SPCS3 - signal peptidase complex subunit 3 Gene

Homo sapiens

Also known as SPC3; SPC22; SPC23; PRO3567; YLR066W; SPC22/23

Gene ID: 60559 | Gene type: protein coding

About SPCS3

Cytogenetic location: 4q34.2 Genomic coordinates (GRCh38): 4:176,319,966-176,332,245 (from NCBI)

This gene has 4 transcripts (splice variants) and 215 orthologues. Ubiquitous expression in thyroid (RPKM 45.3), appendix (RPKM 34.4) and 25 other tissues.

Summary

Predicted to enable peptidase activity. Involved in proteolysis and viral protein processing. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

SPCS3 Products(1)

mRNA	Protein	Name
NM_021928.4	NP_068747.1	signal peptidase complex subunit 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25959826	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in proteolysis	IDA IDA: Inferred from direct assay	27499293	GOA
involved in signal peptide processing	IDA IDA: Inferred from direct assay	34388369	GOA
involved in viral protein processing	IMP IMP: Inferred from mutant phenotype	27383988	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	34388369	GOA
part of signal peptidase complex	IPI IPI: Inferred from physical interaction	34388369	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SPCS3 Protein Structure

SPC22

0
100
180 a.a.

Protein Preferred Names

Protein Names

signal peptidase complex subunit 3

SPase 22 kDa subunit

SPCS3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SPCS3	P61009	SEC11A	Homo sapiens	P67812	Anti Tag CoIP	33961781
Intra	SPCS3	P61009	SEC11C	Homo sapiens	Q9BY50	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Omsk Hemorrhagic Fever

Ohf	Hemorrhagic Fever, Omsk
Ohf - [Omsk Haemorrhagic Fever]	Spring-Fall Haemorrhagic Fever

Tick Infestation

Tick Infestations

Mixed Ductal-Endocrine Carcinoma

Yellow Fever

Urban Yellow Fever	Jungle Yellow Fever
Sylvatic Yellow Fever	Yf
Yellow Fever, Sylvan	Bronze John
Yellow Jack	Yf- [Yellow Fever]
Febris Flava

Parasitic Ectoparasitic Infectious Disease

Ectoparasitic Infestations

Ectoparasitism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13651	SPCS3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SPCS3	VGNC	VGNC:82299
Felis catus	SPCS3	VGNC	VGNC:107468
Rattus norvegicus	SPCS3	RGD	RGD:1588184
Macaca mulatta	SPCS3	VGNC	VGNC:77995
Mus musculus	SPCS3	MGD	MGI:1923937
Bos taurus	SPCS3	VGNC	VGNC:58352

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