2. Gene
  3. SIK3 - SIK family kinase 3 Gene

SIK3 - SIK family kinase 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as L19; QSK; SEMDK; SIK-3

Gene ID: 23387 | Gene type: protein coding

About SIK3

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:116,843,402-117,098,428 (from NCBI)

This gene has 13 transcripts (splice variants), 224 orthologues, 17 paralogues and is associated with 1 phenotype. Broad expression in testis (RPKM 19.2), brain (RPKM 13.9) and 25 other tissues.

Summary

Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in positive regulation of TORC1 signaling; positive regulation of TORC2 signaling; and protein phosphorylation. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

SIK3 Products(22)

mRNA Protein Name
XM_047426671.1 XP_047282627.1 serine/threonine-protein kinase SIK3 isoform X1
NM_001366687.1 NP_001353616.1 serine/threonine-protein kinase SIK3 isoform 5
XM_047426676.1 XP_047282632.1 serine/threonine-protein kinase SIK3 isoform X13
XM_011542723.3 XP_011541025.1 serine/threonine-protein kinase SIK3 isoform X7
XM_005271484.4 XP_005271541.2 serine/threonine-protein kinase SIK3 isoform X5
XM_005271482.5 XP_005271539.2 serine/threonine-protein kinase SIK3 isoform X2
XM_005271485.4 XP_005271542.1 serine/threonine-protein kinase SIK3 isoform X8
NM_001281749.3 NP_001268678.1 serine/threonine-protein kinase SIK3 isoform 3
XM_017017425.2 XP_016872914.1 serine/threonine-protein kinase SIK3 isoform X7
XM_017017426.2 XP_016872915.1 serine/threonine-protein kinase SIK3 isoform X7
NM_025164.6 NP_079440.3 serine/threonine-protein kinase SIK3 isoform 1
XM_047426673.1 XP_047282629.1 serine/threonine-protein kinase SIK3 isoform X9
NM_001366686.3 NP_001353615.1 serine/threonine-protein kinase SIK3 isoform 4
XM_011542724.3 XP_011541026.1 serine/threonine-protein kinase SIK3 isoform X7
XM_047426675.1 XP_047282631.1 serine/threonine-protein kinase SIK3 isoform X12
XM_017017424.2 XP_016872913.1 serine/threonine-protein kinase SIK3 isoform X6
XM_011542725.3 XP_011541027.1 serine/threonine-protein kinase SIK3 isoform X7
NM_001281748.3 NP_001268677.1 serine/threonine-protein kinase SIK3 isoform 2
XM_047426674.1 XP_047282630.1 serine/threonine-protein kinase SIK3 isoform X11
XM_011542722.2 XP_011541024.1 serine/threonine-protein kinase SIK3 isoform X3
XM_047426672.1 XP_047282628.1 serine/threonine-protein kinase SIK3 isoform X4
XM_011542726.2 XP_011541028.1 serine/threonine-protein kinase SIK3 isoform X10
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables ATP binding IDA
IDA: Inferred from direct assay
14976552 GOA
enables magnesium ion binding IDA
IDA: Inferred from direct assay
14976552 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16306228 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
14976552 GOA
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of TORC1 signaling IMP
IMP: Inferred from mutant phenotype
30232230 GOA
involved in positive regulation of TORC2 signaling IMP
IMP: Inferred from mutant phenotype
30232230 GOA
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
14976552 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SIK3 Protein Structure

Pkinase

Pkinase: Protein kinase domain (8 - 259)

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  • 1263 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase SIK3

salt-inducible kinase 3

serine/threonine-protein kinase QSK

Related Diseases

Diseases Alias
Advanced Sleep Phase Syndrome

Fasps

Familial Advanced Sleep-Phase Syndrome

Advanced Sleep Phase Syndrome, Familial

Familial Advanced Sleep Phase Syndrome

Sleep Phase Syndrome, Advanced, Familial

Advanced Sleep-Phase Syndrome, Familial
Metaphyseal Chondrodysplasia, Jansen Type

Metaphyseal Chondrodysplasia, Murk Jansen Type

MCDJ

Jansen'S Metaphyseal Chondrodysplasia

Murk Jansen Type Metaphyseal Chondrodysplasia

Jansen Type Metaphyseal Chondrodysplasia

Jansen Disease

Jansen Metaphyseal Chondrodysplasia

Jansen Metaphyseal Dysostosis

Metaphyseal Chondrodysplasia Murk Jansen Type

Chondrodysplasia, Metaphyseal, Murk Jansen Type
Spondyloepimetaphyseal Dysplasia

Dysplasia, Spondyloepimetaphyseal
Spondyloepimetaphyseal Dysplasia, Krakow Type

SEMDK

Immunoosseous Dysplasia, Krakow Type
Achromatopsia 3

ACHM3

Pingelapese Blindness

Total Colorblindness With Myopia

Achromatopsia With Myopia

Achm1

Rmch1

Rod Monochromacy 1

Rod Monochromatism 1

Achm1, Formerly

Rod Monochromatism 1, Formerly

Rod Monochromacy 1, Formerly

Rmch1, Formerly

Achromatopsia-3

Achromatopsia, Type 3
Mesomelia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15776 HG-9-91-01 Inhibitor 99.77% Unkown
HY-101147 YKL-05-099 Inhibitor 99.76% Unkown
HY-120877 MRT199665 Inhibitor 99.74% Unkown
HY-120856 ARN-3236 Inhibitor 98.60% Unkown
HY-N1570 Pterosin B Inhibitor 99.92% Unkown
HY-157442 GLPG3312 Inhibitor 98.25% Unkown
HY-139253 MRIA9 Inhibitor 98.80% Unkown
HY-148061 DB1113 99.28% Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SIK3 VGNC VGNC:65144
Bos taurus SIK3 VGNC VGNC:34620
Rattus norvegicus SIK3 RGD RGD:1593938
Macaca mulatta SIK3 VGNC VGNC:77330
Mus musculus SIK3 MGD MGI:2446296
Canis familiaris SIK3 VGNC VGNC:46171
Others SIK3 NCBI