SF3B3 - splicing factor 3b subunit 3 Gene

Homo sapiens

Also known as RSE1; SAP130; SF3b130; STAF130

Gene ID: 23450 | Gene type: protein coding

About SF3B3

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:70,523,816-70,577,668 (from NCBI)

This gene has 15 transcripts (splice variants), 209 orthologues and 2 paralogues. Ubiquitous expression in ovary (RPKM 13.7), lymph node (RPKM 13.6) and 25 other tissues.

Summary

This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (Histone Acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair. [provided by RefSeq, Jul 2008]

SF3B3 Products(1)

mRNA	Protein	Name
NM_012426.5	NP_036558.3	splicing factor 3B subunit 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17332742	GOA
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	11564863	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	27720643	GOA
involved in negative regulation of protein catabolic process	IDA IDA: Inferred from direct assay	23951410	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of U12-type spliceosomal complex	IDA IDA: Inferred from direct assay	15146077	GOA
part of U2-type precatalytic spliceosome	IDA IDA: Inferred from direct assay	28781166	GOA
part of U2-type spliceosomal complex	IDA IDA: Inferred from direct assay	32494006	GOA
part of U2-type spliceosomal complex	IPI IPI: Inferred from physical interaction	27720643	GOA
part of catalytic step 2 spliceosome	IDA IDA: Inferred from direct assay	11991638	GOA
located in nucleus	IDA IDA: Inferred from direct assay	27720643	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SF3B3 Protein Structure

MMS1_N

CPSF_A

0
200
400
600
800
1000
1217 a.a.

Protein Preferred Names

Protein Names

splicing factor 3B subunit 3

SAP 130

SF3B3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SF3B3	Q15393	SF3A3	Homo sapiens	Q12874	Anti Tag CoIP	35271311
Intra	SF3B3	Q15393	SF3A3	Homo sapiens	Q12874	Crosslink	30021884
Intra	SF3B3	Q15393	SF3A2	Homo sapiens	Q15428	Affinity Chrom	17332742

Cross: Cross-species interaction Intra: Intraspecies interaction

SF3B3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81426	SF3B3 Antibody (YA1171)	IHC-P	Human

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12762	SF3B3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SF3B3	VGNC	VGNC:77181
Bos taurus	SF3B3	VGNC	VGNC:34511
Felis catus	SF3B3	VGNC	VGNC:65057
Rattus norvegicus	SF3B3	RGD	RGD:1311636
Mus musculus	SF3B3	MGD	MGI:1289341
Canis familiaris	SF3B3	VGNC	VGNC:46071
Others	SF3B3	NCBI

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