296183
Intra	SUV39H1	O43463	HOOK2	Homo sapiens	Q96ED9-2	Y2H Prey Pooling	32296183
Intra	SUV39H1	O43463	HOOK2	Homo sapiens	Q96ED9-2	Y2H Array	32296183
Intra	SUV39H1	O43463	ATN1	Homo sapiens	Q86V38	Y2H Pooling	32814053
Intra	SUV39H1	O43463	ATN1	Homo sapiens	Q86V38	Validated Y2H	32814053
Intra	SUV39H1	O43463	ATN1	Homo sapiens	Q86V38	Y2H Array	32814053
Intra	SUV39H1	O43463	ZNF438	Homo sapiens	Q7Z4V0	Y2H Prey Pooling	32296183
Intra	SUV39H1	O43463	ZNF438	Homo sapiens	Q7Z4V0	Validated Y2H	32296183
Intra	SUV39H1	O43463	ZNF438	Homo sapiens	Q7Z4V0	Y2H Array	32296183
Intra	SUV39H1	O43463	RRP8	Homo sapiens	O43159	Anti Tag CoIP	18485871
Intra	SUV39H1	O43463	KLK6	Homo sapiens	Q92876	Validated Y2H	32814053
Intra	SUV39H1	O43463	KLK6	Homo sapiens	Q92876	Y2H Pooling	32814053
Intra	SUV39H1	O43463	KLK6	Homo sapiens	Q92876	Y2H Array	32814053
Intra	SUV39H1	O43463	ZBTB2	Homo sapiens	Q8N680	Y2H Prey Pooling	32296183
Intra	SUV39H1	O43463	ZBTB2	Homo sapiens	Q8N680	Validated Y2H	32296183
Intra	SUV39H1	O43463	ZBTB2	Homo sapiens	Q8N680	Y2H Array	32296183
Intra	SUV39H1	O43463	SPSB1	Homo sapiens	Q96BD6	Anti Tag CoIP	23455924
Intra	SUV39H1	O43463	ZKSCAN5	Homo sapiens	Q9Y2L8	Anti Tag CoIP	23455924
Intra	SUV39H1	O43463	ZKSCAN5	Homo sapiens	Q9Y2L8	Y2H	23455924
Intra	SUV39H1	O43463	TGFBR2	Homo sapiens	P37173	Y2H Pooling	32814053
Intra	SUV39H1	O43463	TGFBR2	Homo sapiens	P37173	Validated Y2H	32814053
Intra	SUV39H1	O43463	TGFBR2	Homo sapiens	P37173	Y2H Array	32814053
Intra	SUV39H1	O43463	HDAC2	Homo sapiens	Q92769	Anti Tag CoIP	12711603
Intra	SUV39H1	O43463	HDAC2	Homo sapiens	Q92769	Pull Down	12711603
Intra	SUV39H1	O43463	HDAC1	Homo sapiens	Q13547	Pull Down	12711603
Intra	SUV39H1	O43463	HDAC1	Homo sapiens	Q13547	Anti Tag CoIP	12711603
Intra	SUV39H1	O43463	SERPINH1	Homo sapiens	P50454	Validated Y2H	32814053
Intra	SUV39H1	O43463	SERPINH1	Homo sapiens	P50454	Y2H Array	32814053
Intra	SUV39H1	O43463	SERPINH1	Homo sapiens	P50454	Y2H Pooling	32814053
Intra	SUV39H1	O43463	ZNF649	Homo sapiens	Q9BS31	Y2H	23455924
Intra	SUV39H1	O43463	ZRANB1	Homo sapiens	Q9UGI0	Y2H Prey Pooling	32296183
Intra	SUV39H1	O43463	ZRANB1	Homo sapiens	Q9UGI0	Validated Y2H	32296183
Intra	SUV39H1	O43463	ZRANB1	Homo sapiens	Q9UGI0	Y2H Array	32296183
Intra	SUV39H1	O43463	EZH2	Homo sapiens	Q15910	Y2H	23455924
Intra	SUV39H1	O43463	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Prey Pooling	32296183
Intra	SUV39H1	O43463	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Array	32296183
Intra	SUV39H1	O43463	U2AF1	Homo sapiens	Q01081	Y2H	23455924
Intra	SUV39H1	O43463	BCL11B	Homo sapiens	Q9C0K0	Anti Bait CoIP	17245431
Intra	SUV39H1	O43463	PPP1R16A	Homo sapiens	Q96I34	Y2H Prey Pooling	32296183
Intra	SUV39H1	O43463	PPP1R16A	Homo sapiens	Q96I34	Validated Y2H	32296183
Intra	SUV39H1	O43463	PPP1R16A	Homo sapiens	Q96I34	Y2H Array	32296183
Intra	SUV39H1	O43463	TRIM41	Homo sapiens	Q8WV44	Y2H Array	32296183
Intra	SUV39H1	O43463	TRIM41	Homo sapiens	Q8WV44	Validated Y2H	32296183
Intra	SUV39H1	O43463	TRIM41	Homo sapiens	Q8WV44	Y2H Prey Pooling	32296183
Intra	SUV39H1	O43463	CEP70	Homo sapiens	Q8NHQ1	Y2H Prey Pooling	25416956
Intra	SUV39H1	O43463	DVL3	Homo sapiens	Q92997	Y2H Prey Pooling	32296183
