COTL1 - coactosin like F-actin binding protein 1 Gene

Homo sapiens

Also known as CLP

Gene ID: 23406 | Gene type: protein coding

About COTL1

Cytogenetic location: 16q24.1 Genomic coordinates (GRCh38): 16:84,565,596-84,618,078 (from NCBI)

This gene has 6 transcripts (splice variants), 197 orthologues and 4 paralogues. Broad expression in lymph node (RPKM 178.3), appendix (RPKM 165.6) and 20 other tissues.

Summary

This gene encodes one of the numerous actin-binding proteins which regulate the actin Cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed Enzyme in leukotriene biosynthesis. Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes. [provided by RefSeq, Jul 2008]

COTL1 Products(1)

mRNA	Protein	Name
NM_021149.5	NP_066972.1	coactosin-like protein

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables actin binding	IDA IDA: Inferred from direct assay	11583571	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	11297527	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11297527	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

COTL1 Protein Structure

Cofilin_ADF

0
100
142 a.a.

Protein Preferred Names

Protein Names

coactosin-like protein

coactosin-like 1

Related Diseases

Diseases

Alias

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Clivus Chordoma

Chordoma Of Clivus

Churg-Strauss Syndrome

Eosinophilic Granulomatosis With Polyangiitis	Allergic Granulomatous Angiitis
Churg-Strauss Vasculitis	Allergic Angiitis
Egpa	Granulomatous Allergic Angiitis
Allergic Granulomatosis Angiitis	Allergic Angiitis And Granulomatosis
Allergic Granulomatosis	Allergic Granulomatous And Angiitis
Css

Smith-Magenis Syndrome

SMS	Chromosome 17p11.2 Deletion Syndrome
17p11.2 Microdeletion Syndrome	17p11.2 Monosomy
Chromosome 17p Deletion Syndrome	Del(17)
P11.2	17p- Syndrome
Deletion 17p Syndrome	Partial Monosomy 17p

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03055	COTL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	COTL1	MGD	MGI:1919292
Rattus norvegicus	COTL1	RGD	RGD:1305498
Macaca mulatta	COTL1	VGNC	VGNC:71434
Canis familiaris	COTL1	VGNC	VGNC:39532
Bos taurus	COTL1	VGNC	VGNC:27626

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