ZNF281 - zinc finger protein 281 Gene

Homo sapiens

Also known as GZP1; ZBP99; ZBP-99; ZNP-99

Gene ID: 23528 | Gene type: protein coding

About ZNF281

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:200,404,951-200,410,036 (from NCBI)

This gene has 3 transcripts (splice variants), 244 orthologues and 36 paralogues. Ubiquitous expression in bone marrow (RPKM 10.1), appendix (RPKM 5.7) and 25 other tissues.

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of gene expression; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription, DNA-templated. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ZNF281 Products(3)

mRNA	Protein	Name
NM_001281293.2	NP_001268222.1	zinc finger protein 281 isoform 1
NM_001281294.2	NP_001268223.1	zinc finger protein 281 isoform 2
NM_012482.5	NP_036614.1	zinc finger protein 281 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	10448078	GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	10448078	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	10448078	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17314511	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	10405178	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	10448078	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12771217	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	10448078	GOA
involved in negative regulation of gene expression	IDA IDA: Inferred from direct assay	12771217	GOA
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	10448078	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10448078	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	10405178	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	10448078	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZNF281 Protein Structure

zf-H2C2_2

0
200
400
600
800
895 a.a.

Protein Preferred Names

Protein Names

zinc finger protein 281

GC-box-binding zinc finger protein 1

ZNF281 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ZNF281	Q9Y2X9	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
Intra	ZNF281	Q9Y2X9	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
Intra	ZNF281	Q9Y2X9	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053
Intra	ZNF281	Q9Y2X9	OPTN	Homo sapiens	Q96CV9	Validated Y2H	32814053
Intra	ZNF281	Q9Y2X9	OPTN	Homo sapiens	Q96CV9	Y2H Pooling	32814053
Intra	ZNF281	Q9Y2X9	OPTN	Homo sapiens	Q96CV9	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16120	ZNF281 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ZNF281	RGD	RGD:1305139
Mus musculus	ZNF281	MGD	MGI:3029290
Macaca mulatta	ZNF281	VGNC	VGNC:100192

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