Intra	SUV39H1	O43463	DVL3	Homo sapiens	Q92997	Validated Y2H	32296183
Intra	SUV39H1	O43463	DVL3	Homo sapiens	Q92997	Y2H Array	32296183
Intra	SUV39H1	O43463	ZNF417	Homo sapiens	Q8TAU3	Y2H Prey Pooling	32296183
Intra	SUV39H1	O43463	ZNF417	Homo sapiens	Q8TAU3	Validated Y2H	32296183
Intra	SUV39H1	O43463	ZNF417	Homo sapiens	Q8TAU3	Y2H Array	32296183
Intra	SUV39H1	O43463	HOXA1	Homo sapiens	P49639	Anti Tag CoIP	23455924
Intra	SUV39H1	O43463	LZTS2	Homo sapiens	Q9BRK4	Y2H Array	32296183
Intra	SUV39H1	O43463	LZTS2	Homo sapiens	Q9BRK4	Y2H Prey Pooling	25416956
Intra	SUV39H1	O43463	LZTS2	Homo sapiens	Q9BRK4	Y2H Prey Pooling	32296183
Intra	SUV39H1	O43463	LZTS2	Homo sapiens	Q9BRK4	Validated Y2H	32296183
Intra	SUV39H1	O43463	LZTS2	Homo sapiens	Q9BRK4	Y2H Array	25416956
Intra	SUV39H1	O43463	ZNF670	Homo sapiens	Q9BS34	Anti Tag CoIP	23455924
Intra	SUV39H1	O43463	ZNF670	Homo sapiens	Q9BS34	Y2H	23455924
Intra	SUV39H1	O43463	RAD23A	Homo sapiens	P54725	Y2H Array	32814053
Intra	SUV39H1	O43463	RAD23A	Homo sapiens	P54725	Validated Y2H	32814053
Intra	SUV39H1	O43463	RAD23A	Homo sapiens	P54725	Y2H Pooling	32814053
Intra	SUV39H1	O43463	TEKT4	Homo sapiens	Q8WW24	Validated Y2H	32296183
Intra	SUV39H1	O43463	CBX1	Homo sapiens	P83916	Anti Tag CoIP	33961781
Intra	SUV39H1	O43463	CBX1	Homo sapiens	P83916	Validated Y2H	32296183
Intra	SUV39H1	O43463	CBX1	Homo sapiens	P83916	Y2H Array	32296183
Intra	SUV39H1	O43463	CBX1	Homo sapiens	P83916	Y2H Prey Pooling	32296183
Intra	SUV39H1	O43463	CBX1	Homo sapiens	P83916	TAP	27705803
Intra	SUV39H1	O43463	CBX3	Homo sapiens	Q13185	TAP	24981860
Intra	SUV39H1	O43463	CBX3	Homo sapiens	Q13185	TAP	27705803
Intra	SUV39H1	O43463	CBX3	Homo sapiens	Q13185	Anti Tag CoIP	33961781
Intra	SUV39H1	O43463	CBX3	Homo sapiens	Q13185	Validated Y2H	32296183
Intra	SUV39H1	O43463	CBX3	Homo sapiens	Q13185	Y2H Prey Pooling	32296183
Intra	SUV39H1	O43463	CBX3	Homo sapiens	Q13185	Y2H Array	32296183
Intra	SUV39H1	O43463	CBX5	Homo sapiens	P45973	TAP	27705803
Intra	SUV39H1	O43463	CBX5	Homo sapiens	P45973	Y2H Pooling	16189514
Intra	SUV39H1	O43463	CBX5	Homo sapiens	P45973	Validated Y2H	32296183
Intra	SUV39H1	O43463	CBX5	Homo sapiens	P45973	Anti Bait CoIP	25931448
Intra	SUV39H1	O43463	CBX5	Homo sapiens	P45973	TAP	24981860
Intra	SUV39H1	O43463	CBX5	Homo sapiens	P45973	Anti Tag CoIP	33961781
Intra	SUV39H1	O43463	CBX5	Homo sapiens	P45973	Y2H Array	32296183
Intra	SUV39H1	O43463	CBX5	Homo sapiens	P45973	Anti Tag CoIP	28514442
Intra	SUV39H1	O43463	CBX5	Homo sapiens	P45973	Pull Down	12711603
Intra	SUV39H1	O43463	CBX5	Homo sapiens	P45973	Y2H Prey Pooling	32296183
Intra	SUV39H1	O43463	C8orf74	Homo sapiens	Q6P047	Anti Tag CoIP	23455924
Intra	SUV39H1	O43463	ODAD3	Homo sapiens	A5D8V7	Anti Tag CoIP	23455924
Intra	SUV39H1	O43463	ODAD3	Homo sapiens	A5D8V7	Y2H	23455924
Intra	SUV39H1	O43463	KLHDC4	Homo sapiens	Q8TBB5	Anti Tag CoIP	23455924
Intra	SUV39H1	O43463	ZNF436	Homo sapiens	Q9C0F3	Anti Tag CoIP	23455924
Intra	SUV39H1	O43463	ZNF436	Homo sapiens	Q9C0F3	Y2H	23455924
Intra	SUV39H1	O43463	MBD1	Homo sapiens	Q9UIS9	Pull Down	12711603
Intra	SUV39H1	O43463	MBD1	Homo sapiens	Q9UIS9	Confocal	12711603
Intra	SUV39H1	O43463	MBD1	Homo sapiens	Q9UIS9	Anti Tag CoIP	12711603

