NUMA1 - nuclear mitotic apparatus protein 1 Gene

Homo sapiens

Also known as NUMA; NMP-22

Gene ID: 4926 | Gene type: protein coding

About NUMA1

Cytogenetic location: 11q13.4 Genomic coordinates (GRCh38): 11:72,002,864-72,080,542 (from NCBI)

This gene has 33 transcripts (splice variants), 148 orthologues, 3 paralogues and is associated with 88 phenotypes. Ubiquitous expression in prostate (RPKM 51.4), ovary (RPKM 49.9) and 25 other tissues.

Summary

This gene encodes a large protein that forms a structural component of the nuclear matrix. The encoded protein interacts with microtubules and plays a role in the formation and organization of the mitotic spindle during cell division. Chromosomal translocation of this gene with the RARA (retinoic acid receptor, alpha) gene on chromosome 17 have been detected in patients with acute promyelocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

NUMA1 Products(2)

mRNA	Protein	Name
NM_001286561.2	NP_001273490.1	nuclear mitotic apparatus protein 1 isoform 2
NM_006185.4	NP_006176.2	nuclear mitotic apparatus protein 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables disordered domain specific binding	IMP IMP: Inferred from mutant phenotype	20109190	GOA
enables dynein complex binding	IDA IDA: Inferred from direct assay	10811826	GOA
enables microtubule binding	IDA IDA: Inferred from direct assay	11956313	GOA
enables microtubule minus-end binding	IDA IDA: Inferred from direct assay	26765568	GOA
enables microtubule plus-end binding	IDA IDA: Inferred from direct assay	26765568	GOA
enables phosphatidylinositol binding	IDA IDA: Inferred from direct assay	24371089	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11590136	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	22074847	GOA
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	11590136	GOA
enables tubulin binding	IDA IDA: Inferred from direct assay	11956313	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in anastral spindle assembly	IMP IMP: Inferred from mutant phenotype	25657325	GOA
involved in astral microtubule organization	IDA IDA: Inferred from direct assay	12445386	GOA
involved in astral microtubule organization	IMP IMP: Inferred from mutant phenotype	12445386	GOA
involved in establishment of mitotic spindle orientation	IDA IDA: Inferred from direct assay	21816348	GOA
involved in establishment of mitotic spindle orientation	IMP IMP: Inferred from mutant phenotype	24996901	GOA
involved in microtubule bundle formation	IMP IMP: Inferred from mutant phenotype	12445386	GOA
involved in positive regulation of chromosome segregation	IMP IMP: Inferred from mutant phenotype	24371089	GOA
involved in positive regulation of chromosome separation	IMP IMP: Inferred from mutant phenotype	23921553	GOA
involved in positive regulation of intracellular transport	IMP IMP: Inferred from mutant phenotype	27462074	GOA
involved in positive regulation of microtubule polymerization	IMP IMP: Inferred from mutant phenotype	12445386	GOA
involved in positive regulation of mitotic spindle elongation	IMP IMP: Inferred from mutant phenotype	23921553	GOA
involved in positive regulation of protein localization to cell cortex	IMP IMP: Inferred from mutant phenotype	22327364	GOA
involved in positive regulation of protein localization to spindle pole body	IDA IDA: Inferred from direct assay	16076287	GOA
involved in positive regulation of spindle assembly	IMP IMP: Inferred from mutant phenotype	27462074	GOA
involved in regulation of metaphase plate congression	IMP IMP: Inferred from mutant phenotype	27462074	GOA
involved in regulation of mitotic spindle organization	IDA IDA: Inferred from direct assay	26195665	GOA
involved in regulation of mitotic spindle organization	IMP IMP: Inferred from mutant phenotype	11956313	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell cortex	IDA IDA: Inferred from direct assay	22327364	GOA
located in cell cortex region	IDA IDA: Inferred from direct assay	21816348	GOA
located in centrosome	IDA IDA: Inferred from direct assay	7962183	GOA
located in cortical microtubule	IDA IDA: Inferred from direct assay	26765568	GOA
located in cytoplasmic microtubule bundle	IDA IDA: Inferred from direct assay	12445386	GOA
located in cytosol	IDA IDA: Inferred from direct assay	7962183	GOA
located in microtubule bundle	IDA IDA: Inferred from direct assay	11956313	GOA
located in microtubule minus-end	IDA IDA: Inferred from direct assay	26765568	GOA
located in microtubule plus-end	IDA IDA: Inferred from direct assay	26765568	GOA
located in mitotic spindle	IDA IDA: Inferred from direct assay	10811826	GOA
located in mitotic spindle astral microtubule	IDA IDA: Inferred from direct assay	1541636	GOA
located in mitotic spindle midzone	IDA IDA: Inferred from direct assay	10811826	GOA
located in mitotic spindle pole	IDA IDA: Inferred from direct assay	1541636	GOA
located in mitotic spindle pole	IMP IMP: Inferred from mutant phenotype	17172455	GOA
located in nuclear matrix	IDA IDA: Inferred from direct assay	7962183	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	10811826	GOA
located in nucleus	IDA IDA: Inferred from direct assay	1541636	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	24371089	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	22074847	GOA
part of protein-containing complex	IMP IMP: Inferred from mutant phenotype	20109190	GOA
located in spindle microtubule	IDA IDA: Inferred from direct assay	1541636	GOA
located in spindle pole	IDA IDA: Inferred from direct assay	14718566	GOA
located in spindle pole centrosome	IDA IDA: Inferred from direct assay	10811826	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

nuclear mitotic apparatus protein 1

SP-H antigen

NUMA1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NUMA1	Q14980	FLJ13057	Homo sapiens	Q53SE7	Y2H Array	25416956
Intra	NUMA1	Q14980	KRT4	Homo sapiens	P19013	Crosslink	30021884
Intra	NUMA1	Q14980	GNAI1	Homo sapiens	P63096	Pull Down	15537540
Intra	NUMA1	Q14980	GPSM2	Homo sapiens	P81274	Pull Down	15537540
Intra	NUMA1	Q14980	GPSM2	Homo sapiens	P81274	IF	15537540
Intra	NUMA1	Q14980	RAE1	Homo sapiens	P78406	Anti Tag CoIP	35271311
Intra	NUMA1	Q14980	TERF2IP	Homo sapiens	Q9NYB0	Pull Down	21044950

