SF3B3 - splicing factor 3b subunit 3 Gene

Homo sapiens

Also known as RSE1; SAP130; SF3b130; STAF130

Gene ID: 23450 | Gene type: protein coding

About SF3B3

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:70,523,816-70,577,668 (from NCBI)

This gene has 15 transcripts (splice variants), 209 orthologues and 2 paralogues. Ubiquitous expression in ovary (RPKM 13.7), lymph node (RPKM 13.6) and 25 other tissues.

Summary

This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (Histone Acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair. [provided by RefSeq, Jul 2008]

SF3B3 Products(1)

mRNA	Protein	Name
NM_012426.5	NP_036558.3	splicing factor 3B subunit 3

SF3B3 Protein Structure

MMS1_N

CPSF_A

0
200
400
600
800
1000
1217 a.a.

Protein Preferred Names

Protein Names

splicing factor 3B subunit 3

SAP 130

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12762	SF3B3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SF3B3	VGNC	VGNC:77181
Bos taurus	SF3B3	VGNC	VGNC:34511
Felis catus	SF3B3	VGNC	VGNC:65057
Rattus norvegicus	SF3B3	RGD	RGD:1311636
Mus musculus	SF3B3	MGD	MGI:1289341
Canis familiaris	SF3B3	VGNC	VGNC:46071
Others	SF3B3	NCBI

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