SEC11A - SEC11 homolog A, signal peptidase complex subunit Gene

Homo sapiens

Also known as SPC18; SPCS4A; SEC11L1; sid2895; 1810012E07Rik

Gene ID: 23478 | Gene type: protein coding

About SEC11A

Cytogenetic location: 15q25.2-q25.3 Genomic coordinates (GRCh38): 15:84,669,544-84,716,139 (from NCBI)

This gene has 10 transcripts (splice variants), 220 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 67.9), fat (RPKM 55.2) and 25 other tissues.

Summary

This gene encodes a member of the peptidase S26B family. The encoded protein is an 18kDa subunit of the signal peptidase complex and has been linked to cell migration and invasion, gastric Cancer and lymph node metastasis. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 8. [provided by RefSeq, Dec 2012]

SEC11A Products(6)

mRNA	Protein	Name
NM_001271918.2	NP_001258847.1	signal peptidase complex catalytic subunit SEC11A isoform 5
NM_001271919.2	NP_001258848.1	signal peptidase complex catalytic subunit SEC11A isoform 6
NM_001271920.2	NP_001258849.1	signal peptidase complex catalytic subunit SEC11A isoform 4
NM_001271921.2	NP_001258850.1	signal peptidase complex catalytic subunit SEC11A isoform 1
NM_001271922.2	NP_001258851.1	signal peptidase complex catalytic subunit SEC11A isoform 3
NM_014300.4	NP_055115.1	signal peptidase complex catalytic subunit SEC11A isoform 2

SEC11A Protein Structure

Peptidase_S24

0
100
179 a.a.

Protein Preferred Names

Protein Names

signal peptidase complex catalytic subunit SEC11A

SEC11-like protein 1

Related Diseases

Diseases

Alias

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12603	SEC11A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SEC11A	VGNC	VGNC:80851
Macaca mulatta	SEC11A	VGNC	VGNC:99235
Bos taurus	SEC11A	VGNC	VGNC:53951
Mus musculus	SEC11A	MGD	MGI:1929464
Rattus norvegicus	SEC11A	RGD	RGD:69360
Canis familiaris	SEC11A	VGNC	VGNC:53239

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