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic	Acute Myeloblastic Leukemia Type 3
Aml M3	APL
Leukemia, Acute Promyelocytic, Somatic	Aml With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Apml
Acute Myeloblastic Leukemia 3	Acute Myeloid Leukemia With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Acute Myeloblastic Leukaemia Type 3
Acute Myeloid Leukaemia M3	Acute Myeloid Leukemia M3
Acute Promyelocytic Leukaemia	M3 Anll
Myeloid Leukemia, Acute, M3	Leukemia Promyelocytic Acute
Leukemia, Promyelocytic, Acute	Leukemia, Acute, Promyelocytic

Bladder Calculus

Urinary Bladder Calculi	Urinary Bladder Stone
Bladder Calculi	Bladder Stone
Urinary Bladder Calculus	Vesical Calculi
Vesical Calculus	Vesicolithiasis
Cystolithiasis	Cystic Calculi
Cystic Calculus

Lower Urinary Tract Calculus

Calculus Of Lower Urinary Tract

Ureter Adenocarcinoma

Adenocarcinoma Of Ureter

Ureteral Adenocarcinoma

Non-Invasive Bladder Papillary Urothelial Neoplasm

Bladder Papillary Neoplasm Of Low Malignant Potential	Bladder Punlmp
Papillary Urothelial Neoplasm Of Low Malignant Potential	Papillary Transitional Cell Neoplasm Of Low Malignant Potential

Cherubism

CRBM	Familial Benign Giant-Cell Tumor Of The Jaw
Familial Fibrous Dysplasia Of Jaw	Familial Multilocular Cystic Disease Of The Jaws

Ureter, Cancer Of

Ureter Carcinoma	Ureter Cancer
Ureteral Neoplasms	Malignant Neoplasm Of Ureter
Malignant Tumour Of Ureter	Malignant Ureteral Tumor
Ureteral Carcinoma	Ureteral Neoplasm

Bladder Cancer

Urinary Bladder Cancer	Bladder Carcinoma
Urinary Bladder Carcinoma	Bladder Neoplasm
Bladder Tumor	Cancer, Bladder
Malignant Neoplasm Of Urinary Bladder	Carcinoma Of Bladder
Bladder Cancer, Somatic	Tumor Of The Bladder
Carcinoma Of Urinary Bladder	Bladder Carcinoma Urinary
Cancer Of The Urinary Bladder	Cancer, Urinary Bladder
Malignant Bladder Neoplasm	Malignant Bladder Tumor
Neoplasm Of The Bladder	Neoplasm Of The Urinary Bladder
Tumor Of The Urinary Bladder	Urinary Bladder Neoplasm
BLC	Urothelial Carcinoma Of The Bladder
Bladder Tumors	Urinary Bladder Neoplasms
Bladder Cancer Nos	Vesical Cancer Nos
Malignant Neoplasm Of Bladder, Part Unspecified	Malignant Tumour Of Urinary Bladder
Primary Malignant Neoplasm Of Bladder

Bladder Papillary Transitional Cell Neoplasm

Urinary Bladder Papillary Urothelial Neoplasm

Bladder Papillary Urothelial Neoplasm

Urinary Tract Papillary Transitional Cell Benign Neoplasm

Inverted Papilloma Of Urinary Tract	Papillary Transitional Cell Neoplasm Of The Urinary Tract
Urinary Tract Inverted Papilloma	Inverted Urothelial Papilloma

Bladder Carcinoma In Situ

Carcinoma In Situ Of Bladder	Bladder Ca In Situ
Flat Cis Of The Urinary Bladder	Carcinoma In Situ Of Urinary Bladder

Transitional Cell Carcinoma

Transitional Cell Neoplasm	Carcinoma, Transitional Cell
Transitional Carcinoma	Transitional Cell Tumor
Urothelial Cell Carcinoma	Carcinoma Transitional Cell
Transitional Cell Carcinoma Of Bladder

Pyuria

Pus Cells In Urine

Invasive Bladder Transitional Cell Carcinoma

Invasive Bladder Urothelial Carcinoma

Infiltrating Bladder Urothelial Carcinoma

Chronic Cystitis

Primary Autosomal Recessive Microcephaly

Autosomal Recessive Primary Microcephaly	Mcph
True Microcephaly	Microcephalia Vera
Microcephaly Vera	Microcephaly Primary Hereditary
Microcephaly, Primary, Autosomal Recessive	Primary Microcephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09680	NUMA1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	NUMA1	VGNC	VGNC:32348
Rattus norvegicus	NUMA1	RGD	RGD:1308777
Macaca mulatta	NUMA1	VGNC	VGNC:75556
Felis catus	NUMA1	VGNC	VGNC:68594
Canis familiaris	NUMA1	VGNC	VGNC:44042
Mus musculus	NUMA1	MGD	MGI:2443665

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