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Hutchinson-Gilford Progeria Syndrome

Progeria	HGPS
Hutchinson-Gilford Syndrome	Hutchinson-Gilford Progeria
Hutchinson Gilford Syndrome	Hutchinson Gilford Progeria Syndrome
Hutchinson-Gilford Disease	Progeria Of Childhood
Hutchinson-Gilford-Progeria Syndrome

Hyperoxaluria, Primary, Type I

Primary Hyperoxaluria Type 1	HP1
Glycolic Aciduria	Alanine-Glyoxylate Aminotransferase Deficiency
Hepatic Agt Deficiency	Oxalosis I
Primary Hyperoxaluria, Type I	Serine:Pyruvate Aminotransferase Deficiency
Hyperoxaluria, Primary, Type 1	Peroxisomal Alanine-Glyoxylate Aminotransferase Deficiency
Peroxisomal Alanine Glyoxylate Aminotransferase Deficiency	Serine Pyruvate Aminotransferase Deficiency
Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency	Oxalosis 1
Hyperoxaluria Primary 1	Hyperoxaluria Primary Type I
Ph1	Primary Hyperoxaluria Type I
Oxalosis Type 1	2-Oxoglutarate Glyoxylate Carboligase Deficiency

Retinoblastoma

RB	Trilateral Retinoblastoma
RB1	Retinoblastoma, Trilateral
Neuroblastoma Of Retina	Rb - Retinoblastoma
Eye Cancer, Retinoblastoma	Retinal Cancer
Retinal Tumor	Glioma, Retinal
Non-Hereditary Retinoblastoma	Childhood Cancer Retinoblastoma
Malignant Neoplasm Of Retina	Retinal Neoplasms

Primary Hyperoxaluria

Hyperoxaluria	Hyperoxaluria, Primary
Oxalosis	Primary Oxalosis
Congenital Oxaluria	D-Glycerate Dehydrogenase Deficiency
Glyceric Aciduria	Glycolic Aciduria
Hepatic Agt Deficiency	Oxaluria, Primary
Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency	Primary Oxaluria
Hyperoxaluria Primary	Primary Hyperoxaluria Type 2
Primary Hyperoxaluria, Type I

Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome

Icf Syndrome	Immunodeficiency Syndrome, Variable
Ciid	Centromeric Instability, Immunodeficiency Syndrome
Immune Deficiency, Variable, With Centromeric Instability Of Chromosomes 1, 9, And 16	Icf

Rhabdomyosarcoma

Alpha-Thalassemia

Alpha Thalassemia	Alpha Thalassaemia
Alpha Plus Thalassemia	Thalassemia, Alpha-
Thalassemias, Alpha-	A-Thalassemia
Α-Thalassemia	A-THAL
Thalassemia	Alpha Thalassaemia Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-150190	F5446		99.38%	Unkown
HY-15647	BRD9539	Inhibitor	99.74%	Unkown
HY-RS14051	SUV39H1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SUV39H1	MGD	MGI:1099440
Bos taurus	SUV39H1	VGNC	VGNC:35491
Canis familiaris	SUV39H1	VGNC	VGNC:47001
Felis catus	SUV39H1	VGNC	VGNC:65857
Macaca mulatta	SUV39H1	VGNC	VGNC:78061

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