MLYCD - malonyl-CoA decarboxylase Gene

Homo sapiens

Also known as MCD

Gene ID: 23417 | Gene type: protein coding

About MLYCD

Cytogenetic location: 16q23.3 Genomic coordinates (GRCh38): 16:83,899,115-83,927,031 (from NCBI)

This gene has 5 transcripts (splice variants), 198 orthologues and is associated with 3 phenotypes. Ubiquitous expression in heart (RPKM 24.2), liver (RPKM 11.1) and 24 other tissues.

Summary

The product of this gene catalyzes the breakdown of malonyl-CoA to acetyl-CoA and carbon dioxide. Malonyl-CoA is an intermediate in fatty acid biosynthesis, and also inhibits the transport of fatty acyl CoAs into mitochondria. Consequently, the encoded protein acts to increase the rate of fatty acid oxidation. It is found in mitochondria, peroxisomes, and the cytoplasm. Mutations in this gene result in malonyl-CoA decarboyxlase deficiency. [provided by RefSeq, Jul 2008]

MLYCD Products(1)

mRNA	Protein	Name
NM_012213.3	NP_036345.2	malonyl-CoA decarboxylase, mitochondrial

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	23791943	GOA
enables malonyl-CoA decarboxylase activity	IDA IDA: Inferred from direct assay	9869665	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in acetyl-CoA biosynthetic process	IDA IDA: Inferred from direct assay	9869665	GOA
involved in fatty acid biosynthetic process	IDA IDA: Inferred from direct assay	15003260	GOA
involved in malonyl-CoA catabolic process	IDA IDA: Inferred from direct assay	10417274	GOA
involved in positive regulation of fatty acid oxidation	IMP IMP: Inferred from mutant phenotype	18314420	GOA
involved in regulation of glucose metabolic process	IMP IMP: Inferred from mutant phenotype	18314420	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	10455107	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	10417274	GOA
located in peroxisome	IDA IDA: Inferred from direct assay	10417274	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MLYCD Protein Structure

MCD

0
100
200
300
400
493 a.a.

Protein Preferred Names

Protein Names

malonyl-CoA decarboxylase, mitochondrial

malonyl coenzyme A decarboxylase

MLYCD Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MLYCD	O95822	MLYCD	Homo sapiens	O95822	Solution Sedimentation	23791943
Intra	MLYCD	O95822	MLYCD	Homo sapiens	O95822	TEM	23791943
Intra	MLYCD	O95822	MLYCD	Homo sapiens	O95822	X-Ray Diffraction	23791943
Intra	MLYCD	O95822	MLYCD	Homo sapiens	O95822	GMS	23791943
Intra	MLYCD	O95822	NUMA1	Homo sapiens	Q14980	Crosslink	30021884

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Malonyl-Coa Decarboxylase Deficiency

Malonic Aciduria	Deficiency Of Malonyl-Coa Decarboxylase
Mcd Deficiency	Malonic Acidemia
Malonicaciduria	Malonyl-Coenzyme A Decarboxylase Deficiency
MLYCD DEFICIENCY

Combined Malonic And Methylmalonic Aciduria

CMAMMA	Combined Malonic And Methylmalonic Acidemia
Aciduria, Combined Malonic And Methylmalonic

Metabolic Acidosis

Alpha-Methylacyl-Coa Racemase Deficiency

Amacr Deficiency

AMACRD

Glutamate Formiminotransferase Deficiency

Formiminoglutamic Aciduria	Formiminotransferase Deficiency
FIGLU-URIA	Arakawa Syndrome 1
Formiminoglutamic Acidemia	Formiminotransferase Cyclodeaminase Deficiency
Formiminotransferase Deficiency Syndrome	Ftcd Deficiency
Formiminoglutamicaciduria	Figluria

Acyl-Coa Dehydrogenase, Very Long-Chain, Deficiency Of

Vlcad Deficiency	Very Long Chain Acyl-Coa Dehydrogenase Deficiency
Very Long-Chain Acyl-Coenzyme A Dehydrogenase Deficiency	Lcad Deficiency
Very Long-Chain Acyl-Coa Dehydrogenase Deficiency	Long Chain Acyl-Coa Dehydrogenase Deficiency
ACADVLD	Acadl Deficiency
Vlcadd	Long-Chain Acyl-Coa Dehydrogenase Deficiency
Acadvl	Acyl-Coa Dehydrogenase Very Long Chain Deficiency
Very Long-Chain Acyl Coenzyme A Dehydrogenase Deficiency	Vlcad-C
Vlcad-H	Acyl-Coa Dehydrogenase, Very Long Chain, Deficiency Of
Acyl-Coa Dehydrogenase Very Long-Chain Deficiency	Acyl-Coa Dehydrogenase Long-Chain Deficiency
Deficiency, Very Long Chain Acyl-Coa Dehydrogenase	Long Chain/Very Long Chain Acyl Coa Dehydrogenase Deficiency

Multiple Acyl-Coa Dehydrogenase Deficiency

MADD	Ethylmalonic-Adipicaciduria
Ema	Glutaric Acidemia Iia
Glutaric Acidemia Iib	Ga Ii
Glutaric Acidemia Iic	Glutaric Acidemia Type 2
Glutaric Acidemia Ii	Glutaric Aciduria Ii
Electron Transfer Flavoprotein Deficiency	Glutaric Aciduria Type 2
Mad Deficiency	Glutaric Acidemia Type Ii
Glutaric Aciduria 2	Etfa Deficiency
Etfb Deficiency	Etfdh Deficiency
Multiple Acyl Coenzyme A Dehydrogenase Deficiency	Ga2
Electron Transfer Flavoprotein Ubiquinone Oxidoreductase Deficiency	Electron Transfer Flavoprotein Dehydrogenase Deficiency
Ga 2	Glutaric Acidemia 2
Glutaric Acidemia, Type 2	Glutaric Aciduria, Type 2
Mad	Multiple Fad Dehydrogenase Deficiency
Ethylmalonic Adipic Aciduria	Glutaricaciduria Ii
Glutaric Aciduria 2a	GA2A
Gaiia	Glutaricaciduria Iia
Glutaric Aciduria 2b	GA2B
Gaiib	Glutaricaciduria Iib
Glutaric Aciduria 2c	GA2C
Gaiic	Glutaricaciduria Iic
Glutaricaciduria, Type Iia	Glutaric Acidemia Type 2a
Glutaric Acidemia Type 2c	Glutaric Aciduria Iia
Glutaric Aciduria Iib	Glutaric Aciduria Iic

Constipation

Peroxisome Biogenesis Disorder 1b

Peroxisome Biogenesis Disorder	Infantile Refsum Disease
Infantile Phytanic Acid Storage Disease	PBD1B
Refsum Disease, Infantile	Adrenoleukodystrophy, Autosomal Neonatal
Ird	Mild Pbd-Zsd
Mild Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder	Pbd-Zsd
Peroxisome Biogenesis Disorder Spectrum	Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder
Autosomal Neonatal Adrenoleukodystrophy	Refsum Disease Infantile
Peroxisome Biogenesis Disorders	Peroxisome Biogenesis Disorder, Type 1b

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08506	MLYCD Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MLYCD	RGD	RGD:620234
Mus musculus	MLYCD	MGD	MGI:1928485
Felis catus	MLYCD	VGNC	VGNC:97511
Bos taurus	MLYCD	VGNC	VGNC:97287
Canis familiaris	MLYCD	VGNC	VGNC:57369
Others	MLYCD	NCBI

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