2. Gene
  3. SF3B3 - splicing factor 3b subunit 3 Gene

SF3B3 - splicing factor 3b subunit 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as RSE1; SAP130; SF3b130; STAF130

Gene ID: 23450 | Gene type: protein coding

About SF3B3

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:70,523,816-70,577,668 (from NCBI)

This gene has 15 transcripts (splice variants), 209 orthologues and 2 paralogues. Ubiquitous expression in ovary (RPKM 13.7), lymph node (RPKM 13.6) and 25 other tissues.

Summary

This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (Histone Acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair. [provided by RefSeq, Jul 2008]

SF3B3 Products(1)

mRNA Protein Name
NM_012426.5 NP_036558.3 splicing factor 3B subunit 3
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
17332742 GOA
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
11564863 GOA
Biological Process GO Annotation Evidence Reference Source
involved in mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
27720643 GOA
involved in negative regulation of protein catabolic process IDA
IDA: Inferred from direct assay
23951410 GOA
Cellular Component GO Annotation Evidence Reference Source
part of U12-type spliceosomal complex IDA
IDA: Inferred from direct assay
15146077 GOA
part of U2-type precatalytic spliceosome IDA
IDA: Inferred from direct assay
28781166 GOA
part of U2-type spliceosomal complex IDA
IDA: Inferred from direct assay
32494006 GOA
part of U2-type spliceosomal complex IPI
IPI: Inferred from physical interaction
27720643 GOA
part of catalytic step 2 spliceosome IDA
IDA: Inferred from direct assay
11991638 GOA
located in nucleus IDA
IDA: Inferred from direct assay
27720643 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SF3B3 Protein Structure

MMS1_N

MMS1_N: Mono-functional DNA-alkylating methyl methanesulfonate N-term (76 - 592)

CPSF_A

CPSF_A: CPSF A subunit region (863 - 1183)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1217 a.a.
Protein Preferred Names Protein Names

splicing factor 3B subunit 3

SAP 130

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12762 SF3B3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SF3B3 VGNC VGNC:77181
Bos taurus SF3B3 VGNC VGNC:34511
Felis catus SF3B3 VGNC VGNC:65057
Rattus norvegicus SF3B3 RGD RGD:1311636
Mus musculus SF3B3 MGD MGI:1289341
Canis familiaris SF3B3 VGNC VGNC:46071
Others SF3B3 NCBI